Gå til hovedindhold

​​​​

COCOMO-studiet

Copenhagen comorbidity in HIV infection (COCOMO) studiet.

​​

Formålet med COCOMO-studiet er at undersøge forekomsten af anden samtidig sygdom (infektiøs og ikke-infektiøs komorbiditet) blandt personer, der lever med HIV og bor i Københavnsområdet. 

Studiet blev igangsat i 2015, og 1099 personer med HIV fra Hvidovre Hospital og Rigshospitalet valgte at deltage. Alle deltagere svarede på et spørgeskema og fik lavet et helbredstjek med bl.a. blodprøver, pusteprøve (spirometri) og skanning af hjerte og lunger (CT). Siden har omkring 90 % af deltagerne været med i en opfølgende helbredsundersøgelse i 2017-2018 med mulighed for at få foretaget ultralydsscanning (ekkokardiografi) af hjertet.
​Til dato er 49 artikler med data fra COCOMO-studiet blevet publiceret i internationale fagfællebedømte tidsskrifter. Et udpluk af hovedfundene kan ses nedenfor. 

Hjertesygdom

Flere personer med HIV får med alderen forandringer på deres ekg, har højere forekomst af åreforkalkningssygdom i benene, forhøjet blodtryk i lungerne, forstørret hjertemuskel og højere risiko for udposning på hovedpulsåren. Alt sammen tegn på begyndende eller manifest hjertekarsygdom. ​​

Lungesygdom

Personer med HIV har en højere forekomst af kronisk obstruktiv lungesygdom (KOL) end HIV-negative personer. Risikofaktorerne for at udvikle KOL er de samme som i baggrundsbefolkningen, men rygning ser ud til have en større skadelig effekt på lungerne hos personer med HIV end hos HIV-negative. Der er ikke tegn på, at personer med HIV er i øget risiko for at have beskadiget lungevæv (emfysem) eller lungetumorer.

Lever- og nyresygdom 

Vi har fundet, at personer med HIV har højere forekomst af leverfibrose (arvæv) end HIV-negative personer, mens forekomst af fedtlever er lavere. Sandsynligheden for at have nedsat nyrefunktion var mere end tre gange højere for personer med HIV sammenlignet med HIV-negative personer.

Metabolisme

Personer med HIV har højere forekomst af abdominal fedme og metabolisk sygdom, som er velkendte risikofaktorer for kardiovaskulære sygdomme. Vi har fundet, at tidligere anvendte HIV-behandlinger er forbundet med mere fedt omkring tarmene, selv mange år efter behandlingen er stoppet. Opstart af nyere behandling medfører først vægtøgning, men effekten aftager over tid, og langtidsbrug medfører ikke øget vægtøgning.

Hormonsygdomme og blodsygdomme 

Vi har fundet, at personer med HIV har højere forekomst af sukkersyge end HIV-negative personer. Der er ingen tegn på, at stofskiftesygdomme skulle være mere hyppige hos personer med HIV, end sammenlignelige HIV-negative personer, men flere har blodmangel og/eller forstyrrelser i blodets evne til at størkne. Knogleskørhed findes hyppigere hos personer med HIV end hos HIV-negative personer, men når man tager højde for risikofaktorer såsom rygning, er der ingen forskel i knogleskørhed.

Inflammation og tryptofanmetabolisme

Vi har fundet, at forstyrret tryptofanmetabolisme er forbundet med fedme, depression og ændringer i tarmmikrobiom.

