Stabilising cerebral oxygenation
SafeBoosC enrolled 166 preterm infants in eight European countries. Our primary objective was to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants in the first 72 hours of life through the application of NIRS and the implementation of a clinical treatment guideline.
Reducing brain injury
We hypothesised that cerebral monitoring readings outside the target range with NIRS coupled with a treatment guideline on responses to out of range values would reduce the burden of hypo- and hyperoxia, consequently reducing brain injury.
A randomised clinical trial
The trial randomised participants after receiving approval from the national competent authorities and regional ethics committees as well as parental informed consent. The trial was conducted in compliance with good clinical practices and external monitoring.
Dedicated oximeter
As part of the SafeBoosC-project a prototype cerebral oximeter dedicated for use in small, extremely preterm infants was developed and tested.
Funding
SafeBoosC-II was funded in Jan 2012 by The Danish Council for Strategic Research with 11.1 mio dkk.