Jes Olesen, Sarah Louise Tangsgaard Christensen, Inger Jansen-Olesen, Brian Skriver Nielsen, Charlotte Ernstsen, Rikke Holm Rasmussen, Song Guo, Bettina Magrethe Jensen.
Decades of human study have revealed a number of mechanisms of migraine that must be further dissected in animal experiments. Glostrup Research Institute, located on the grounds of the hospital offers excellent facilities for experimental animal research.
There are several aims of this research. One is to investigate the interrelation of signaling mechanisms that can cause migraine in human patients and to evaluate whether they induce migraine inside or outside of the blood-brain-barrier. Another aim is to dissect the mechanisms of migraine provocation using genetically modified mice and pharmacological tools. Thirdly, molecular biological studies try to identify the cellular mechanisms whereby offending molecules induce migraine. For this research we use a validated mouse model, a closed cranial window model in the rat and studies of isolated blood vessels as well as different types of cultured cells.
We currently study how CGRP mechanisms relate to other migraine provocating agents and sensitization using pituitary adenylate cyclase activating peptide (PACAP). Nitric oxide mechanisms of migraine and the importance of potassium channels are other important research fields.