​Afdeling for Infektionssygdomme, Rigshospitalet

  • Susanne Dam Poulsen, klinisk professor, overlæge
  • Andreas Dehlbæk Knudsen, Læge, ph.d. 
  • Marco Gelpi, læge, ph.d.
  • Anne Marie Reimer Jensen, læge, ph.d.-studerende
  • Moises Alberto Suarez Zdunek, læge, ph.d.-studerende
  • Malene Hove-Skovsgaard, læge, ph.d.-studerende

Afdeling for Infektionssygdomme, Hvidovre Hospital

  • Thomas Benfield, klinsk professor, overlæge

Afdeling for Hjertesygdomme, Rigshospitalet 

  • Klaus Kofoed, klinisk lektor, læge
  • Lars Køber, klinisk professor, læge

Afdeling for Hjertesygdomme, Herlev-Gentofte Hospital

  • Tor Biering-Sørensen, professor, læge 

​Afdeling for Klinisk Biokemi, Herlev-Gentofte Hospital

  • Børge Nordestgaard, klinisk professor, læge
  • Shoaib Afzal, læge, ph.d.

Section of Clinical Immunology and Infectious Diseases, Oslo Universitetshospital, Oslo, Norge 

  • Marius Trøseid, professor, overlæge 

Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sverige

  • Ujjwal Neogi, lektor

Institute for Global Health, University College London, London, England

  • Caroline Sabin, professor

Bevillinger
  • Lundbeck Fonden
  • Novo Nordisk Fonden 
  • Region Hovedstaden
  • Rigshospitalet Forskningsudvalg
  • Augustinus Fonden 
  • Gilead
  • Skibsreder Per Henriksen, R. og hustrus fond 
  • Åse og Ejnar Danielsens Fond

Har du spørgsmål til projektet, der ikke indeholder følsomme og fortrolige oplysninger, kan du skrive til os via e-mail:  cocomo.rigshospitalet@regionh.dk​

​Igangværende ph.d.-projekter

  • ”Cardiac structure and function in people living with HIV” - Anne Marie Reimer Jensen, Læge, Ph.D.-studerende
  • ​”Residual immune dysfunctions in people living with HIV with suppressed viral replication” - Malene Hove-Skovsgaard, Læge, Ph.D.-studerende
  • “Cytomegalovirus Infection and Coronary Artery Disease in Immunosuppressed Patients" - Moises Alberto Suarez Zdunek, læge, ph.d.-studerende​

Afsluttede Ph.d.-projekter

  • ” Chronic airflow limitation in people living with HIV” – Andreas Ronit, Læge, Ph.D.
  • ”Biomarkers and cardiovascular disease in HIV infection” – Judith Melchior Haissman, Læge, Ph.D.
  • ” Non-Alcoholic Fatty Liver Disease and Fibrosis in HIV Infection” – Ditte Marie Kirkegaard-Klitbo, Læge, Ph.D.
  • ” Gut microbiota, visceral adipose tissue accumulation, and metabolic syndrome in people living with HIV” – Marco Gelpi, Læge, Ph.D.
  • ” Cardiovascular Co-morbidity in Persons living with HIV in Copenhagen” – Andreas Dehlbæk Knudsen, Læge, Ph.D.
  • ” Inflammation and lung function impairment in people living with HIV” – Rebekka Faber Thudium, Læge, Ph.D.
  • ” Gut microbiota, extracellular vesicles and comorbidities in HIV infection” – Beate Vestad, Læge, Ph.D.

