All principal investigators are allowed to plan and conduct substudies and subsequent publications based on SafeBoosC-IIIv trial data. Substudies encompass secondary studies and ancillary studies. A secondary study draws solely on data from the SafeBoosC-IIIv database, while ancillary studies draw on data from the SafeBoosC-IIIv database, but also include data (additional variables or outcomes) that are not included in the original SafeBoosC-IIIv database. ​

Please contact the trial manager at caroline.kamp@ctu.dk if you are considering planning a substudy. Please see the Substudies and subsequent publications standard operating procedure​ for more information.

Approved substudies​​​

• Cerebral oximetry monitoring to detect hypocapnia in newborns undergoing invasive mechanical ventilation: a SafeBoosC-IIIv ancillary study​​​
  

  Current protocol: Protocol 1.​2 and Bed side data en​try form​
  Previous versions of the protocol: Prot​ocol 1.0
  

• The effects of treatment guided by cerebral oximetry monitoring on renal outcomes in invasively mechanically ventilated neonates: an ​​ancillary study of the SafeBoos​C-IIIv trial

  Current protocol: Protocol 1.2
  Previous versions of the protocol: Protocol​ 1.1​, Protocol 1.0​​
  

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