Forskningsgrupper i Neurocentret

Neurocentrets forskningsgrupper arbejder med forskning og udvikling af behandling og pleje af hjerne- og nervesygdomme.

Neurointensiv Forskningsgruppe

Our research group, which is a collaboration across specialities and professions, focuses on the mechanisms and manifestations of severe acute CNS disease. We use multimodal neuromonitoring, both to improve treatment and to understand the pathophysiology of ischaemic and haemorrhagic stroke, traumatic brain injury and spinal cord injury.

Dansk Center for Søvnsygdomme

​Our research group focuses on understanding and defining normal and pathological sleep-wake processes. A major research area includes developing new diagnostic and treatment procedures including advanced signal analysis on biomedical signals, molecular methods in sleep research. We apply these results into clinical research to refine diagnosis and treatment. The research includes big data analysis for understanding disease consequences, comorbidities and effect of management.

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Nationalt Videnscenter for Demens

​Danish Dementia Research Centre research programmes are based mainly on clinical cohorts of patients from our memory clinics, from national or international projects, or from the Danish national registries and cover a wide spectrum of clinical

and translational research in neurodegenerative disorders. The health service and intervention research programmes with direct relevance to improving the quality of dementia care in Denmark as an integral part of our National Info & Education Centre for Dementia are funded in part by the Danish Ministry of Health.

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Dansk Hovedpinecenter

​​The Danish Headache Center has an extensive research programme within mechanisms and treatment of migraine, cluster headache, tension-type headache, and trigeminal neuralgia.

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Dansk Multipel Sklerose Center

​The MS Research Unit's research activities include: 

  • clinical research in therapeutic trials, symptomatic therapy and rehabilitation; 
  •  genetics in MS; 
  • pathogenesis of MS including research in immunological changes in MS; 
  • pathology in MS

The MS Research Unit has an extensive collaboration with other institutions in Denmark and other European countries. The MS Research Unit is supported by both national and international grants.

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​Our research group focuses on multimodal epilepsy surgery evaluation which includes implementation of advanced MR techniques (7T) and development of a national epilepsy surgery database. We are studying electric nerve stimulation (transcutaneous VNS), sudden unexpected death in epilepsy, osteoporosis, and teratogenic and pharmacogenetic aspects of antiepileptic drugs.​

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Neuroanæstesiologisk Forskningsgruppe

​We study cerebral physiology and pathophysiology as well as the effect of anaesthetics, vasoactive and other medications in patients undergoing neurosurgery for brain tumours, magnetic resonance imaging, and endovascular therapy.

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Neurobiologisk Forskningsenhed

​We make use of in vivo molecular, structural and functional brain imaging to uncover disease mechanisms and risk correlates as well as to determine drug effects. We also make use of animal and cell models as well as human brain tissue to investigate drug effects and diagnostic value in the clinic. 

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Neuromuskulær Forskningsenhed

Our research group focuses on developing mouse models of new muscle diseases, defining the pathophysiology of numerous muscle diseases, participating in industry- and investigator-driven clinical trials, designing rehabilitation programs for people with neuromuscular disorders, and using advanced MR techniques to describe pathophysiology and develop sensitive outcome measures for therapeutic trials.

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Forskning i kroniske smerter

We use human-experimental models to investigate the pathophysiology of pain, and conduct research on the effect of novel strategies for pain treatment. We study the use of opioids based on national registries, the involvement of patients and their significant others in the treatment trajectory, as well as the consequences for adult children of chronic nonmalignant pain parents.

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Neurokirurgisk Forskningsenhed (PERNS)

Neurosurgery is by default personalized. Management and procedures are tailored according to scientific knowledge and clinical experience to provide meaningful care for all neurosurgical patients and "number needed to treat" (NNT) is kept close to one. For this end, causal explanations are sought in translational projects to explain neurosurgical pathophysiology and prospective clinical studies are used to corroborate clinical efficacy in well characterized groups of patients.

 The center includes the following collaborative groups:

Copenhagen CSF study group: 
A particular focus of the Copenhagen CSF Study Group is the translational integration between experimental and clinical research, exploiting inspiration from clinical problems to formulate research questions, and subsequently applying results from this research to solve notoriously difficult issues about clinical hydrocephalus management. Unique pressure recordings and studies of glymphatic flow in man establish a novel view of CSF physiology and hydrocephalus. 

Copenhagen neurosurgical brain tumour group: 
Research is collaborative with research groups at the Danish Cancer Society,research groups at Rigshospitalet and University of Copenhagen, Cambridge university and Karolinska Intitutet. Focus is on DNA damage, targeted treatment, new treatments, translational research and imaging studies. Brain tumour biology is studied in primary specimens and cultures to determine individual tumour characteristics for therapy, tumour biology and tumour crosstalk. Surgical management and relationship of surgery, epilepsy, edema and inflammation to neuropsychological parameters is analyzed. Advanced PET, SPECT and fMRI imaging is employed. Biomarkers are sought to develop an algorithm for individually tailored chemo- and radiotherapy based on tumour biomarkers and treatment responses in experimental systems for gliomas and meningiomas.

Inflammation group: 
Analysis and management of individual patterns and biomarkers of inflammatory responses affect rupture of aneurysms, delayed neurological deterioration in SAH-patients and pathophysiology of brain-trauma; relationship between activation of inflammatory cells, cell-death, mitochondrial function, spreading depression, ischemia and oxidative mechanisms.

Cognition and emotional neurosurgical research:
Research on anxiety, depression and cognitive deterioration after elective surgery and subarachnoid hemorrhages.  Studies on coping, pain and quality of life in relation to time after surgery, expectations, support, neurological symptoms, anxiety, depression and cognitive deterioration after elective surgery and subarachnoid hemorrhage.

Vascular research group:
Subarachnoid hemorrhage causes delayed ischemic deficit, csf circulation disturbances and neuropsychological morbidity in survivors.  The mechanisms of delayed deterioration, pathophysiology and depressive/anxious states are studied with special reference to biomarkers, spreading depression, glymphatic flow and neuro-inflammation.

Epidemiology group:
Epidemiological studies to clarify pathology and outcomes of neurosurgical diseases.

Forskningsenheden RUBRIC (hjerneskader)

Research Unit on Brain Injury Copenhagen (RUBRIC) carries out clinical research within the following three strategic areas:

  • Pathophysiological mechanism of severe brain injury
  • Development of evidence for various rehabilitation methods and technologies
  • Systematic data collection and analysis of the perspective of patients and relatives on the rehabilitation after severe brain injury
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Forskning i Afdeling for Rygmarvsskader

​Clinical and epidemiological research related to the challenges individuals with spinal cord lesions face has been the priority, including studies on respiratory and cardiovascular function, blasser and bowel management, sexual finction and fertility, pain, spasticity, osteoporosis, sleep disturbances, etc. Functional electrical stimulation and other treatment modalities are used. The clinic participates in standardization of data collection internationally.

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Enhed for Klinisk Apopleksiforskning

​Our research includes epidemiology, clinical and translational research and participation in industry- and investigator-driven national and international clinical trials. In the acute phase we focus on biomarkers, stroke pathophysiology and classification, sleep disturbances and low frequency oscillations. In the early rehabilitation phase focus is on effects of naturalistic lighting, circadian rythm and post-stroke depression. 

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