Research

​The Department of Neurophysiology cooperates with the Institute of Neuroscience and Pharmacology at the University of Copenhagen, where researchers are involved in studies  of regeneration and degeneration of peripheral nerve, motor control, spacticity, epilepsy and dystonia.​

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Apart from collaboration with the University of Copenhagen the department is also collaborating with Duke University (United States), the University of Würzburg (Germany) and the Institute of Neurology, University College, London, the UK. 

Current projects

Regeneration and degeneration of peripheral nerve

Recovery after peripheral nerve lesions is studied in patients with nerve disorders and physical injury and in experimental animals, to gain insight into which factors influence and may improve recovery. Experimental animals studies are carried out in hereditary neuropathies and degenerative disorders in transgenic mice.

Studies on motor control and spasticity 

are carried out to develop new methods to study conduction within the brain and spinal cord. These studies are helpful to understand how the central nervous system controls movements and how disorders in the brain and spinal cord influence and limit force and movement.

Epilepsy and EEG

The Department of Neurophysiology plays a central role in the presurgical workup of patients with medically refractory epilepsy. We perform EEG-recordings with intracranial depth electrodes and investigate the changes in single units as well as field potentials during cognitive tasks as well as during sleep and awake. These projects run in collaboration with prof.John Duncan, Univ. College London, UK, as well as researchers at the Panum Institute, Copenhagen.

In a recent pilot study we tested the acute impact of transcutaneous vagal nerve stimulation on the spike-firing rate of intracranial EEG in collaboration with prof. Bartolomei, Univ. Marseille, France

Electrical source imaging (ESI) is increasingly used in the presurgical evaluation and Rigshospitalet has been part in several projects testing feasibility and impact if this method including a recent PhD-thesis. Currently we participate in the Promaesis multicenter Study on automatized ESI in collaboration with prof.Beniczky, Danish Epilepsy Centre Dianalund and Epilog, Ghent, Belgium.

A Red Cap database has been developed for the epilepsy surgery patient group, and together with the other departments of the Neurocentre, research projects are performed with similar centers in the other Nordic Countries and with prof. Philippe Ryvlin at the University of Lausanne, Switzerland. 

A PhD project “CONNECT-ME” will start in early 2020 addressing awareness in apparently comatose patients in the Neuro-ICU using advanced EEG-analysis and stimulation paradigms in collaboration with prof.Sitt, Sorbonne University, Paris, France.

We collaborate with the Neurobiology Research Unit and the Memory Clinic, Rigshospitalet on quantitative EEG analysis in normal volunteers and early dementia.​

Dystonia and involuntary movements

are extremely important and very frequent. These disorders can be treated by injection of botulinium toxin which is a powerful toxic substance. In order to minimize dose and target injection appropriately, EMG is a very important tool. The use of these EMG examinations in various dystonic muscles is a major undertaking at the department.

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