Christina Kruuse, Julie Carøe Kristensen, Maria Schmidt Uldall, Lars Schack Kruse.
Pain signalling in humans involve second messenger signalling through second messengers; cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Studies in humans show that specific modulation of such cyclic nucleotide signalling induce headache, though the tissues in which the processes take place and the possible interaction between signalling pathways is not fully understood. We aim to localize and investigate the role of cyclic nucleotide signalling in tissue and cells relevant for the pain process. In collaboration with Department of Clinical Biochemistry Glostrup, Department of Neuroscience and Pharmacology and Functional Imaging Unit and Dept Clinical Physiology and Nuclear medicine we have found unique localisation and function of molecules, phosphodiesterases (PDE), responsible for modulation of cGMP and cAMP signalling in cerebral arteries and the brain.
Co-localisation of PDEs with other relevant pain cellular signalling molecules in vascular and neuronal cell systems.
Investigating potential new targets for treatment in the pain mechanism of headache and migraine related to cyclic nucleotide signalling.
Localisation and role of PDE in the choroid plexus, interaction with natriuretic peptides and regulation of cerebrospinal fluid production in relation to idiopathic intracranial hypertension.
Rigmor Jensen (Danish Headache Center), Marianne Juhler (Dept. Neurosurgery, Rigshospitalet), Henrik Larsson (Functional Imaging Unit, Department of Clinical Physiology); Morten Møller (Department of Neurobiology and Pharmacology, Panum Institute); Joe Beavo and Sergei Rybalkin (Dept Pharmacology, University of Washington, Seattle); Lars Edvinsson (Department of Experimental Clinical Research, Glostrup Hospital); Steen Gammeltoft (Dept. Clinical Biochemistry, Glostrup).