The department has a broad research field, often with interdisciplinary clinical projects within the Heart Centre. Below are highlighted areas with ongoing research.
Measurement of cardiac output
New methods for cardiac output measurement is evaluated prior to implementation. There is primarily focus on new, less invasive methods that can provide comparable information to current standards.
The use of heart-lung machine
Cardiac surgery often necessitates the use of a heart-lung machine. Although the technology has improved significantly over the past decades, there remain some associated complications, including postoperative organ failure. There is currently no evidence on the importance of pressure and flow during bypass and how these two components, separately and in conjunction, influence the risk of brain- and kidney-injury. These issues are investigated in both observational and randomized clinical trials.
In the postoperative period after cardiac surgery, both right- and left ventricular heart failure may occur. Management of these clinical conditions, both in terms of diagnosis, monitoring and treatment, will be explored in several research projects. In more severe forms of heart failure, the potential gain from providing mechanical support needs further clarification. Mechanical support can be offered both in heart and /or lung failure as a bridge to recovery or to organ transplantation.
Haemostasis and transfusion
There are several studies indicating that the use of blood component therapy can result in increased morbidity. Cardiac surgery is one of the specialties with the greatest consumption of blood products, as compared to other surgical procedures. Within this research area, the main focus is on establishing well-define transfusion limits as well as an individualized treatment algorithm to reduce the need for transfusion of blood products.
Treatment of delirium in the post-operative period is currently without any evidence of which drug(s) to prefer. The condition is extremely debilitating for the patient and often the cause of a prolonged admission in the intensive care unit. Treatment with rapidly metabolized sedatives and opioids seems more attractive, but to determine superiority of one of these drugs a randomized clinical trial is planned.