​Publikationer

  1. Ronit A, Klitbo DM, Kildemoes AO, Benfield T, Gerstoft J, Vestbo J, Jensen JS, Kurtzhals J, Nielsen SD. Absence of Pneumocystis jirovecii Colonization in Human Immunodeficiency Virus-Infected Individuals With and Without Airway Obstruction and With Undetectable Viral Load. Open Forum Infect Dis. 2016 Feb 19;3(1):ofw044. doi: 10.1093/ofid/ofw044.
  2. Ronit A, Haissman J, Kirkegaard-Klitbo DM, Kristensen TS, Lebech AM, Benfield T, Gerstoft J, Ullum H, Køber L, Kjær A, Kofoed K, Vestbo J, Nordestgaard B, Lundgren J, Nielsen SD. Copenhagen comorbidity in HIV infection (COCOMO) study: a study protocol for a longitudinal, non-interventional assessment of non-AIDS comorbidity in HIV infection in Denmark. BMC Infect Dis. 2016 Nov 26;16(1):713. doi: 10.1186/s12879-016-2026-9. 
  3. Ronit A, Kristensen T, Klitbo DM, Gelpi M, Kalhauge A, Benfield T, Gerstoft J, Lundgren J, Vestbo J, Kofoed KF, Nielsen SD. Incidental lung cancers and positive computed tomography images in people living with HIV. AIDS. 2017 Sep 10;31(14):1973-1977. doi: 10.1097/QAD.0000000000001600. 
  4. Ronit A, Kristensen T, Çolak Y, Kühl JT, Kalhauge A, Lange P, Nordestgaard, BG, Vestbo J, Nielsen SD, Kofoed KF. Validation of lung density indices by cardiac CT for quantification of lung emphysema. Int J Chron Obstruct Pulmon Dis. 2018 Oct 11;13:3321-3330. doi: 10.2147/COPD.S172695. 
  5. Ronit A, Lundgren J, Afzal S, Benfield T, Roen A, Mocroft A, Gerstoft J, Nordestgaard BG, Vestbo J, Nielsen SD; Copenhagen Co-morbidity in HIV infection (COCOMO) study group. Airflow limitation in people living with HIV and matched uninfected controls. Thorax. 2018 May;73(5):431-438. doi: 10.1136/thoraxjnl-2017-211079. Epub 2018 Jan 13. 
  6. Ronit A, Kristensen T, Hoseth VS, Abou-Kassem D, Kühl JT, Benfield T, Gerstoft J, Afzal S, Nordestgaard BG, Lundgren JD, Vestbo J, Kofoed KF, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) study group. Computed tomography quantification of emphysema in people living with HIV and uninfected controls. Eur Respir J. 2018 Jul 19;52(1):1800296. doi: 10.1183/13993003.00296-2018. 
  7. Gelpi M, Afzal S, Lundgren J, Ronit A, Roen A, Mocroft A, Gerstoft J, Lebech AM, Lindegaard B, Kofoed KF, Nordestgaard BG, Nielsen SD. Higher Risk of Abdominal Obesity, Elevated Low-Density Lipoprotein Cholesterol, and Hypertriglyceridemia, but not of Hypertension, in People Living With Human Immunodeficiency Virus (HIV): Results From the Copenhagen Comorbidity in HIV Infection Study. Clin Infect Dis. 2018 Aug 1;67(4):579-586. doi: 10.1093/cid/ciy146. 
  8. Harsløf M, Knudsen AD, Benfield T, Nordestgaard BG, Feldt-Rasmussen U, Nielsen SD. No evidence of increased risk of thyroid dysfunction in well treated people living with HIV. AIDS. 2018 Sep 24;32(15):2195-2199. doi: 10.1097/QAD.0000000000001954. 
  9. Ronit A, Ahlström MG, Knudsen AD, Gerstoft J, Nordestgaard BG, Benfield T, Nielsen SD. HIV Status Is a Greater Determinant of Low Self-perceived Life Expectancy Than Cigarette Smoking in a Well-resourced Setting. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):e81-e84. doi: 10.1097/QAI.0000000000001784. PMID: 30212439.
