Publikationer
Igangværende ph.d.-projekter
- “Immune Responses to COVID-19 Vaccines in Immunocompromised Patients– Line Dam Heftdal, Læge, PhD-studerende
Publikationer
Münter R, Sørensen E, Hasselbalch RB, Christensen E, Nielsen SD, Garred P, Ostrowski SR, Bundgaard H, Iversen KK, Andresen TL, Larsen JB. Investigating Generation of Antibodies against the Lipid Nanoparticle Vector Following COVID-19 Vaccination with an mRNA Vaccine. Mol Pharm. 2023 Mar 23. doi:
10.1021/acs.molpharmaceut.2c01036. Epub ahead of print.
Madsen JR, Holm BE, Pérez-Alós L, Bayarri-Olmos R, Rosbjerg A, Fogh K, Pries-Heje MM, Møller DL, Hansen CB, Heftdal LD, Hasselbalch RB, Hamm SR, Frikke-Schmidt R, Hilsted L, Nielsen SD, Iversen KK, Bundgaard H, Garred P. Short-Lived Antibody-Mediated Saliva Immunity against SARS-CoV-2 after Vaccination. Microbiol Spectr. 2023 Mar 6:e0494722. doi: 10.1128/spectrum.04947-22. Epub ahead of print.
Rezahosseini O, Hamm SR, Heftdal LD, Pérez-Alós L, Møller DL, Perch M, Madsen JR, Hald A, Hansen CB, Armenteros JJA, Pries-Heje MM, Hasselbalch RB, Fogh K, Frikke-Schmidt R, Hilsted LM, Sørensen E, Ostrowski SR, Harboe ZB, Iversen K, Bundgaard H, Sørensen SS, Rasmussen A, Garred P, Nielsen SD. Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls: Kinetics, associated factors, and role of SARS-CoV-2 infection. Front Immunol. 2023 Jan 13;13:1075423. doi: 10.3389/fimmu.2022.1075423.
Kvist-Hansen A, Pérez-Alós L, Al-Sofi RF, Heftdal LD, Hamm SR, Møller DL, Pries-Heje MM, Fogh K, Hansen CB, Hasselbalch RB, Madsen JR, Armenteros JJA, Frikke-Schmidt R, Hilsted L, Sørensen E, Ostrowski SR, Bundgaard H, Nielsen SD, Iversen K, Zachariae C, Garred P, Skov L. Waning humoral and cellular immunity after COVID-19 vaccination in patients with psoriasis treated with methotrexate and biologics: a cohort study. Br J Dermatol. 2023 Jan 27:ljad023. doi: 10.1093/bjd/ljad023. Epub ahead of print.
Harboe ZB, Hamm SR, Pérez-Alós L, Sivapalan P, Priemé H, Wilcke T, Kjeldgaard P, Shaker S, Svorre Jordan A, Møller DL, Heftdal LD, Madsen JR, Bayarri-Olmos R, Hansen CB, Pries-Heje MM, Hasselbalch RB, Fogh K, Armenteros JJA, Hilsted L, Sørensen E, Lindegaard B, Browatzki A, Biering-Sørensen T, Frikke-Schmidt R, Ostrowski SR, Iversen KK, Bundgaard H, Nielsen SD, Garred P, Jensen JS. Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases. BMJ Open Respir Res. 2022 Jul;9(1):e001268. doi: 10.1136/bmjresp-2022-001268.
Heftdal LD, Knudsen AD, Hamm SR, Hansen CB, Møller DL, Pries-Heje M, Fogh K, Hasselbalch RB, Jarlhelt I, Pérez-Alós L, Hilsted LM, Ostrowski SR, Gerstoft J, Grønbaek K, Bundgaard H, Iversen K, Garred P, Nielsen SD. Humoral response to two doses of BNT162b2 vaccination in people with HIV. J Intern Med. 2022 Apr;291(4):513-518. doi: 10.1111/joim.13419. Epub 2021 Dec 16.
Pérez-Alós L, Armenteros JJA, Madsen JR, Hansen CB, Jarlhelt I, Hamm SR, Heftdal LD, Pries-Heje MM, Møller DL, Fogh K, Hasselbalch RB, Rosbjerg A, Brunak S, Sørensen E, Larsen MAH, Ostrowski SR, Frikke-Schmidt R, Bayarri-Olmos R, Hilsted LM, Iversen KK, Bundgaard H, Nielsen SD, Garred P. Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors. Nat Commun. 2022 Mar 28;13(1):1614. doi: 10.1038/s41467-022-29225-4.
Hamm SR, Møller DL, Pérez-Alós L, Hansen CB, Pries-Heje MM, Heftdal LD, Hasselbalch RB, Fogh K, Madsen JR, Almagro Armenteros JJ, Knudsen AD, Poulsen JR, Frikke-Schmidt R, Hilsted LM, Sørensen E, Ostrowski SR, Harboe ZB, Perch M, Sørensen SS, Rasmussen A, Bundgaard H, Garred P, Iversen K, Nielsen SD. Decline in Antibody Concentration 6 Months After Two Doses of SARS-CoV-2 BNT162b2 Vaccine in Solid Organ Transplant Recipients and Healthy Controls. Front Immunol. 2022 Feb 23;13:832501. doi: 10.3389/fimmu.2022.832501.
Hansen CB, Jarlhelt I, Hasselbalch RB, Hamm SR, Fogh K, Pries-Heje MM, Møller DL, Heftdal LD, Pérez-Alós L, Sørensen E, Larsen MAH, Skjoedt MO, Ostrowski SR, Frikke-Schmidt R, Bayarri-Olmos R, Hilsted LM, Bundgaard H, Nielsen SD, Iversen KK, Garred P. Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming. J Intern Med. 2021 Dec;290(6):1272-1274. doi: 10.1111/joim.13366. Epub 2021 Aug 2.
