At the Department of Growth and Reproduction's outpatient clinic, we see children, adolescents and adult men with the following conditions:
The department follows about 300 patients with growth problems. These include patients with a congenital growth hormone deficiency and patients with growth hormone deficiency caused by radiation of the brain or brain tumour surgery. In addition, growth hormone treatment has been approved for a number of other patient categories, such as girls with Turner syndrome, short children born SGA (Small for Gestational Age), children who are short due to a chronic kidney disease and children with Prader-Willis syndrome.
The department performs diagnostic evaluation and treats girls and boys with precocious puberty (puberty occurring at an unusually young age). In Denmark precocious puberty is traditionally defined by signs of puberty before age 8 years in girls and age 9 years for boys. If the condition is recognized in time, puberty can be curbed medically (with GNRH agonist treatment), which may ease the psychological problems for the child and result in a greater final height.
Disorders of Sex Development (DSD)
The department performs diagnostic evaluation and treats patients from Denmark, Greenland and the Faroe Islands with disorders of sex development (DSD). These include congenital adrenal hyperplasia (CAH) and genetic disorders like Klinefelter’s syndrome and Turner’s syndrome.
The department follows about 150 boys and men with Klinefelter's syndrome. The department has established a Klinefelter's centre, where all patients with Klinefelter's syndrome are offered treatment.
Congenital adrenal hyperplasia
The department follows more than 100 patients from all over Denmark with congenital adrenal hyperplasia (CAH, in Danish known as adrenogenitalt syndrome (AGS)). CAH covers a number of rare congenital diseases, caused by lack of enzymes in the adrenal cortex. Such patients are not able to produce the vital steroid hormone cortisol and in many cases aldosterone.
The department has experienced a growing number of men with fertility problems. These men go through a comprehensive diagnostic evaluation programme to find the reason for their infertility. Among the aetiologies may be obstruction in the sperm duct, lack of spermatogenesis, alterations in genes or chromosomes, or an affected hypothalamus-pituitary-testis hormone axis. The purpose of examinations is partly to give the men an explanation to their infertility, and partly to find a basis for treatment, if possible.
In the sperm bank, men who are about to undergo treatment that potentially could damage their sperm production permanently can deposit their sperm. This treatment includes various types of radiotherapy and chemotherapy as well as some types of arthritis treatment.