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The Stroke Research Group

​The stroke research group at the Department of Neurology, Rigshospitalet, undertakes clinical research on the entire stroke   spectrum from epidemiology, prevention, acute treatment, mechanisms, diagnostic examinations,  neurorehabilitation and organization. 


​Our research group is physically located at Rigshospitalet, Copenhagen Center, and Clinical Stroke Research Unit, Rigshospitalet, Glostrup, and we participate in relevant projects across the sites. 

Main research areas 

Epidemiology and primary prevention of stroke

Our research group has national and international collaboration with other research groups on stroke risk factors and stroke occurrence (stroke epidemiology). The access to the Danish Stroke Registry and other national databases is unique and provides an opportunity for detailed analyses of a large stroke population, co-morbidities, pharmacologic treatment, and long-term outcome after stroke.  

Stroke in the acute phase -neuroimaging and treatment 

We are participating in developing improved stroke scanning protocols including the use of artificial intelligence.  
Acute treatment of stroke includes intra-venous alteplase, endovascular mechanical removal of vessel occlusions, acute management of blood-pressure, screening for coagulation disorders and cardiac sources of embolism, cervical artery disease such as atherosclerosis and dissection, etc. We have large well-established databases enabling detailed studies of factors associated with outcome after endovascular treatment in patients with ischemic stroke and large vessel occlusion, and causes and outcome after stroke in children. 
In studies of mechanisms in the acute phase we focus on biomarkers, near infrared spectroscopy during revascularization in large vessel stroke stroke, pathophysiology, classification and sleep disturbances. 

Neurorehabilitation

Our group is pioneering the research on impact of naturalistic lightning in stroke patients admitted to in-hospital neuro-rehabilitation.  
In studies of mechanisms in the rehabilitation phase, we are involved in PET-scanning stroke patients to demonstrate the post-stroke neuroplasticity.

Patient and relatives involvement

We work on a personalized information system, and optimal ways to communicate with aphasic and cognitively impaired stroke patients and by a new PRO instrument, for use prior to out-patient follow-up.

Clinical trials

We participate in industry- and investigator-driven national and international clinical drug and device phase II and III trials and observational studies.

Group leaders and post doc.'s

  • Group Leader, Rigshospitalet, Glostrup: Helle Klingenberg Iversen, DMSci, associate professor Helle.Klingenberg.Iversen@regionh.dk
  • Group Leader, Rigshospitalet, Copenhagen Center: Thomas Truelsen, PhD, DMSci, associate professor Thomas.Clement.Truelsen@regionh.dk)
  • Post doc. Anders Sode West, PhD: The impact of naturalistic lightning 
    Anders.sode.west@regionh
  • Post doc. Mia Ingerslev Loft, PhD, MScN, Clinical Nursing Specialist , Head of Nursing Research, Department of Neurology, Rigshospitalet, Assistant Professor, Department of Public Health, Aarhus University Belle.mia.ingerslev.loft@regionh.dk

Key collaborators 

  • ​Rigshospitalet:Department of Neuroradiology, Neuro-interventional team, Danish Center for Sleep medicine.  Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine, and PET,  Department of Bio-chemistry, Department of Neuro-pediatrics and Neurobiology Research Unit. Klaus Hansen, Team Leader, endovascular therapy
  • ​Other: The Global Burden of Disease group, Seattle, WA, USA, Martin J O’Donnell, PhD, Population Health Research Institute, McMaster University, Hamilton, ON, Canada, Søren Paaske Johnsen, PhD,  professor, Danish Center for Clinical Health Services Research, Department of Clinical Medicine, Aalborg University. Marie Louise Nørredam, PhD, Professor, Danish Research Center for Migration, Ethnicity and Health, Department of Public Health, University of Copenhagen Faculty of Health and Medical Sciences.
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