Bayarri-Olmos R, Jarlhelt I, Johnsen LB, Hansen CB, Helgstrand C, Rose
Bjelke J, Matthiesen F, Nielsen SD, Iversen KK, Ostrowski SR, Bundgaard H,
Frikke-Schmidt R, Garred P, Skjoedt MO. Functional Effects of Receptor-Binding
Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants. Front Immunol. 2021 Oct
7;12:757197. doi: 10.3389/fimmu.2021.757197.
Kvist-Hansen A, Hansen CB, Hamm SR, Pérez-Alós L, Zachariae C, Nielsen SD, Garred P, Skov L. Humoral immunity after a booster dose of COVID-19 vaccine in patients with psoriasis treated with methotrexate and biologics: a cohort study. Clin Exp Dermatol. 2024 Aug 22:llae349. doi: 10.1093/ced/llae349. Epub ahead of print. PMID: 39172535.
Hamm SR, Loft JA, Pérez-Alós L, Heftdal LD, Hansen CB, Møller DL, Pries-Heje MM, Hasselbalch RB, Fogh K, Hald A, Ostrowski SR, Frikke-Schmidt R, Sørensen E, Hilsted L, Bundgaard H, Garred P, Iversen K, Perch M, Sørensen SS, Rasmussen A, Sabin CA, Nielsen SD. The Impact of Time between Booster Doses on Humoral Immune Response in Solid Organ Transplant Recipients Vaccinated with BNT162b2 Vaccines. Viruses. 2024 May 28;16(6):860. doi: 10.3390/v16060860. PMID: 38932153; PMCID: PMC11209529.
Heftdal LD, Hansen CB, Hamm SR, Pérez-Alós L, Fogh K, Pries-Heje M, Hasselbalch RB, Møller DL, Gang AO, Ostrowski SR, Frikke-Schmidt R, Sørensen E, Hilsted L, Bundgaard H, Garred P, Iversen K, Sabin C, Nielsen SD, Grønbæk K. Humoral Immune Responses after an Omicron-Adapted Booster BNT162b2 Vaccination in Patients with Lymphoid Malignancies. Viruses. 2023 Dec 20;16(1):11. doi: 10.3390/v16010011. PMID: 38275946; PMCID: PMC10820239.
Holm-Yildiz S, Dysgaard T, Krag T, Pedersen BS, Hamm SR, Pérez-Alós L, Hansen CB, Pries-Heje MM, Heftdal LD, Hasselbalch RB, Fogh K, Madsen JR, Frikke-Schmidt R, Hilsted LM, Sørensen E, Ostrowski SR, Bundgaard H, Garred P, Iversen K, Nielsen SD, Vissing J. Humoral immune response to COVID-19 vaccine in patients with myasthenia gravis. J Neuroimmunol. 2023 Nov 15;384:578215. doi: 10.1016/j.jneuroim.2023.578215. Epub 2023 Sep 28. PMID: 37797472.
Jarlhelt I, Pérez-Alós L, Bayarri-Olmos R, Hansen CB, Petersen MS, Weihe P, Armenteros JJA, Madsen JR, Nielsen JPS, Hilsted LM, Iversen KK, Bundgaard H, Nielsen SD, Garred P. Distinguishing SARS-CoV-2 infection and vaccine responses up to 18 months post-infection using nucleocapsid protein and receptor-binding domain antibodies. Microbiol Spectr. 2023 Sep 22;11(5):e0179623. doi: 10.1128/spectrum.01796-23. Epub ahead of print. PMID: 37738355; PMCID: PMC10580960.
Pérez-Alós L, Hansen CB, Almagro Armenteros JJ, Madsen JR, Heftdal LD, Hasselbalch RB, Pries-Heje MM, Bayarri-Olmos R, Jarlhelt I, Hamm SR, Møller DL, Sørensen E, Ostrowski SR, Frikke-Schmidt R, Hilsted LM, Bundgaard H, Nielsen SD, Iversen KK, Garred P. Previous immunity shapes immune responses to SARS-CoV-2 booster vaccination and Omicron breakthrough infection risk. Nat Commun. 2023 Sep 12;14(1):5624. doi: 10.1038/s41467-023-41342-2. PMID: 37699890; PMCID: PMC10497567.
Heftdal LD, Pérez-Alós L, Hasselbalch RB, Hansen CB, Hamm SR, Møller DL, Pries-Heje M, Fogh K, Gerstoft J, Grønbæk K, Ostrowski SR, Frikke-Schmidt R, Sørensen E, Hilsted L, Bundgaard H, Garred P, Iversen K, Sabin C, Nielsen SD. Humoral and cellular immune responses eleven months after the third dose of BNT162b2 an mRNA-based COVID-19 vaccine in people with HIV - a prospective observational cohort study. EBioMedicine. 2023 Jul;93:104661. doi: 10.1016/j.ebiom.2023.104661. Epub 2023 Jun 16. PMID: 37331161; PMCID: PMC10272831.
Heftdal LD, Hamm SR, Pérez-Alós L, Madsen JR, Armenteros JJA, Fogh K, Kronborg CC, Vallentin AP, Hasselbalch RB, Møller DL, Hansen CB, Pries-Heje M, Gang AO, Ostrowski SR, Frikke-Schmidt R, Sørensen E, Hilsted L, Bundgaard H, Iversen K, Garred P, Nielsen SD, Grønbaek K. Humoral and cellular immune responses after three or four doses of BNT162b2 in patients with hematological malignancies. Eur J Haematol. 2023 Aug;111(2):229-239. doi: 10.1111/ejh.13986. Epub 2023 May 8. PMID: 37151174.