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Publications

See recent publications from the Laboratory of Reproductive Biology

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Mihajlovic M, Pásztor-Jánoska DK, Cadenas J, Adrados CS, Andersen CY, Kristensen SG, Lind JU. 3D culture of ovarian follicles in granular and nanofibrillar hydrogels. Biomater Adv. 2024 Aug 3;164:213987. doi: 10.1016/j.bioadv.2024.213987.

 

Subiran Adrados C, Olesen HØ, Olesen SV, Pors SE, Holtze S, Hildebrandt T, Andersen CY, Kristensen SG. Exploring the effect of platelet-rich plasma on vascularization and survival of follicles in xenotransplanted human ovarian tissue. Reprod Biomed Online. 2024 Oct;49(4):104274. doi: 10.1016/j.rbmo.2024.104274

 

Subiran Adrados C, Cadenas J, Polat SL, Tjäder AS, Blanche P, Kristensen SG. Exploring the potential use of platelet rich plasma (PRP) from adult and umbilical cord blood in murine follicle culture. Reprod Biol. 2024 Jan 17;24(1):100851.

 

Cadenas J, Pors SE, Hansen CP, Olufsen SM, Subiran C, Bøtkjær JA, La Cour Poulsen L, Fedder J, Dueholm M, Colmorn LB, Kristensen SG, Mamsen LS, Andersen CY. Midkine characterization in human ovaries: potential new variants in follicles. F S Sci. 2023 Sep 20:S2666-335X(23)00051-4. doi: 10.1016/j.xfss.2023.09.003.

 

Subiran Adrados C, Cadenas J, Zheng M, Lund S, Larsen EC, Tanvig MH, Greve VH, Blanche P, Andersen CY, Kristensen SG. Human platelet lysate improves the growth and survival of cultured human pre-antral follicles. Reprod Biomed Online. 2023 Jun 26;47(5):103256. doi: 10.1016/j.rbmo.2023.06.011.

 

Zheng M, Cadenas J, Pors SE, Esa T, Kristensen SG, Mamsen LS, Adrados CS, Andersen CY. Reducing 3D Hydrogel Stiffness, Addition of Oestradiol in a Physiological Concentration and Increasing FSH Concentration Improve In Vitro Growth of Murine Preantral Follicles. Int J Mol Sci. 2023 Aug 6;24(15):12499. doi: 10.3390/ijms241512499.

 

Colmorn LB, Kristensen SG, Larsen EC, Macklon KT. Cryopreservation of ovarian tissue as fertility preservation in young women with multiple sclerosis before stem cell transplantation. Mult Scler Relat Disord. 2023 Apr 11;74:104716.

 

Olesen HØ, Pors SE, Adrados CS, Zeuthen MC, Mamsen LS, Pedersen AT, Kristensen SG. Effects of needle puncturing on re-vascularization and follicle survival in xenotransplanted human ovarian tissue. Reprod Biol Endocrinol. 2023 Mar 20;21(1):28.

 

Colmorn LB, Pedersen AT, Larsen EC, Hansen AS, Rosendahl M, Andersen CY, Kristensen SG, Macklon KT. Reproductive and Endocrine Outcomes in a Cohort of Danish Women following Auto-Transplantation of Frozen/Thawed Ovarian Tissue from a Single Center. Cancers (Basel). 2022 Nov 29;14(23):5873.

 

Bøtkjær JA, Kristensen SG, Olesen HØ, Larsson P, Mannaerts B, Andersen CY. Dose-dependent stimulation of human follicular steroidogenesis by a novel rhCG during ovarian stimulation with fixed rFSH dosing. Front Endocrinol (Lausanne). 2022 Oct 20;13:1004596.

 

Pors SE, Nikiforov D, Cadenas J, Ghezelayagh Z, Wakimoto Y, Jara LAZ, Cheng J, Dueholm M, Macklon KT, Flachs EM, Mamsen LS, Kristensen SG, Andersen CY. Oocyte diameter predicts the maturation rate of human immature oocytes collected ex vivo. J Assist Reprod Genet. 2022 Sep 10.

 

Cadenas J, Pors SE, Kumar A, Kalra B, Kristensen SG, Andersen CY, Mamsen LS. Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM. Reprod Biol Endocrinol. 2022 Aug 19;20(1):126.

 

Ataman LM, Laronda MM, Gowett M, Trotter K, Anvari H, Fei F, Ingram A, Minette M, Suebthawinkul C, Taghvaei Z, Torres-Vélez M, Velez K, Adiga SK, Anazodo A, Appiah L, Bourlon MT, Daniels N, Dolmans MM, Finlayson C, Gilchrist RB, Gomez-Lobo V, Greenblatt E, Halpern JA, Hutt K, Johnson EK, Kawamura K, Khrouf M, Kimelman D, Kristensen SG, Mitchell RT, Moravek MB, Nahata L, Orwig KE, Pavone ME, Pépin D, Pesce R, Quinn GP, Rosen MP, Rowell E, Smith K, Venter C, Whiteside S, Xiao S, Zelinski M, Goldman KN, Woodruff TK, Duncan FE. A synopsis of global frontiers in fertility preservation. J Assist Reprod Genet. 2022 Aug;39(8):1693-1712.

