Research overview and current projects

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Research areas of the Department of Paediatrics and Adolescent Medicine include: 


Neuropaediatrics

  • Epilepsy: Controlled study of the effect of treatment with Diacomit and Ketocal (ketogenic diet).
  • Follow-up study of epilepsy-surgical treatment of Danish children. The SUDEP (sudden death in epilepsy) national incidence study.
  • Neuro-muscular diseases: genetic classification of congenital myopathy.

Chronic lung diseases in children and young people
DBLC and CF Centre Copenhagen

  • CF studies concerning biofilm such as pharmacokinetic studies concerning varying absorption of different antibiotics among different patients.
  • Early diagnosis of structural lung damage, focused on refined and standardised lung CT scans, as well as functional loss, using a promising and very sensitive lung function method called the Multiple Breath Washout.
  • PCD scintigraphic method and measurements of NO in the nose, as supplementary diagnostic tests, and mapping of underlying mutations for the PCD disease. Finally, several of the studies mentioned for CF also include PCD patients. 

Hepatology

  • Liver transplantation in childhood: complications, side effects of immune suppression, growth and development. (In corporation with the Transplantation Clinic Rigshospitalet)

  • Autoimmune hepatitis; outcome, growth and development and inflammation.

  • Paracetamol poisoning (acetaminophen poisoning) during childhood and adolescence, implication and outcome, a national database. (in corporation with the Pediatric department Hillerød hospital).

  • Liver disease in Cystic fibrosis, diagnosis and nutrition. (in corporation with the Danish Cystic Fibrosis Center Rigshospitalet).

  • Treatment of Pediatric acute liver failure with Plasmapheresis. (in corporation with the Nephrology Clinic Rigshospitalet).

  • Treatment of moderate malnutrition in children (in corporation with Institute of Nutrition, Sport and Exercise, University of Copenhagen).

Haematology and oncology

  • Aetiology of leukaemia in children 
  • Individualised treatment based on pharmacogenetics, pharma kinetics and monitoring of minimal residual pharma kinetics
  • Late complications of cancer treatment

The research and analysis repertoire in particular comprise

  • Analysis (LC-MS) for cytostatica and cytostatica metabolites in blood, urine and DNA
  • Purification and PCR amplification of mRNA and DNA
  • Genotyping (single nucleotide polymorphisms) by means of TaqMan and GeneChips
  • Cell sorting (FACS)
  • DNA index analyses

Infection paediatrics and international paediatrics

  • The infection paediatric research focuses on respiratory tract infections in children, infections in immune-supprimed and diseases in foreign adoptive children.
  • The department participates in planning research and development projects on child health in low-income countries, such as Vietnam, Tanzania, Zanzibar and Bisau.

Bone marrow transplants (the TXID function)

  • Immunology in allogenic stem-cell transplant.
  • Lung, liver, intestinal diseases in connection with allogenic stem-cell transplants.
  • Psycho-social conditions in connection with allogenic stem-cell transplants.
  • The impact of environmental toxins on children’s immune function.

Rheumatology

  • Joint Nordic research cooperation on JIA.
  • International research cooperation in the Pediatric Rheumatology International Trials Organisation (PRINTO).
  • Multinational research cooperation in New York about Systemic Lupus Erythematosous (SLE) derived from the child’s rheumatologic unit.
  • Research cooperation with children’s hospital in Ho Chi Minh concerning SLE derived from Rigshospitalet. The department is active in research in small, international expert work groups, such as JDM and uveit.

Further information
For further information about the research or research areas see the publications​ of the department or contact one of the res​earchers​.  



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