Jes Olesen, Inger Jansen-Olesen, Gordon Munro, Sarah Louise Tangsgaard Christensen, Steffen Petersen, Rikke Dyhr Hansen, Sanne Bukh Gundager.
Decades of human study have revealed a number of mechanisms of migraine that must be further dissected in animal experiments. Glostrup Research Institute located on the grounds of the hospital offers excellent facilities for experimental animal research. There are two aims of this research. One is to develop rat models that can predict efficacy of anti-migraine drugs and therefore can be used by the pharma industry in their testing of new potential migraine drugs. The other purpose is to use the models to dissect the molecular mechanisms of migraine. We capitalise on the studies in humans demonstrating number of signally molecules that can cause migraine-like headache in humans and use the same compounds in rats.
In one line of study lead by Gordon Munro we explore the use of Nitroglycerine and other migraine provoking agents in rats. Gordon Munro and Steffen Petersen also study a very special strain of rats with increased sensitivity in the head compared to the paws. These so-called spontaneous allodynie rats are available for study only at Glostrup Research Park. Studies led by Inger Jansen-Olsen examine the expression of RNA in areas of the brain that are important for migraine pain. We already demonstrated different RNA expression in the brain stem receiving input from the head as compared to the spinal ganglia that receive input from the rest of the body. Currently we study this in more detail and also the effect of Nitroglycerine infusion. Finally Inger Jansen-Olesen leads studies into the molecular mechanisms of PACAP, a molecule known to induce migraine in migraine sufferers. She examines the mechanisms where by the substance degranulates mast cells, a possible mechanism of migraine headache.