Gynaecological cancer

The Department of Gynaecology is involved in several national and international gynaecological cancer studies ranging from classic open surgery to laparoscopic and robotic surgery. The total research area is very broad covering all types of gynaecological cancer and almost all disciplines from basic molecular cancer, epidemiology to clinical research (translational research).
 

Cancer Databases

The department is the heading the Danish Gynaecological Cancer Database which is a national multidisciplinary clinical database. As the maybe first in the world the Department of Gynaecology has developed a comprehensive nursing database connected to the clinical database. The clinical databases establish the fundament for traditional medical as well as nursing research. The databases establish the fundament of numerous Ph.D. and post doc studies.

The department has also developed the nationwide database in robotic surgery (Robobase). Robobase was launched in 2013.

Translational research 

One of the main focus areas is translational research. Translational research is the process of applying findings from laboratory research and preclinical studies to accepted new treatments. The prospective ongoing Pelvic Mass and ENDOMET studies establish the basis for several local, national and international translational studies. Several international high ranking laboratories specialized into basic science, biochemistry and molecular biochemistry participate in the Pelvic Mass end ENDOMET studies


Current projects on gynaecological cancer


​Ovarian cancer

  • The Pelvic Mass Study. The Pelvic Mass Study is an ongoing prospective collection of blood and tissues for the biobank together with an intensive recording in a database of clinical and epidemiological data. All patients admitted for surgery because of a tumor (mass) in the female pelvis are invited to participate.
  • The Malignant Ovarian Cancer study (MALOVA) and the MERMAID project. MALOVA is a nationwide case/control study in ovarian cancer connected to a biobank. MALOVA is together with the Pelvic Mass study parts of the MERMAID group(ww​w.mermaid.dk​). The MERMAID group involves and participates in almost all disciplines of the most high ranking international epidemiologic and translational gynaecological cancer research.
  • Type 1 and 2 ovarian cancer. Project Responsible: Kira Phram
  • Lymphadendectomy and correct staging of ovarian cancer in Denmark. Project Responsible: Olivia Svolgaard
  • HE4 as a new serologic marker in epithelial ovarian cancer. Project Responsible: Mona Aarenstrup Karlsen
  • Thromboelastografi (TEG) in ovarian cancer as a preoperative marker for complications, prognosis and differentiating between benign and malignant pelvic masses. Project Responsible: Fanny Håkanson
  • MicroRNA as an ovarian cancer markerProject Responsible: Camilla Mandrup
  • Comorbidity is an independent prognostic factor for the survival of ovarian cancer: a Danish register-based cohort study from a clinical database. Project responsible: Cecilie Sperling
  • The influence of comorbidity in gynaecologic cancer with focus onovarian cancer. Project Responsible: Cecilie Sperling
  • Post Doc study: Clinical, epidemiological and molecular characteristics of gynaecologic clear cell carcinomas.Project Responsible: Tine Henrichsen Schnack
  • Borderline tumors in Denmark ad description of registration and prognosis. Project Responsible: Hellen Edwards

Corpus Cancer

  • ​​Comorbidity is an independent prognostic factor in uterine corpus cancer A nationwide cohort study based on data from a clinical databasee. Project responsible: Mette Calundann Noer
  • Endomet-study: The Danish endometrial cancer study (ENDOMET). Is a prospective collection of paired imaging data (PET/CT, MR and ultrasound), blood and tissue for biobanking and a comprehensive recording in a clinical database of clinical data.
  • Endometrial cancer survival in Denmark 2005-2011. Project Responsible: Claus Hoegdall
  • The influence of comorbidity in gynaecologic cancer with focus on endometrial cancer. Project Responsible: Mette Calundann Noer
  • The risk of leyomyosarcomas in patients undergoing morcillation of fibroids. A national study.

Cervical cancer

  • The department is in the international top of HPV research. The research is performed on some of the largest prospective cohorts in this field and cover all aspects from basic laboratory to clinical research.
  • Fertility serving surgery (Trachelectomy) is one of the main clinical research area as the dept. is the only national center for this type of treatment.
  • Trachelectomy in Denmark. Project Responsible: Laura Amalie Hauerberg Øster

Vulva and vaginal cancer

  • The department is one of the two national centers who treat this type of cancer. The research is mostly clinical oriented with an actual focus on imaging. Translational research is planned to start in 2014.

Responsible editor