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Copenhagen Neuroanaesthesiology and Neurointensive Care Research Group

Copenhagen Neuroanaesthesiology and Neurointensive Care Research Group​ focus on anaesthesia and perioperative management for neurosurgery, interventional neuroradiology, and magnetic resonance imaging; intensive care for severe acute brain and spinal cord injury; multimodal neuromonitoring and human-experimental models.​


Main medical speciality: Neuroanaesthesiology

​Our research aims to improve patient treatment. We focus on anaesthesia and perioperative management for neurosurgery, interventional neuroradiology, and magnetic resonance imaging; intensive care for severe acute brain and spinal cord injury; multimodal neuromonitoring and human-experimental models.

Main research areas

  • Randomised clinical trials to improve care in patients with severe acute brain and spinal cord injury. Current trials concern ketamine sedation to treat cortical spreading depolarisations (KETA-BID), blood transfusion targets (TRAIN), and regimens for external ventricular drainage cessation (DRAIN).
  • Pathophysiology of acute brain and spinal cord injury. Emphasis on cerebral autoregulation disturbances, cortical spreading depolarisations, and systemic and cerebral glucose metabolism and nitrosative/oxidative stress. Our group takes an interest in advanced multimodal neuromonitoring both as a research tool and as a clinical monitoring modality. 
  • Physical therapy, rehabilitation, and consequences of critical illness including delirium, early mobilisation, dysphagia, and long-term cognitive impairment.
  • Cerebral effects of general anaesthesia with emphasis on neuroplastic changes induced by general anaesthesia in healthy volunteers.
  • Perioperative management in neurosurgical patients focusing on brain tumour surgery.

Current team members 

Senior researchers

  • Martin Kryspin Sørensen
  • Nicolai Lohse
  • Søren Bache

Postdoctoral researchers

  • Laura Krone Larsen
  • Christian Gunge Riberholt (​Department of Neurorehabilitation / Traumatic Brain Injury, Hvidovre Hospital)

PhD students

Markus Harboe Olsen, Alexandra Vassilieva, Anton Lund, Trine Hjorslev Andreasen (Department of Neurosurgery), Anne-Sophie Worm Fenger, Signe Janum Eskildsen (Department of Occupational Therapy and Physiotherapy), Tenna Capion (Department of Neurosurgery), Sarah Pedersen (Department of Neurosurgery), Signe Sloth Madsen and Elisabeth Kjær Jensen (both affiliated with the Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup)

Research nurses

  • Helene Ravnholt Jensen (coordinator)
  • Ida Møller Larsen
  • Søren Røddik Ebdrup
  • Marie Baltser Jacobsen
  • Nils Lars Mikael Hedlund

Master students

  • Isabella Ankerstjerne Carvalho
  • Frederik Madsen
  • Nohad El-Manzalawy
  • Anna Forsberg

Key collaborators

  • Tiit Mathiesen, Department of Neurosurgery, Rigshospitalet
  • Marianne Juhler, Department of Neurosurgery, Rigshospitalet
  • Jane Skjøth-Rasmussen, Department of Neurosurgery, Rigshospitalet
  • Daniel Kondziella, Department of Neurology, Rigshospitalet
  • Martin Fabricius, Department of Clinical Neurophysiology, Rigshospitalet
  • Gitte Moos Knudsen, The Neurobiology Research Unit, Rigshospitalet
  • Ronan Berg, Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet
  • Christian Gluud, Copenhagen Trial Unit, Rigshospitalet
  • Bente Klarlund Pedersen, Centre for Physical Activity Research, Rigshospitalet
  • Mads Werner, Multidisciplinary Pain Centre, Rigshospitalet Glostrup
  • Signe Tellerup Nielsen, Department of Anaesthesiology, Bispebjerg Hospital
  • Rikke Krogh-Madsen, Department of Infectious Disease, Amager & Hvidovre Hospital
  • Damian M. Bailey, The Neurovascular Research Laboratory, University of South Wales, UK



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