Research overview and current projects

​​​Below you will find a list of current research projects i The Department of Neonatology.


ETTNO (Transfusion tresholds in infants <1000 g)

Extremely preterm infants were randomised to blood transfusion at a 'normal' level of haemoglobin concentration and a lower level.  The primary outcome is survival at 2 years of age without moderate-to-severe neurodevelopmental impairment. The trial is coordinated from Tübingen, Germany.

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Babylux (mobile optical neuromonitor)

The monitor will combine measurement of cerebral oxygenation and measurement of cerebral blood flow. The monitor is designed and built by 7 technical partners in Italy, Spain, and Germany, and will be tested in two hospitals in Denmark and Italy. The project is coordinated from Milan and financed by EU.

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Neomune (Early Milk and microbiota to improve later immunity)

This is an international research network coordinated from Copenhagen University and funded by Stategisk Forskningsråd. We take part in a trial of cow colostrum as a supplement to mothers milk in very preterm infants during the first 10 days of life.

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NORD trial

A multicenter randomised clinical trial testing drainage of pneumothorax by simple puncture and evacuation of air compared to the standard treatment which is placement of a drainage tube. The trial is coordinated from Dublin, Ireland.

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A randomised trial of medical treatment of persistent pulmonary hypertension.

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Testing the clinical benefit of cerebral oxymetry combined with a treatment guideline. We have conducted a pilot trial with 10 patients,  a randomized clinical trial with 166 extremely preterm infants in eight European countries funded by The Danish Counsil for Strategic Research​ and is planning a randomized clinical trial with 1600 infants in 17 European countries funded by EU. The project Is coordinated from Rigshospitalet.

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Probiotics and NEC

A comparison of the risk of necrotising enterocolitis and death in infants less than 30 weeks admitted two three-year periods – before and after the implementing routine use of probiotics.

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Protein in breast milk

Studying the effect  of the interval between pumping breast milk on protein content.

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Dopamine and brain autoregulation

The effect of dopamine on brain arteries is studied in preterm infants, in piglets, and in isolated piglet arteries.

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Prescription medicine for asthma  in individuals born preterm

A study involving 1.7 mio individuals age 2-30 years using the national birth registry and the national prescription registry.

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Reliability of cerebral oximetry

Comparing arterial and cerebral hypoxia during apnea using two different commercial devices in preterm infants.

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High frequency ventilation with sighs

A randomized clinical cross-over trial of high frequency ventilation with and without 'sighs'. The primary outcome is oxygen requirement.

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Support upon discharge

In this study, we investigate the need for and the effectiveness of a flexible multidisciplinary nurse-led service of support to families of infants born between 28 and 34 weeks of gestational age. Service of support comprises telephone and e-mail contact to the nurse, telephone or out-patient clinic contact with specialists from the multidisciplinary team, and on-line parent-to-parent network. Primary outcomes are parent sense of safety and satisfaction with the service, secondary outcomes are infant development.

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