Toppublikationer

Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement (American journal of human genetics)

Dapagliflozin, atrial fibrillation, and heart failure with mildly reduced or preserved ejection fraction in DELIVER (Journal of the American College of Cardiology)

Clinical features and prognostic factors in adults with brain abscess (Brain : a journal of neurology)

Device-related complications in the subcutaneous and transvenous ICD: a secondary analysis of the PRAETORIAN trial (European heart journal)

Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER (Nature medicine)

Targeting enkephalins and pituitary adenylate cyclase-activating polypeptide (PACAP) in migraine (Brain : a journal of neurology)

Efficacy and Safety of Dapagliflozin According to Frailty in Patients with Heart Failure: A Prespecified Analysis of the DELIVER Trial (Circulation)

Aptamer Proteomics for Biomarker Discovery in Heart Failure with Reduced Ejection Fraction (Circulation)

Oxygen Targets in Comatose Survivors of Cardiac Arrest (The New England journal of medicine)

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest (The New England journal of medicine)

Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation (European heart journal)

Observational and genetic studies of C-reactive protein levels and risk of Alzheimer's disease (Alzheimer's & dementia : the journal of the Alzheimer's Association)

Family History of Psychiatric Disorders as a Risk Factor for Maternal Postpartum Depression: A Systematic Review and Meta-analysis (JAMA psychiatry)

Iron Deficiency in Heart Failure and Effect of Dapagliflozin: Findings From DAPA-HF (Circulation)

Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A PALISI Network Document (American journal of respiratory and critical care medicine)

Plasma exchange in the intensive care unit: a narrative review (Intensive care medicine)

Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC (Circulation)

Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study (Brain : a journal of neurology)

Diverse mutational landscapes in human lymphocytes (Nature)

Remission and low disease activity (LDA) prevent damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort (Annals of the rheumatic diseases)

Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season (Nature medicine)

Pharmacogenetics-guided CETP inhibition: an open question? (European heart journal)

The biofilm life cycle: expanding the conceptual model of biofilm formation (Nature reviews. Microbiology)

Reply to 'Lactate as a major myokine and exerkine' (Nature reviews. Endocrinology)

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review (Journal of the American College of Cardiology)

Clinical research in ovarian cancer: consensus recommendations from the Gynecologic Cancer InterGroup (The Lancet. Oncology)

Brentuximab Vedotin Plus AVD for First-Line Treatment of Early-Stage Unfavorable Hodgkin Lymphoma (BREACH): A Multicenter, Open-Label, Randomized, Phase II Trial (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

The sequences of 150,119 genomes in the UK Biobank (Nature)

A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers (Science translational medicine)

Cerebrovascular Disease and Sleep-Disordered Breathing Need to Be Accounted for in Cognitive Impairment Following COVID-19-Reply (JAMA psychiatry)

Systemic or Vaginal Hormone Therapy After Early Breast Cancer: A Danish Observational Cohort Study (Journal of the National Cancer Institute)

Overall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin's Lymphoma (The New England journal of medicine)

Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis (BMJ (Clinical research ed.))

Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses (BMJ (Clinical research ed.))

Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3B, Randomized, Placebo-Controlled Study (American journal of respiratory and critical care medicine)

Long-Term Morbidity and Mortality in Children After In Utero Exposure to Maternal Cancer (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

Anticoagulants for thrombosis prophylaxis in acutely ill patients admitted to hospital: systematic review and network meta-analysis (BMJ (Clinical research ed.))

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial (Intensive care medicine)

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma (The Journal of clinical investigation)

Structural variations in cancer and the 3D genome (Nature reviews. Cancer)

Are there any reliable predictors of unreported alcohol consumption in MAFLD patients? (Journal of hepatology)

Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci (European heart journal)

Thrombopoietin receptor agonists in adult Evans syndrome: an international multicenter experience (Blood)

Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization (Nature reviews. Cardiology)

Safety and efficacy of eptinezumab for migraine prevention in patients with two-to-four previous preventive treatment failures (DELIVER): a multi-arm, randomised, double-blind, placebo-controlled, phase 3b trial (The Lancet. Neurology)

Restriction of Intravenous Fluid in ICU Patients with Septic Shock (The New England journal of medicine)

COVID-19 mRNA vaccination and myocarditis or pericarditis (Lancet (London, England))