  10. Knudsen AD, Gelpi M, Afzal S, Ronit A, Roen A, Mocroft A, Lundgren J, Nordestgaard B, Sillesen H, Lebech AM, Køber L, Kofoed KF, Nielsen SD. Brief Report: Prevalence of Peripheral Artery Disease Is Higher in Persons Living With HIV Compared With Uninfected Controls. J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):381-385. doi: 10.1097/QAI.0000000000001795. 
  11. Ronit A, Benfield T, Mocroft A, Gerstoft J, Nordestgaard BG, Vestbo J, Nielsen SD; Copenhagen Co-morbidity in HIV Infection (COCOMO) Study Group. Diagnostic performance of clinical characteristics to detect airflow limitation in people living with HIV and in uninfected controls. HIV Med. 2018 Nov;19(10):751-755. doi: 10.1111/hiv.12669. Epub 2018 Aug 30. 
  12. Thudium RF, Lundgren J, Benfield T, Nordestgaard BG, Borges ÁH, Gerstoft J, Nielsen SD, Ronit A; Copenhagen Co-morbidity in HIV Infection (COCOMO) Study Group. HIV infection is independently associated with a higher concentration of alpha-1 antitrypsin. HIV Med. 2018 Nov;19(10):745-750. doi: 10.1111/hiv.12666. Epub 2018 Aug 30. 
  13. Gelpi M, Afzal S, Fuchs A, Lundgren J, Knudsen AD, Drivsholm N, Mocroft A, Lebech AM, Lindegaard B, Kühl JT, Sigvardsen PE, Køber L, Nordestgaard BG, Kofoed KF, Nielsen SD. Prior exposure to thymidine analogs and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors. AIDS. 2019 Mar 15;33(4):675-683. doi: 10.1097/QAD.0000000000002119. 
  14. Gelpi M, Knudsen AD, Larsen KB, Mocroft A, Lebech AM, Lindegaard B, Lundgren J, Kofoed KF, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) Study. Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure. BMC Infect Dis. 2019 Aug 9;19(1):708. doi: 10.1186/s12879-019-4347-y. 
  15. Akdag D, Knudsen AD, Thudium RF, Kirkegaard-Klitbo DM, Nielsen C, Brown P, Afzal S, Nordestgaard BG, Lundgren J, Nielsen SD. Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People With Human Immunodeficiency Virus and Well-Controlled Viral Replication. J Infect Dis. 2019 Oct 22;220(11):1834-1842. doi: 10.1093/infdis/jiz394. 
  16. Petersen N, Knudsen AD, Mocroft A, Kirkegaard-Klitbo D, Arici E, Lundgren J, Benfield T, Oturai P, Nordestgaard BG, Feldt-Rasmussen B, Nielsen SD, Ryom L. Prevalence of impaired renal function in virologically suppressed people living with HIV compared with controls: the Copenhagen Comorbidity in HIV Infection (COCOMO) study. HIV Med. 2019 Nov;20(10):639-647. doi: 10.1111/hiv.12778. Epub 2019 Jul 29. 
  17. Knudsen AD, Kofoed KF, Gelpi M, Sigvardsen PE, Mocroft A, Kühl JT, Fuchs A, Køber L, Nordestgaard BG, Benfield T, Graff C, Skov MW, Lundgren J, Nielsen SD; Copenhagen Comorbidity in HIV Infection (COCOMO) Study. Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV. AIDS. 2019 Nov 15;33(14):2205-2210. doi: 10.1097/QAD.0000000000002327. 
  18. Rezahosseini O, Knudsen AD, Gelpi M, Ronit A, Ueland PM, Midttun Ø, Kirkegaard-Klitbo DM, Ullum H, Nielsen SD. Plasma Cotinine Cutoff for Distinguishing Smokers From Nonsmokers Among Persons Living With HIV. J Acquir Immune Defic Syndr. 2019 Dec 15;82(5):e54-e56. doi: 10.1097/QAI.0000000000002189. 