 

Kristensen SG, Kumar A, Mamsen LS, Kalra B, Pors SE, Bøtkjær JA, Macklon KT, Fedder J, Ernst E, Hardy K, Franks S, Andersen CY. Intrafollicular concentrations of the oocyte-secreted factors GDF9 and BMP15 vary inversely in polycystic ovaries. J Clin Endocrinol Metab. 2022 May 2:dgac272.

 

Kristensen SG, Olesen HØ, Zeuthen MC, Pors SE, Andersen CY, Mamsen LS. Revascularization of human ovarian grafts is equally efficient from both sides of the cortex tissue. Reprod Biomed Online. 2022 Feb 15:S1472-6483(22)00093-1.

 

Pla I, Sanchez A, Pors SE, Kristensen SG, Appelqvist R, Sahlin KB, Marko-Varga G, Andersen CY, Malm J. Proteomic Alterations in Follicular Fluid of Human Small Antral Follicles Collected from Polycystic Ovaries-A Pilot Study. Life (Basel). 2022 Mar 8;12(3):391.

 

Khattak H, Malhas R, Craciunas L, Afifi Y, Amorim CA, Fishel S, Silber S, Gook D, Demeestere I, Bystrova O, Lisyanskaya A, Manikhas G, Lotz L, Dittrich R, Colmorn LB, Macklon KT, Hjorth IMD, Kristensen SG, Gallos I, Coomarasamy A. Fresh and cryopreserved ovarian tissue transplantation for preserving reproductive and endocrine function: a systematic review and individual patient data meta-analysis. Hum Reprod Update. 2022 Feb 24:dmac003.

 

Cadenas J, Pors SE, Nikiforov D, Zheng M, Subiran C, Bøtkjær JA, Mamsen LS, Kristensen SG, Andersen CY. Validating Reference Gene Expression Stability in Human Ovarian Follicles, Oocytes, Cumulus Cells, Ovarian Medulla, and Ovarian Cortex Tissue. Int J Mol Sci. 2022 Jan 14;23(2):886.

 

Colmorn LB, Kristensen SG, Dueholm M, Macklon KT. [Fertility preservation]. Ugeskr Laeger. 2021 Nov 29;183(48):V05210409

 

Hornshøj Greve V, Dueholm M, Mamsen LS, Kristensen SG, Ernst E, Andersen CY. Hormonal Characteristics of Women Receiving Ovarian Tissue Transplantation with or without Endogenous Ovarian Activity. J Clin Med. 2021 Nov 9;10(22):5217.

 

Gjeterud J, Kristensen SG, Fedder J. Indications for cryopreservation and autotransplantation of ovarian tissue. Tidsskr Nor Laegeforen. 2021 Oct 25;141(2021-15).

 

Pors SE, Kristensen SG, Nikiforov D, Mamsen LS, Cadenas J, Greve VH, Dueholm M, Andersen CY. Histidine buffered media maintains pH stabile during cooled transportation of human ovarian tissue. J Ovarian Res. 2021 Sep 3;14(1):116.

 

Mamsen LS, Olesen HØ, Pors SE, Hu X, Bjerring P, Christiansen K, Adrados CS, Andersen CY, Kristensen SG. Effects of Er:YAG laser treatment on re-vascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to immunodeficient mice. J Assist Reprod Genet. 2021 Aug 27.

 

Kristensen SG, Wakimoto Y, Colmorn LB, Dueholm M, Pors SE, Macklon KT, Mamsen LS, Nikiforov D, Cadenas J, Greve VH, Bay Bjørn AM, Rosendahl M, Pedersen AT, Nyboe Andersen A, Fedder J, Ernst E, Andersen CY. Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort. Fertil Steril. 2021 Jun 12:S0015-0282(21)00471-4.

 

Cadenas J, Nikiforov D, Pors SE, Zuniga LA, Wakimoto Y, Ghezelayagh Z, Mamsen LS, Kristensen SG, Andersen CY. A threshold concentration of FSH is needed during IVM of ex vivo collected human oocytes. J Assist Reprod Genet. 2021 May 28.

 

Nikiforov D, Cadenas J, Mamsen LS, Wakimoto Y, Kristensen SG, Pors SE, Andersen CY. Clusters of smooth endoplasmic reticulum are absent in oocytes from unstimulated women. Reprod Biomed Online. 2021 Mar 16:S1472-6483(21)00108-5.

 

Mamsen LS, Bøtkjær JA, Kristensen SG, Pors SE, Jeppesen JV, Kumar A, Kalra B, Ernst E, Andersen CY. High Variability of Molecular Isoforms of AMH in Follicular Fluid and Granulosa Cells From Human Small Antral Follicles. Front Endocrinol (Lausanne). 2021 Mar 2;12:617523.

