Lisette Kogelman, Mona Ameri Chalmer, Isa Olofsson, Tanya Techlo, and Thomas Folkmann Hansen.

Family studies and twin studies show that the risk of migraine is 50% inheritance and 50% environment. The identification of genes involved in migraine may give clues to underlying pathophysiological mechanisms. It is equally important to identify the environmental factors which so far are largely unknown.

We continue our collection of highly phenotyped patients and controls and currently have more than 4.000 patients most of whom are whole genome sequenced. Half of them are members of extended families of which we have more than 200. We also use the Danish Blood Donor Study with its more than 100.000 phenotyped persons who have been genotyped. Currently, we look for genes with high impact in familial cases including those with familial hemiplegic migraine. We also work with multiomics (RNA, biochemistry and proteins) and we extract important information from the huge Blood Donor Study. In cluster headache high risk variants have been identified and epigenetics are studied in medication overuse headache.