  19. Gelpi M, Ueland PM, Trøseid M, Mocroft A, Lebech AM, Ullum H, Midttun Ø, Lundgren J, Nielsen SD. Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. J Infect Dis. 2020 Jan 14;221(3):419-427. doi: 10.1093/infdis/jiz465. 
  20. Thomsen MT, Wiegandt YL, Gelpi M, Knudsen AD, Fuchs A, Sigvardsen PE, Kühl JT, Nordestgaard B, Køber L, Lundgren J, Hansen AE, Kofoed KF, Jensen JB, Nielsen SD. Prevalence of and Risk Factors for Low Bone Mineral Density Assessed by Quantitative Computed Tomography in People Living With HIV and Uninfected Controls. J Acquir Immune Defic Syndr. 2020 Feb 1;83(2):165-172. doi: 10.1097/QAI.0000000000002245. 
  21. Ronit A, Benfield T, Lundgren J, Vestbo J, Afzal S, Nordestgaard BG, Kühl JT, Kofoed KF, Nielsen SD, Kristensen T. Interstitial Lung Abnormalities in People With HIV Infection and Uninfected Controls. J Infect Dis. 2020 Jun 11;221(12):1973-1977. doi: 10.1093/infdis/jiaa047. 
  22. Knudsen AD, Krebs-Demmer L, Bjørge NID, Elming MB, Gelpi M, Sigvardsen PE, Lebech AM, Fuchs A, Kühl JT, Køber L, Lundgren J, Nordestgaard BG, Kofoed KF, Nielsen SD. Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir. J Infect Dis. 2020 Jun 16;222(1):54-61. doi: 10.1093/infdis/jiaa057. 
  23. Kirkegaard-Klitbo DM, Fuchs A, Stender S, Sigvardsen PE, Kühl JT, Kofoed KF, Køber L, Nordestgaard BG, Bendtsen F, Mocroft A, Lundgren J, Nielsen SD, Benfield T. Prevalence and Risk Factors of Moderate-to-Severe Hepatic Steatosis in Human Immunodeficiency Virus Infection: The Copenhagen Co-morbidity Liver Study. J Infect Dis. 2020 Sep 14;222(8):1353-1362. doi: 10.1093/infdis/jiaa246. PMID: 32417886.
  24. Hove-Skovsgaard M, Zhao Y, Tingstedt JL, Hartling HJ, Thudium RF, Benfield T, Afzal S, Nordestgaard B, Ullum H, Gerstoft J, Mocroft A, Nielsen SD. Impact of Age and HIV Status on Immune Activation, Senescence and Apoptosis. Front Immunol. 2020 Sep 30;11:583569. doi: 10.3389/fimmu.2020.583569. 
  25. Krebs-Demmer L, Ronit A, Sigvardsen PE, Lebech AM, Gerstoft J, Knudsen AD, Fuchs A, Kühl JT, Nordestgaard BG, Kofoed KF, Nielsen SD. Cardiac chamber volumes and left ventricular mass in people living with HIV and matched uninfected controls. HIV Med. 2020 Nov;21(10):625-634. doi: 10.1111/hiv.12916. Epub 2020 Sep 9. 
  26. Gelpi M, Vestad B, Hansen SH, Holm K, Drivsholm N, Goetz A, Kirkby NS, Lindegaard B, Lebech AM, Hoel H, Michelsen AE, Ueland T, Gerstoft J, Lundgren J, Hov JR, Nielsen SD, Trøseid M. Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions. Clin Infect Dis. 2020 Nov 5;71(8):e359-e367. doi: 10.1093/cid/ciz1235. 
  27. Hove-Skovsgaard M, Abildgaard J, Gelpi M, Gaardbo JC, Kolte L, Ullum H, Trøseid M, Lindegaard B, Nielsen SD. No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers. BMC Infect Dis. 2020 Nov 25;20(1):882. doi: 10.1186/s12879-020-05594-3. PMID: 33238950; PMCID: PMC7687725.