 

Kristensen SG, Duncan FE. Autonomous follicle growth and the production of mature human eggs in vitro: with or without the ovary? Hum Reprod. 2021 Apr 20;36(5):1163-1165.

 

Mamsen LS, Kristensen SG, Pors SE, Bøtkjær JA, Ernst E, Macklon KT, Gook D, Kumar A, Kalra B, Andersen CY. Consequences of β-Thalassemia or Sickle Cell Disease for Ovarian Follicle Number and Morphology in Girls Who Had Ovarian Tissue Cryopreserved. Front Endocrinol (Lausanne). 2021 Jan 15;11:593718.

 

Practice Committee of the Oncofertility Consortium. Installing oncofertility programs for common cancers in optimum resource settings (Repro-Can-OPEN Study Part II): a committee opinion. J Assist Reprod Genet. 2021 Jan;38(1):163-176.

 

Subiran C, Kristensen SG, Andersen CY. Umbilical cord blood-derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum? Fertil Steril. 2021 Feb;115(2):336-337.

 

Olesen HØ, Pors SE, Jensen LB, Grønning AP, Lemser CE, Nguyen Heimbürger MTH, Mamsen LS, Getreu N, Christensen ST, Andersen CY, Kristensen SG. N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue. Hum Reprod. 2021 Jan 25;36(2):429-443

 

Hildorf S, Cortes D, Gül M, Dong L, Kristensen SG, Jensen CFS, Clasen-Linde E, Fedder J, Andersen CY, Hoffmann ER, Sønksen J, Fossum M, Thorup J. Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism. Sex Dev. 2019;13(5-6):246-257.

 

Bach AS, Macklon KT, Kristensen SG. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation. Reprod Biomed Online. 2020 Sep;41(3):555-565.

 

Dueholm Hjorth IM, Kristensen SG, Dueholm M, Humaidan P. Reproductive outcomes after in vitro fertilization treatment in a cohort of Danish women transplanted with cryopreserved ovarian tissue. Fertil Steril. 2020 Aug;114(2):379-387.

 

Goossens E, Jahnukainen K, Mitchell RT, van Pelt A, Pennings G, Rives N, Poels J, Wyns C, Lane S, Rodriguez-Wallberg KA, Rives A, Valli-Pulaski H, Steimer S, Kliesch S, Braye A, Andres MM, Medrano J, Ramos L, Kristensen SG, Andersen CY, Bjarnason R, Orwig KE, Neuhaus N, Stukenborg JB. Fertility preservation in boys: recent developments and new insights. Hum Reprod Open. 2020 Jun 6;2020(3):hoaa016.

 

Lunding SA, Andersen AN, Hardardottir L, Olesen HØ, Kristensen SG, Andersen CY, Pors SE. Hippo signaling, actin polymerization, and follicle activation in fragmented human ovarian cortex. Mol Reprod Dev. 2020 Jun;87(6):711-719..

 

Ketheeswaran S, Pors SE, Zuniga Jara LA, Lemser CE, Høj TK, Bøtkjær JA, Christensen P, Humaidan P, Kristensen SG. Effect of whey protein supplementation on sperm quality and fertility in male mice. Food Chem Toxicol. 2020  Jul;141:111366.

 

Pors SE, Harðardóttir L, Olesen HØ, Riis ML, Jensen LB, Andersen AS, Cadenas J, Grønning AP, Colmorn LB, Dueholm M, Andersen CY, Kristensen SG. Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue. Mol Hum Reprod. 2020 May 15;26(5):301-311.

 

Wakimoto Y, Pors SE, Cadenas J, Colmorn L, Ernst E, Dueholm M, Fedder J, Mamsen LS, Kristensen SG, Andersen CY. The precise ovarian volume is significantly associated with serum concentrations of antimüllerian hormone, the luteinizing hormone/follicle-stimulating hormone ratio, and total testosterone. Fertil Steril. 2020 Feb;113(2):453-459.

 

Nikiforov D, Junping C, Cadenas J, Shukla V, Blanshard R, Pors SE, Kristensen SG, Macklon KT, Colmorn L, Ernst E, Bay-Bjørn AM, Ghezelayagh Z, Wakimoto Y, Grøndahl ML, Hoffmann E, Andersen CY. Improving the maturation rate of human oocytes collected ex vivo during the cryopreservation of ovarian tissue. J Assist Reprod Genet. 2020 Apr;37(4):891-904.

 

Lunding SA, Pors SE, Kristensen SG, Bøtkjær JA, Ramløse M, Jeppesen JV, Flachs EM, Pinborg A, Macklon KT, Pedersen AT, Andersen CY, Andersen AN. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone. J Assist Reprod Genet. 2020 Jan;37(1):109-117.

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