Early Coronary Atherosclerosis in Women With Previous Preeclampsia (Journal of the American College of Cardiology)

A double negative: culture-negative infective endocarditis (European heart journal)

Ethical and organizational considerations: the next step in the implementation of volunteer responder programmes (European heart journal)

Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study (European urology)

Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations (Leukemia)

Minimal residual disease-guided stop and start of venetoclax plus ibrutinib for patients with relapsed or refractory chronic lymphocytic leukaemia (HOVON141/VISION): primary analysis of an open-label, randomised, phase 2 trial (The Lancet. Oncology)

Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study (Brain : a journal of neurology)

Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials (Intensive care medicine)

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19 (Nature immunology)

MRI lesions of the spine in patients with axial spondyloarthritis: an update of lesion definitions and validation by the ASAS MRI working group (Annals of the rheumatic diseases)

Microdissection Testicular Sperm Extraction Versus Multiple Needle-pass Percutaneous Testicular Sperm Aspiration in Men with Nonobstructive Azoospermia: A Randomized Clinical Trial (European urology)

Reply to "Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk" (Alzheimer's & dementia : the journal of the Alzheimer's Association)

Patients with CLL have a lower risk of death from COVID-19 in the Omicron era (Blood)

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline (Intensive care medicine)

Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21^R110 (Leukemia)

Evaluating Primary Endpoints for COVID-19 Therapeutic Trials to Assess Recovery (American journal of respiratory and critical care medicine)

Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial (JAMA)

Improving the design of RCTs in non-radiographic axial spondyloarthritis (Nature reviews. Rheumatology)

Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial (Leukemia)

Children with autoimmune liver disease have limited access to age-appropriate drug formulations, results from a European survey (Journal of hepatology)

The European Heart Journal: fulfilling the mission (European heart journal)

ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance (Acta neuropathologica)

Intervening on the storage time of RBC units and its effects on adverse recipient outcomes using real-world data (Blood)

Randomized Phase II Study of Nivolumab With or Without Ipilimumab Combined With Stereotactic Body Radiotherapy for Refractory Metastatic Pancreatic Cancer (CheckPAC) (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility (Nature genetics)

School performance in Danish children exposed to maternal type 1 diabetes in utero: A nationwide retrospective cohort study (PLoS medicine)

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset (Annals of the rheumatic diseases)

Risk of hospitalisation associated with infection with SARS-CoV-2 omicron variant versus delta variant in Denmark: an observational cohort study (The Lancet. Infectious diseases)

Efficacy and Safety of Dapagliflozin According to Frailty in Heart Failure With Reduced Ejection Fraction : A Post Hoc Analysis of the DAPA-HF Trial (Annals of internal medicine)

Accelerated and personalized therapy for heart failure with reduced ejection fraction (European heart journal)

Prenatal and postnatal exposures to endocrine disrupting chemicals and timing of pubertal onset in girls and boys: a systematic review and meta-analysis (Human reproduction update)

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic (The Journal of experimental medicine)

Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF (Circulation)

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia (Intensive care medicine)

Heart transplantation: focus on donor recovery strategies, left ventricular assist devices, and novel therapies (European heart journal)

Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation (Annals of internal medicine)

Mitapivat versus Placebo for Pyruvate Kinase Deficiency (The New England journal of medicine)

Risk of adverse events after covid-19 in Danish children and adolescents and effectiveness of BNT162b2 in adolescents: cohort study (BMJ (Clinical research ed.))

Internal Mammary Node Irradiation in Patients With Node-Positive Early Breast Cancer: Fifteen-Year Results From the Danish Breast Cancer Group Internal Mammary Node Study (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

New insights into the genetic etiology of Alzheimer's disease and related dementias (Nature genetics)

Effect of Alirocumab Added to High-Intensity Statin Therapy on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction: The PACMAN-AMI Randomized Clinical Trial (JAMA)

Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia (Intensive care medicine)

Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure (Circulation)

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study (Annals of internal medicine)

Longitudinal analysis of ANA in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort (Annals of the rheumatic diseases)

Neuropsychiatric and Cognitive Outcomes in Patients 6 Months After COVID-19 Requiring Hospitalization Compared With Matched Control Patients Hospitalized for Non-COVID-19 Illness (JAMA psychiatry)

Exerkines in health, resilience and disease (Nature reviews. Endocrinology)