Transcriptomic Differences between the Cephalic and Extra-cephalic Pain Pathways in Rat (2019)

Abstract

Migraine is the most prevalent neurological disease worldwide and is only surpassed by lower back pain as the disease with most years lived with the disability. Despite 30 years of progress in migraine research the pathophysiology behind a migraine attack and the origin of the pain is still largely unknown. A significant
amount of knowledge was generated with the so-called migraine provocation studies, where infusion of certain drugs induced headache during infusion and a delayed migraine attack in migraineurs, but no pain in the rest of the body. Thus, there must be differences in signalling mechanisms and/or pain transmission in the cephalic pain system compared to the extra-cephalic pain system. In 2016, 44 SNPs in 38 loci were identified as increasing the risk of migraine in 375,000 people from across Europe. These results showed that a significant number of these SNPs are located outside the coding regions, primarily in regions involved in regulation of gene expression. Thus, rather than giving rise to functional mutations, these SNPs confer differences in gene expression.
The aims of this project were first to investigate transcriptomic differences in naïve rats between the cephalic pain system, in this case consisting of the trigeminal ganglia and the.... 

Place of employment

PhD author

Rikke Elgaard Christensen, Cand.Scient.

Date and place of defense

5th December 2019, Department of Neurology, Danish Headache Center

Supervisors

Supervisor: Prof. Dr. Jes Olesen.
Supervisor: DMSc Inger Jansen-Olesen.

Links

PubMed
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