A follow-up on the DAKL cohort, children with acute and chronic liver failure

​A follow-up on the DAKL cohort to assess the prognostic values of paraclinical tests and thereby find better diagnostic tools to better the prognosis.

A research project by Christina Louise Winther

​Acute and chronic liver failure in children and adolescents can be a life-threatening condition.

Rigshopitalet (RH) has the national treatment responsibility of liver failure and treats all children and adolescents with acute or severe chronic liver failure. Those children who survive acute liver failure have either regained their own liver function or had a liver transplantation. Similarly, children and adolescents with severe chronic liver failure get a new liver. The transplanted children and adolescents receive lifelong immunosuppression and are at risk of developing severe complications relating to transplantation.

Clinically, it is a major challenge to assess which children need a liver transplant in the acute phase to survive. This is due to lack of consensus of objective and prognostic measurements to assess the regeneration potential of a native liver. 

At RH, 180 children with acute or chronic liver failure are already included in the DAKL cohort. Every year 6-8 children are liver transplanted. 

We want to do a follow-up on these children and adolescents 3-7 years after inclusion in the DAKL project since most of the patients have chronic, slow progressing liver failure. To assess the prognostic value of the tests included in the project, long follow-up is essential. 

The aim is to optimize the treatment and prognosis for children and adolescents with acute and chronic liver failure through better diagnostic and prognostic tests. 

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