ENGLISH PGT (pre-implantation genetic testing), Trophectodermbiopsi - engelsk

Guidance for patients undergoing pre-implantation genetic testing.

Diagnosis on several cells

Today you have been through an oocyte pick-up in order to do pre-implantation genetic testing.

The day of the oocyt pick-up

We recommend that you relax for the rest of the day.

Please notice that you are not allowed to drive a car or ride a bike for the next 24 hours. The reason is that you have received medicine that makes you tired and a little inattentive.

After the oocyte pick-up you can expect some vaginal bleeding which may last a few days. The bleeding comes from the injection sites in the top of your vagina. It can be heavy the first day, but it is supposed to decrease during the day and evening. It is also normal to have menstrual pain.

You can take 1g of Paracetamol every 6.th hour. (2 x 500 mg tablets) if needed.

You are always welcome to call us if you have any questions.

If you experience any complications outside our opening hours, please call 1813.

Sexual intercourse should be avoided for the next couple of days as well as bathtub.

Most women will be able to go to work the day after oocyte pick-up.

The risk of infection is over when you have stopped bleeding and you may have a normal sex life.

It is important not to get spontaneous pregnant and you need to use contraception/ birth control.

The days after the oocyte pick-up

Your follicles will be refilled with fluid after a few days. It is normal that your stomach feels heavy, tender and bloated. It will be less after some time, but it may last up to 14 days. During the time when you feel affected after the procedure, it is recommended to reduce exercise and hard physical work.

It is important to drink up to two liters of fluid every day, for 10-14 days. (water, juice, milk products etc.)

 

On day 6.

___________day_____/_______at 1:30 -2:30 pm

you need to call the laboratory. Telephone number: 35454071, press 5 and then press 2.

The laboratory technologist will tell you about the result of the fertilization, development and how many blastocysts they were able to freeze.

In 20% of the treatments no blastocysts are developed enough to be able to make a trophectoderm biopsy.

What are the steps in the laboratory, what happens to the eggs?

Day 0

 

Day 1

Day 2

Day 3

 

Day 4

 

Day 5 and 6

Answer from the genetic analysis

When the analysis of the biopsy is ready the result will be sent to The Fertility Clinic. We will send it to you in e-boks. It takes approximately one month before you have the result. (A doctor from the Genetic ward may already have called you)

·         If there is a blastocyst with a quality to transfer, you need to contact us when you are ready (see below)

 

·         If there are no blastocysts with a quality to transfer, we kindly ask you to contact the secretary at the fertility clinic. You will get an appointment with a doctor from the PGT-team who will call you. You will discuss a plan for further treatments. If you would like to have an appointment in our Outpatient clinic you are welcome but expect some waiting time.

 

·         In few cases there are uncertainty about the result of the analysis. How this is handled will be written in the mail you receive in e-boks.

 

Good quality blastocysts will be frozen. Blastocysts with  uncertainty of the result will  be frozen and saved for later. Blastocysts that do not meet our criterias will be destroyed.

When you are ready to start a treatment

You can call the secretary at the fertility clinic when you start your menstruation (on cycle day 1) if you have a good quality blastocyst in the freezer.

The treatment can be done with two different protocols depending on your menstrual cycle.

It can be in your spontaneous cycle or with help from hormones (estradiol and progesterone).

If your menstruations cycle is more than 35 days you can use oral contraceptive pills after consultation with the doctor, while waiting for the next step.

 

The plan for you is:

 

____ You call us on your first day of menstrual bleeding and we will give you an appointment on your cycle-day 8 -12.

 

____ You call us on your first day of bleeding and after consultation start treatment with tablet Østradiol 2 mg (1 tablet) x 3 per day, from cycle-day 2. We will give you an appointment for an ultrasound examination after approximately  10 days of treatment with estradiol

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