Multiple sclerosis – basic and clinical research
Neuromuscular diseases – basic and clinical research
- Studies of normal aging in muscle
- Studies in mitochondrial disease
- Treatment and pathophysiological studies of patients’ muscle glycogenoses and defects of lipid metabolism
- Animal and human studies of regeneration of skeletal muscle
- Studies on the effect of physical training in neuromuscular conditions
The Danish Dementia Research Centre (DDRC), which the Memory Clinic is a part of, has a clinical research group and a proteomics and neurogenetic laboratory, and it coordinates the Danish Dementia Biobank. The research in memory disorders focuses on clinical and translational dementia research and comprises programmes in biomarker discovery, neuroimaging, neurogenetics, epidemiology, and intervention research. The Danish Alzheimer Intervention StudY (DAISY) is a major research programme on early social support and counselling for patients with Alzheimer’s Disease.
The Memory Clinic participates in international drug trials from phases I to IV. The DDRC is a member of the European Alzheimer’s Disease Consortium (EADC) and the NordForsk network, and it is a partner in several EU-supported research programmes, of which LADIS, EDAR and PredictAD are still running.
Visit www.videnscenterfordemens.dk for more information.
Epilepsia – mainly clinical research
- Epilepsy and pregnancy - teratogenic effects of antiepileptic drugs
- Status epilepticus – effects of treatment and continuous EEG monitoring
- Epilepsy and surgery – epidemiology and outcomes
- Epilepsy and depression – neurobiological aspects
- Epilepsy in Down Syndrome – prevalence and seizure classification
- Epilepsy and fertility – effects of antiepileptic drugs on semen quality
Endovascular treatment of acute stroke and sinus venous thrombosis.
Rigshospitalet’s Stroke Service is at the forefront in developing these treatments to minimize residual deficiencies after a stroke. In the stroke prevention arena, the department provides various novel cardiovascular interventions to enhance stroke prevention in complex situations. These services are provided in close collaboration with cardiology, neuroanethesia, neurosurgery and neuroradiology.
At the Neurobiology Research Unit (www.nru.dk), research focuses on three major areas; neuroimaging, data analysis and experimental research.
The main research focus of the neuroimaging group is functional imaging in human using SPECT (Single Photon Emission Computed Tomography), PET (Positron Emission Tomography), and MR (Magnetic Resonance). The research focuses on the neural bases of personality dimensions, cognitive functions, and psychiatric disorders with special emphasis on the serotonergic neurotransmitter system. The group has an extensive collaboration with the PET and Cyclotron Centre at Rigshospitalet, the Danish Research Centre for Magnetic Resonance at Hvidovre Hospital, as well as other national and international functional imaging groups and with industry.
The Department of Medical Chemistry at the University of Copenhagen participates in the research on new radioligands. Several of these activities are brought together in the Centre of Integrated Molecular Brain Imaging (www.cimbi.org).
The research focus of the data analysis group is development and optimization of data analysis methods for PET and SPECT images of the brain. The group is involved in several projects such as:
- Development of new reconstruction methods which allow inclusion of advanced scanning models
- Neuroinformatics, and meta analysis of functional studies downloaded from Entrez-PubMed
- Development of automatic methods for definitions of volumes of interest (VOI's)
- Optimization of the clinical use of the SPECT scanner.
The experimental research takes place at the Neurobiology Laboratory. Research uses different animal models, experimental and transgenic; cell cultures, organotypic and primary hippocampal cultures and different transfected cell lines; and human material to elucidate the role of the serotonergic system in neuropsychiatric and neurodegenerative diseases like depression and Alzheimer’s disease. Research also makes use of fluorescence immunohistochemistry, confocal microscopy, autoradiography, receptor binding studies, PCR, western blot and ELISA. Collaboration with national and international groups as well as with the industry has been established.
The aim of the Neurobiology Laboratory is to create a two-way bridge between basic experimental research and the clinical projects carried out at the NRU. Weekly meetings, translational PhD projects and close interaction between the research staff create a dynamic forum, where ideas that range from basic to clinical neuroscience are exchanged and discussed.
The Neurobiology Research Unit is the headquarters of the Center of Integrated Molecular Brain Imaging (www.cimbi.org).