Thomas Folkmann Hansen, Jes Olesen, Lisette Kogelmann, Mona Ameri, Julie Ravn Hansen, Isa Olufson, Emil Lønstrup Øhrstrøm,
Family studies and twin studies show that the risk of migraine is 50% inheritance and 50% environment. The identification of genes involved in migraine may give clues to underlying pathophysiological mechanisms. It is equally important to identify the environmental factors, which so far are largely unknown.
One aim of our studies is to identify the genes involved in migraine with aura, familial hemiplegic migraine, and migraine without aura. To date we have collected detailed clinical information and blood from over 3000 migraine patients. Genome wide association typing (GWAS) and exome chipping have been performed. We have also studied 70 extended families mostly with migraine with typical aura and many have been whole genome sequenced.
Enviromenment has been studied in population studies led by Professor Rigmor Jensen and in twin studies led by Jes Olesen. Most recently RNA in blood from patients during migraine attack has been studied. The results are now being utilized in collaboration with the gene finding company DeCode in Iceland and as members of the International Headache Genetics Consortium. We also participate in the STEMBANCC consortium funded under the Innovative Medicines program of the EU and have skin biopsies, fibroblast cultures and pluripotent stem cells from many patiens.