  28. Kirkegaard-Klitbo DM, Bendtsen F, Lundgren J, Nielsen SD, Benfield T; COCOMO study group. Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis. Clin Gastroenterol Hepatol. 2020 Dec;18(13):3049-3050. doi: 10.1016/j.cgh.2019.10.024. Epub 2019 Oct 21.
  29. Thudium RF, Hughes NLP, Afzal S, Çolak Y, Gelpi M, Knudsen AD, Kirkegaard-Klitbo DM, Borges ÁH, Gerstoft J, Nordestgaard BG, Vestbo J, Lundgren J, Ronit A, Nielsen SD. Fraction of Exhaled Nitric Oxide Levels Are Elevated in People Living With Human Immunodeficiency Virus Compared to Uninfected Controls, Suggesting Increased Eosinophilic Airway Inflammation. Clin Infect Dis. 2020 Dec 15;71(12):3214-3221. doi: 10.1093/cid/ciz1223. 
  30. Knudsen AD, Ronit A, Kristensen T, Thomsen MT, Lebech AM, Cuong MH, Sigvardsen PE, Kühl JT, Fuchs A, Køber L, Lundgren J, Vestbo J, Kofoed KF, Nielsen SD. Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus. J Infect Dis. 2021 Jan 4;223(1):94-100. doi: 10.1093/infdis/jiaa339. 
  31. Fink A, Knudsen AD, Thudium RF, Von Stemann JH, Afzal S, Lundgren J, Kirkegaard-Klitbo DM, Ostrowski SR, Nordestgaard BG, Nielsen SD. Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication. Sci Rep. 2021 Feb 23;11(1):4383. doi: 10.1038/s41598-021-83731-x. 
  32. Thudium RF, Ringheim H, Ronit A, Hoel H, Benfield T, Mocroft A, Gerstoft J, Trøseid M, Borges ÁH, Ostrowski SR, Vestbo J, Nielsen SD. Independent Associations of Tumor Necrosis Factor-Alpha and Interleukin-1 Beta With Radiographic Emphysema in People Living With HIV. Front Immunol. 2021 Apr 14;12:668113. doi: 10.3389/fimmu.2021.668113. 
  33. Thudium RF, Knudsen AD, Von Stemann JH, Hove-Skovsgaard M, Hoel H, Mocroft A, Reekie J, Ronit A, Gerstoft J, Vestbo J, Trøseid M, Borges ÁH, Ostrowski SR, Nielsen SD. Independent Association of Interleukin 6 With Low Dynamic Lung Function and Airflow Limitation in Well-Treated People With Human Immunodeficiency Virus. J Infect Dis. 2021 May 28;223(10):1690-1698. doi: 10.1093/infdis/jiaa600. 
  34. Drivsholm N, Knudsen AD, Faurholt-Jepsen M, Midttun Ø, Trøseid M, Kirkegaard-Klitbo DM, Ueland PM, Nielsen SD, Gelpi M. Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. J Acquir Immune Defic Syndr. 2021 Jun 1;87(2):e177-e181. doi: 10.1097/QAI.0000000000002664. 
  35. Kirkegaard-Klitbo DM, Bendtsen F, Lundgren J, de Knegt RJ, Kofoed KF, Nielsen SD, Benfield T. Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls. J Infect Dis. 2021 Aug 2;224(3):443-452. doi: 10.1093/infdis/jiaa763. 
  36. Kirkegaard-Klitbo DM, Thomsen MT, Gelpi M, Bendtsen F, Nielsen SD, Benfield T. Hepatic Steatosis Associated With Exposure to Elvitegravir and Raltegravir. Clin Infect Dis. 2021 Aug 2;73(3):e811-e814. doi: 10.1093/cid/ciab057. 
  37. Høgh J, Pham MHC, Knudsen AD, Thudium RF, Gelpi M, Sigvardsen PE, Fuchs A, Kühl JT, Afzal S, Nordestgaard BG, Benfield T, Køber L, Gerstoft J, Kofoed KF, Nielsen SD. HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study. Eur Heart J. 2021 Aug 7;42(30):2924-2931. doi: 10.1093/eurheartj/ehab348. 
