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Danish Center for Human Reproductive Epidemiologi (DACHRE)

Research group established in 2006. Focus areas: Human reproduction, pharmacoepidemiology, early pregnancy complications, induced abortion, ectopic pregnancies, gynaecological endocrinology, endometriosis and polycystic ovary syndrome.

​​​​Main medical specialty: Obstetrics and Gynaecology

​Main research areas​

​​Reproductive epidemiology
  • ​Fecundity over time
  • Pregnancy loss
  • Pregnancy loss and long-term morbidity and mortality​
  • Ectopic pregnancies
  • Long-term prognosis in women after a first ectopic pregnancy
  • Risk of ectopic pregnancies – intergenerational study
  • Induced abortion and mental health
  • Contraception​
National Quality Database in early pregnancy complications

​(TiGrAb). Established in 2006

Pharmacoepidemiology:
  •  Hormonal contraception and venous thrombosis
  •  Hormonal contraception and arterial thrombosis (stroke, AMI)
  •  Hormonal contraception and female cancers
  •  Hormonal contraception and mental disease
  •  Hormone therapy and cardiovascular diseases
  •  Hormone therapy and female cancers
  •  Cyproterone acetate exposure and risk of meningioma

Gynaecological endocrinology

  • Hormonal contraceptive use
  • Polycystic ovary syndrome
  • Endometriosis
  • ​Hormone therapy
Obstetrics
  •  Post-term deliveries and induction practice by time
  •  Stillbirth 
  •  Birth induction and stillbirth
  •  Perinatal morbidity
  •  Pregnancy & delivery complications in women with endometriosis
  •  Venous thrombosis in pregnancy – risk factors
  •  Prenatal diagnosis
  •  Cancer in pregnancy
  •  Covid-19 infection in pregnancy and maternal and fetal outcomes
Infertility  
  •  Imprinting disorders in children conceived by ART
  •  Short- and long-term morbidity in children conceived by ART 
Gender incongruence
  • Descriptive epidemiology in incidence by time
  • Gender incongruence and cardiovascular diseases
  • Gender incongruence and long-term morbidity
Sexual assault
  • Physical and psychical morbidity before and after an assault
Climate change and health
  • Paleoclimate history and future perspectives

Current team members ​

Reproductive epidemiology
  • Anders P. Mikkelsen, MD, PhD 
  • Steen Rasmussen, datamanager
National Quality Database in early pregnancy (TiGrAb)  
  • Øjvind Lidegaard. Head of database.  
  • Amani Meaidi, MD, PhD, post doc.  
  • Pernille Ravn, MD, PhD, professor, Odense University Hospital
Pharmacoepidemiology
  • Vibe Gedso Frøkjaer, PhD, Neurobiology Research Unit, RH 
  • Søren Vinther Larsen, MD, PhD student, Neurobiology, RH
  • Therese Johansson, PhD student, Uppsala University Hospital.
  • Philip Hannaford, MD, professor, Aberdeen, Scotland
  • Lisa Iversen, PhD, epidemiologist, Aberdeen, Scotland
  • Shona Fielding, PhD, statistician, Aberdeen, Scotland 
Gynaecological endocrinology
  • Dorthe Hartwell, MD, Head of endometriosis team
  • Pernille Ravn, PhD, professor, Odense University Hospital 
Obstetrics
  • Olav Bjørn Petersen, MD, PhD, professor, Fetal Medicine, RH
  • Lone Storgaard, MD, PhD, Consultant, Dept. of Obstetrics, RH
  • Charlotte Ekelund, MD, PhD, Fetal Medicine, Rigshospitalet 
Infertility
  • Anja Pinborg, MD, PhD, professor, fertility clinic, RH
  • Anne Vejen Hansen, MD, PhD student
  • Anna Karina Aaris, MD, PhD student, Hillerød Univ. Hospital
Gender incongruence
  • Malene Hilden, PhD, Head Center for Gender Incongruence, RH
  • Mie-Louise Ørsted Larsen, PhD, dept. Of Gynaecology, RH
Sexual assault
  • Malene Hilden, PhD, Head Center for Gender Incongruence, RH
  • Mie-Louise Ørsted Larsen, PhD, dept. Of Gynaecology, RH​
Epidemiological research methods
  • Ulrik Kesmodel, MD, PhD, professor, Aalborg University Hospital
  • Linn Arendt, MD, PhD, Horsens University Hospital. 
Climate change and health 
  • Øjvind Lidegaard, MD, DMSci, professor, dept. Gynaecology, RH​​

Key collaborators​

Danish collaborators
  • Neurobiological Research Unit RH, 
  • Department of Obstetrics RH, 
  • Fertility Clinic, RH, 
  • Department of Gynaecology in Hvidovre, Herlev, Hillerød, Roskilde, Holbaek, Odense, Skejby, and Aalborg.
International collaborators
  • Tromsø University; professor Finn Egil Skjeldestad, 
  • Sahlgrenska University Hospital, Gothenburg; prof. Ian Milsom, 
  • Uppsala University Hospital; associate prof. Asa Jophansson
  • Karolinska University Hospital; prof. Kristina Gemzell Danielsson, Helsinki University Hospital; professor Oskari Heikenheimo 
  • Aberdeen University; professor Philip Hannaford, Lisa Iversen
  • Amsterdam UMC; Judith Dekker and professor Velja Mijatovic

Actual ongoing projects

Reproductive epidemiology
  • Therese Johansson; Effects of exogenous hormones on female health, PhD student. Uppsala University
​Obstetrics
  • Anders P. Mikkelsen at al. Maternal, obstetric and perinatal outcomes in women with Covid-19 infection in pregnancy. Anders P.Mikkelsen 
Pharmacoepidemiology
  • Hormone therapy and risk of breast cancer. Mikkelsen, Lidegaard, Løkkegaard.
  • Hormonal contraception and venous thrombosis. An update. Mikkelsen and Lidegaard
  • ​Post Authorization Safety Study on drospirenone only contraception. Collaboratory study with Helsinki University Hospital.
    Lidegaard, Mikkelsen, and Maarit Leinonen, MD, Adjunct Professor, Finnish Institute for Health and Welfare (THL)
Early pregnancy complications (Tigrab)
  • Regions’ Clinical Quality Devepopment Program (RKKP)

​Funding

  • ​Novo Nordisk Foundation
  • Lundbeck Foundation
  • Exeltis Pharma​


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