Multivitamin use and risk of pre-eclampsia: A systematic review and meta-analysis

The review aims to evaluate the association between use of multivitamin and the risk of pre-eclampsia among pregnant women

Preeclampsia is a pregnancy complication, usually occurring after 20 weeks of pregnancy, marked by elevated blood pressure and signs of damage to another organ system such as proteinuria. In severe cases preeclampsia can be fatal to both the mother and the baby due to multiorgan failure.  

Preeclampsia is hypothesized to be a result of poor placentation due to impaired remodeling of the spiral arteries during the trophoblast invasion of the myometrium, leading to vascular endothelial dysfunction, placental hypoxia, and increased oxidative stress. Studies have shown significant relations between low serum levels of vitamins and antioxidants and preeclampsia and its complications, therefore antioxidant and multivitamin therapy has been suggested for prevention of preeclampsia. 

This review will evaluate the suggestion of multivitamin therapy for prevention of preeclampsia, and studies in which the effect of multivitamin use on preeclampsia in the population is examined will be included.



Responsible editor