Through four papers the project investigated potential overdiagnosis and overtreatment in Danish children below five years of age using register data 1994-2016.
Paper I described temporal trends in mortality and health service utilisation in Danish under-fives. Post-discharge mortality was defined as mortality in the period after the first discharge from the hospital to the home after birth. Health services included hospital and general practice contacts as well as medication use. Children with severe chronic disease were identified using an algorithm capturing relevant ICD-10 codes. Paper II analysed risk factors of post-discharge under-five mortality in the general child population and in healthy children without severe chronic disease. Paper III defined the linear predictor from paper II as a mortality risk score. To study the match between the need and use of health services, the score was compared to the recurrence of health services. Childhood vaccination was analysed as an additional outcome. Further, local differences in the match between need and use of health services were explored across the 98 Danish municipalities. Paper IV analysed non-specific mortality and morbidity effects of childhood vaccinations to explore the hypothesis that the DTP and MMR vaccines are associated with detrimental respectively beneficial effects.
Place of employment
Department of Paediatrics and Adolescent Medicine
Date and place of defense
5th March 2020, Department of Clinical Microbiology, Rigshospitalet
Gorm Greisen (main)
Per Kragh Andersen
John Sahl Andersen
Lone Graff Stensballe