Safety and efficacy of the epithelial sodium channel blocker idrevloride in people with primary ciliary dyskinesia (CLEAN-PCD): a multinational, phase 2, randomised, double-blind, placebo-controlled crossover trial (The Lancet. Respiratory medicine)

Risk of cancer and mortality in Peutz-Jeghers syndrome and Juvenile Polyposis Syndrome - a nationwide cohort study with matched controls (Gastroenterology)

Outcomes Associated With Intracranial Aneurysm Treatments Reported as Safe, Effective, or Durable: A Systematic Review and Meta-Analysis (JAMA network open)

Tisotumab Vedotin in Combination With Carboplatin, Pembrolizumab, or Bevacizumab in Recurrent or Metastatic Cervical Cancer: Results From the innovaTV 205/GOG-3024/ENGOT-cx8 Study (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

Back to basics for out-of-hospital cardiac arrest (Lancet (London, England))

The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action (Lancet (London, England))

Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma (The New England journal of medicine)

PD-1 and PD-L1 Blockade plus Chemotherapy in Endometrial Cancer. Reply (The New England journal of medicine)

Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea (American journal of hematology)

Atypical fibroxanthoma and pleomorphic dermal sarcoma: Local recurrence and metastasis in a nationwide population-based cohort of 1118 patients (Journal of the American Academy of Dermatology)

OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions (The New England journal of medicine)

Long-term Incidence of Ischemic Stroke Following Transient Ischemic Attack: A Nationwide Study During 2014-2020 (Circulation)

Severe asthma trajectories in adults: findings from the NORDSTAR cohort (The European respiratory journal)

Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events (JAMA)

Long-term follow up of patients with WHO grade 2 oligodendroglioma (Journal of neuro-oncology)

Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial (Circulation)

Neratinib + fulvestrant + trastuzumab for HR-positive, HER2-negative, HER2-mutant metastatic breast cancer: outcomes and biomarker analysis from the SUMMIT trial (Annals of oncology : official journal of the European Society for Medical Oncology)

Genome sequencing for the fast diagnosis of early-onset epilepsies (The Lancet. Neurology)

MOLNUPIRAVIR COMPARED TO NIRMATRELVIR/RITONAVIR FOR COVID-19 IN HIGH-RISK PATIENTS WITH HAEMATOLOGICAL MALIGNANCY IN EUROPE. A MATCHED-PAIRED ANALYSIS FROM THE EPICOVIDEHA REGISTRY (International journal of antimicrobial agents)

Molecular Results and Potential Biomarkers Identified from the Phase 3 MILO/ENGOT-ov11 Study of Binimetinib vs Physician Choice of Chemotherapy in Recurrent Low-Grade Serous Ovarian Cancer (Clinical cancer research : an official journal of the American Association for Cancer Research)

European candidaemia is characterised by notable differential epidemiology and susceptibility pattern: Results from the ECMM Candida III study (The Journal of infection)

Leisure-Time Physical Activity and Risk of Microvascular Complications in Individuals With Type 2 Diabetes: A UK Biobank Study (Diabetes care)

Second messenger signaling bypasses CGRP receptor blockade to provoke migraine attacks in humans (Brain : a journal of neurology)

Inhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut-liver-brain axis: an experimental and bioinformatic study (Cell death & disease)

Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial (Lancet (London, England))

Atogepant, the first oral preventive treatment for chronic migraine (Lancet (London, England))

Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis (Journal of autoimmunity)

Outcome for Children and Young Adults With T-Cell ALL and Induction Failure in Contemporary Trials (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

The short-term and long-term adverse effects of melatonin treatment in children and adolescents: a systematic review and GRADE assessment (EClinicalMedicine)

A Skin Care Program to Prevent Skin Problems due to Diabetes Devices in Children and Adolescents: A Cluster-Controlled Intervention Study (Diabetes care)

Liquid biopsies with circulating plasma HPV-DNA measurements - a clinically applicable surveillance tool for HPV-positive oropharyngeal cancer patients (Clinical cancer research : an official journal of the American Association for Cancer Research)

Patient characteristics, microbiology, and mortality of infective endocarditis after transcatheter aortic valve implantation (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease (Genome medicine)

Risk of Depression in People With HIV: A nationwide population-based matched cohort study (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

The molecular aspect of anti-glaucomatous eye drops - are we harming our patients? (Molecular aspects of medicine)

Association between severe non-adherence to hydroxychloroquine and SLE flares, damage, and mortality in 660 patients from the SLICC Inception Cohort (Arthritis & rheumatology (Hoboken, N.J.))