  38. Gelpi M, Mikaeloff F, Knudsen AD, Benfeitas R, Krishnan S, Svenssson Akusjärvi S, Høgh J, Murray DD, Ullum H, Neogi U, Nielsen SD. The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome. Aging (Albany NY). 2021 Oct 11;13(19):22732-22751. doi: 10.18632/aging.203622. Epub 2021 Oct 11. 
  39. Knudsen AD, Graff C, Nielsen JB, Thomsen MT, Høgh J, Benfield T, Gerstoft J, Køber L, Kofoed KF, Nielsen SD. De novo electrocardiographic abnormalities in persons living with HIV. Sci Rep. 2021 Oct 21;11(1):20750. doi: 10.1038/s41598-021-00290-x. 
  40. Høgh J, Gelpi M, Hove-Skovsgaard M, Afzal S, Nordestgaard BG, Gerstoft J, Benfield T, Storgaard H, Nielsen SD. HIV Infection Is Associated With Type 2 Diabetes Mellitus. J Acquir Immune Defic Syndr. 2021 Dec 1;88(4):e32-e35. doi: 10.1097/QAI.0000000000002798. 
  41. Sørensen EW, Gelpi M, Knudsen AD, Benfield T, Mocroft A, Nielsen SD. Switch to INSTIs, but Not Long-Term Stable INSTIs, Is Associated With Excess Weight Gain in People Living With HIV. J Acquir Immune Defic Syndr. 2021 Dec 15;88(5):e36-e38. doi: 10.1097/QAI.0000000000002802. 
  42. Olund Villumsen S, Benfeitas R, Knudsen AD, Gelpi M, Høgh J, Thomsen MT, Murray D, Ullum H, Neogi U, Nielsen SD. Integrative Lipidomics and Metabolomics for System-Level Understanding of the Metabolic Syndrome in Long-Term Treated HIV-Infected Individuals. Front Immunol. 2022 Jan 12;12:742736. doi: 10.3389/fimmu.2021.742736. 
  43. Knudsen AD, Bouazzi R, Afzal S, Gelpi M, Benfield T, Høgh J, Thomsen MT, Trøseid M, Nordestgaard BG, Nielsen SD. Monocyte count and soluble markers of monocyte activation in people living with HIV and uninfected controls. BMC Infect Dis. 2022 May 11;22(1):451. doi: 10.1186/s12879-022-07450-y. PMID: 35546661; PMCID: PMC9097376.
  44. Høgh J, Hove-Skovsgaard M, Gelpi M, Jensen AMR, Gerstoft J, Benfield T, Storgaard H, Nielsen SD. Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. BMC Infect Dis. 2022 May 28;22(1):503. doi: 10.1186/s12879-022-07485-1. PMID: 35643429; PMCID: PMC9145097.
  45. Gelpi M, Vestad B, Raju SC, Hansen SH, Høgh J, Midttun Ø, Ueland PM, Ueland T, Benfield T, Kofoed KF, Hov JR, Trøseid M, Nielsen SD. Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation. J Infect Dis. 2022 Jun 1;225(11):1948-1954. doi: 10.1093/infdis/jiac018. 
  46. Suarez-Zdunek MA, Høgh J, Kirkegaard-Klitbo DM, Jensen AMR, Rupert A, Trøseid M, Gerstoft J, Nielsen SD, Knudsen AD. High incidence of subclinical peripheral artery disease in people with HIV. AIDS. 2022 Aug 1;36(10):1355-1362. doi: 10.1097/QAD.0000000000003252. Epub 2022 May 25. PMID: 35608109.
  47. Hove-Skovsgaard M, Møller DL, Hald A, Gerstoft J, Lundgren J, Ostrowski SR, Nielsen SD. Improved induced innate immune response after cART initiation in people with HIV. Front Immunol. 2022 Aug 17;13:974767. doi: 10.3389/fimmu.2022.974767. 
  48. Thudium RF, Ronit A, Afzal S, Çolak Y, Forman JL, Mendo F, Chen F, Estrada V, Kumarasamy N, Nordestgaard BG, Lundgren J, Vestbo J, Kunisaki KM, Nielsen SD; COCOMO, INSIGHT START Pulmonary Substudy and CGPS Study Groups. Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study. Thorax. 2023 Jan 13:thoraxjnl-2022-218910. doi: 10.1136/thorax-2022-218910. Epub ahead of print. 
