Fluid-based biomarkers to assess the effect of physical exercise in Alzheimer's disease; The ADEX trial (2019)

Abstract

In an effort to arrest the decline in cognitive function and loss of Activities of Daily Living, we have in this study investigated a non-pharmacological approaches. In this randomized clinical trial 'Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study' we analyzed the effect of 16 weeks moderate-to-high intensity physical organized and monitored exercise in patients with Alzheimer's Disease (AD) on a cognitive, functional, and molecular level. The central hypothesis of the ADEX study was that patients with mild AD would benefit on cognition, physical function and executive function.

Here investigated the underlying molecular changes in four different studies focusing on the 1) molecular patholgy know in AD, 2) The ablilty to maitain neuronal stablity, 3) The effect of exercise on neuroinflammation, and lastly 4) a post-hoc analysis of the add-on effect of the genetic risk facot APOE e4 and exercise.

Place of employment

PhD author

Camilla Steen Jensen, cand.scient.

Date and place of defense

2nd of July 2019, The Memory Clinic, Copenhagen University Hospital Rigshospitalet

Supervisors

Professor Steen Gregers Hasselbalch, MDSc
Anja Hviid SImosne, PhD
External PhD assessor Professor Bente Finsen MDSC, PhD from Department of Clinical Research, University of Southern Denmark

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