Use of melatonin in children and adolescents with idiopathic chronic insomnia: a systematic review, meta-analysis, and clinical recommendation (EClinicalMedicine)

Use of melatonin for children and adolescents with chronic insomnia attributable to disorders beyond indication: a systematic review, meta-analysis and clinical recommendation (EClinicalMedicine)

Sickle cell disease landscape and challenges in the EU: the ERN-EuroBloodNet perspective (The Lancet. Haematology)

Out-of-Hospital Cardiac Arrest in individuals with Human Immunodeficiency Virus infection - A nationwide population-based cohort study (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

The 5-HT_1F receptor as the target of ditans in migraine - from bench to bedside (Nature reviews. Neurology)

Is combined exercise and incretin-based therapy the way forward for weight-loss maintenance? (Nature reviews. Endocrinology)

Novel precision medicine approaches and treatment strategies in hematological malignancies (Journal of internal medicine)

Physiological role of cytokines in the regulation of mammalian metabolism (Trends in immunology)

Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial (Annals of the rheumatic diseases)

Outcomes following SARS-CoV-2 infection in individuals with and without inflammatory rheumatic diseases: a Danish nationwide cohort study (Annals of the rheumatic diseases)

Data-driven care for patients with neurodegenerative disorders (Nature reviews. Neurology)

Omicron variant-specific serological imprinting following BA.1 or BA.4/5 bivalent vaccination and previous SARS-CoV-2 infection: A cohort study (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

Imprinting disorders (Nature reviews. Disease primers)

SURMOUNT-2: new advances for treating obese type 2 diabetes with tirzepatide (Lancet (London, England))

Microorganisms that commonly cause infective endocarditis- what about Aerococcus in the Duke-ISCVID criteria? (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

Giant Cell Arteritis Confirmed by 2-[¹⁸F]FDG PET/CT, Missed on Biopsy (Ophthalmology)

Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study (Clinical cancer research : an official journal of the American Association for Cancer Research)

Final analysis of the CLL2-GIVe trial (obinutuzumab, ibrutinib, and venetoclax) in untreated CLL with del(17p)/TP53mut (Blood)

Global treatment outcomes of extensively drug-resistant tuberculosis in adults: A systematic review and meta-analysis (The Journal of infection)

Mental disorders, participation, and trajectories in the Danish colorectal cancer programme: a population-based cohort study (The lancet. Psychiatry)

Effect of a Nurse Navigation Intervention on Mental Symptoms in Patients With Psychological Vulnerability and Breast Cancer: The REBECCA Randomized Clinical Trial (JAMA network open)

Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial (The Lancet. Respiratory medicine)

Putting data to work for precision medicine (Cell reports. Medicine)

Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots (Nature metabolism)

Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis (Human reproduction update)

Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock (Intensive care medicine)

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies (Intensive care medicine)

Rituximab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis (JAMA neurology)

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake (Nature genetics)

European Respiratory Society clinical practice guideline: palliative care for people with COPD or interstitial lung disease (The European respiratory journal)

Management of type 1 diabetes in pregnancy: update on lifestyle, pharmacological treatment, and novel technologies for achieving glycaemic targets (The lancet. Diabetes & endocrinology)

Impact of Minimal Residual Disease on Progression-Free Survival Outcomes After Fixed-Duration Ibrutinib-Venetoclax Versus Chlorambucil-Obinutuzumab in the GLOW Study (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)

Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results (Nature medicine)

Rucaparib for the Treatment of Metastatic Castration-resistant Prostate Cancer Associated with a DNA Damage Repair Gene Alteration: Final Results from the Phase 2 TRITON2 Study (European urology)

Web Exclusive. Annals On Call - Subclinical Coronary Atherosclerosis (Annals of internal medicine)

Sequencing Identifies Novel Genetic Variants Associated with High-risk Testicular Cancer (European urology)

Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research (Alzheimer's & dementia : the journal of the Alzheimer's Association)

Patients Hospitalized With Coronavirus Disease 2019: A Diverse Population (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study (The Lancet. Infectious diseases)

Characterisation of carbapenemase-producing Acinetobacter baumannii isolates from danish patients 2014-2021: detection of a new international clone - IC11 (International journal of antimicrobial agents)

Point-of-care urine LAM testing to guide tuberculosis treatment among severely ill in-patients with HIV in real-world practice: a multi-center stepped wedge cluster-randomized trial from Ghana (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry (Circulation)

RNA analysis of tape strips to rule out melanoma in lesions clinically assessed as cutaneous malignant melanoma: A diagnostic study (Journal of the American Academy of Dermatology)

COVID-19 and Risk for Mental Disorders Among Adults in Denmark (JAMA psychiatry)

Is the Biphasic Effect of Diabetes and Obesity on Fetal Growth a Risk Factor for Childhood Obesity? (Diabetes care)

Impact of type 2 diabetes on mortality, cause of death, and treatment in chronic lymphocytic leukemia (American journal of hematology)

Cancer in Patients With Familial Adenomatous Polyposis: A Nationwide Danish Cohort Study With Matched Controls (Gastroenterology)

Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins (JAMA surgery)

Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease (JAMA network open)

Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria (JAMA network open)

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database (EClinicalMedicine)

Evaluation of four laboratory-based high-throughput SARS-CoV-2 automated antigen tests compared to RT-PCR on nasal and oropharyngeal samples (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)

High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations (Blood)

Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature genetics)

First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia (The New England journal of medicine)

A first-in-human study of the fibroblast activation protein-targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors (Science translational medicine)

A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories (Nature medicine)

COVID-19 mortality among selective serotonin reuptake inhibitor users-results from a nationwide cohort (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)

A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids (Developmental cell)

Aquaporin-4 and GPRC5B: old and new players in controlling brain oedema (Brain : a journal of neurology)

Immediate COVID-19 treatment in CLL (Blood)

The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)

Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial (Nature metabolism)

Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial (Annals of oncology : official journal of the European Society for Medical Oncology)