  49. Grønbæk SK, Høgh J, Knudsen AD, Pham MHC, Sigvardsen PE, Fuchs A, Kühl JT, Køber L, Gerstoft J, Benfield T, Ostrowski SR, Kofoed KF, Nielsen SD. Aortic aneurysms and markers of platelet activation, hemostasis, and endothelial disruption in people living with HIV. Front Immunol. 2023 Feb 2;14:1115894. doi: 10.3389/fimmu.2023.1115894. 
  50. Mikaeloff F, Gelpi M, Benfeitas R, Knudsen AD, Vestad B, Høgh J, Hov JR, Benfield T, Murray D, Giske CG, Mardinoglu A, Trøseid M, Nielsen SD, Neogi U. Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection. Elife. 2023 Feb 16;12:e82785. doi: 10.7554/eLife.82785. 
  51. Bundgård J, Reimer Jensen AM, Suarez-Zdunek MA, Høgh J, Gerstoft J, Benfield T, Ostrowski SR, Nielsen SD, Knudsen AD. Peripheral artery disease and markers of endothelial dysfunction and platelet activation in people with HIV. J Acquir Immune Defic Syndr. 2023 Mar 23. doi: 10.1097/QAI.0000000000003194. Epub ahead of print.
  52. Knudsen AD, Fuchs A, Benfield T et al. Coronary Artery Disease in Persons With Human Immunodeficiency Virus Without Detectable Viral Replication. Open Forum Infect Dis. 2023;10(7):ofad298. doi: 10.1093/ofid/ofad298
  53. Gelpi M, Karvig LU, Knudsen AD et al. Incidence of hypertension in people with HIV infection: a longitudinal observational study. AIDS. 2023;37(11):1705-1709. doi: 10.1097/QAD.0000000000003609
  54. Mikaeloff F, Gelpi M, Escos A et al. Transcriptomics age acceleration in prolonged treated HIV infection. Aging Cell 2023;22(10):e13951. doi: 10.1111/acel.13951
  55. Thudium RF, Arentoft NS, Hoel H et al. Elevated Levels of Interleukin-1β and Interleukin-10 Are Associated With Faster Lung Function Decline in People With Well-Treated Human Immunodeficiency Virus. J Infect Dis 2023;228(8):1080-1088. doi: 10.1093/infdis/jiad233
  56. Heidari SL, Hove-Skovsgaard M, Arentoft NS et al. Incidence of bacterial respiratory infection and pneumonia in people with HIV with and without airflow limitation. Int J Infect Dis 2024;139:183-191. doi: 10.1016/j.ijid.2023.12.009
  57. Reimer Jensen AM, Frikke-Schmidt R, Gelpi M et al. Elevated plasma apolipoprotein E levels in people living with HIV: Associations with biomarkers and HIV-specific risk factors. Atherosclerosis 2024;390:117457. doi: 10.1016/j.atherosclerosis.2024.117457
  58. Trøseid M, Molinaro A, Gelpi M. Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV. J Infect Dis. 2024;229(3):898-907. doi: 10.1093/infdis/jiad604
  59. Knudsen AD, Eskelund CW, Benfield T et al. Clonal hematopoiesis of indeterminate potential in persons with HIV. AIDS 2024;38(4):487-495. doi: 10.1097/QAD.0000000000003788​
​​

​

Sidst opdateret:
Redaktør
Webgruppen på Rigshospitalet
Klik for at scrolle op eller ned p� siden G� til toppen af siden

Rigshospitalet

Rigshospitalet

Blegdamsvej 9

2100 København Ø

T 35 45 35 45

E

Rigshospitalet

Valdemar Hansens Vej 1-27

2600 Glostrup

T 38 63 38 63​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​