HISTORY HISTORY – Herpesvirus Immunology in Solid Organ Transplant Recipients – Liver Transplant Study. Cellular immunological response to cytomegalovirus and varicella-zoster virus infections in liver transplant recipients. Page Content About The HISTORY study aims to investigate immunological and clinical risk factors for cytomegalovirus (CMV) and varicella-zoster virus (VZV) infections in liver transplant recipients. Participants provide blood samples prior to and after liver transplantation. PBMC phenotype and function, concentrations of inflammatory markers and mediators, CMV and VZV viral load and serology and other in-depth immunological analyses are performed in collaboration with the Technical University of Denmark. HISTORY will provide novel insight into the adaptive immunity required for viral control of CMV and VZV in this immunocompromised population.We expect that results from the study will we used to generate algorithms to identify liver transplant recipients at high risk of CMV or VZV infections that could benefit from intensified prophylaxis. Furthermore, results from the study may be used to design new treatment modalities including adoptive T cell transfer.The study protocol has been published and is available from https://doi.org/10.1186/s12879-023-08153-8. Preliminary results Recruitment is ongoing and preliminary results are therefore pending. Project group Department of Infectious Diseases, RigshospitaletSusanne Dam Poulsen, Professor, MD, Senior Consultant (principal investigator responsible for the clinical part)Moises Alberto Suarez Zdunek, MD, PhD StudentSebastian Rask Hamm, MD, PhD StudentAnnemette Hald, Project NurseDepartment of Surgical Gastroenterology, RigshospitaletChristian Ross Pedersen, MD, Associate Professor, Senior ConsultantAllan Rasmussen, MD, Senior ConsultantJens Georg Hillingsø, MD, Associate Professor, Head of DepartmentDepartment of Health Technology, Technical University of DenmarkSine Reker Hadrup, Professor (principal investigator responsible for laboratory analyses)Sunil Kumar Saini, Associate ProfessorFundingThe Novo Nordisk FoundationRigshospitalet Research Council Publications Ongoing PhD-projects"Title pending" - Moises Alberto Suarez Zdunek, MD, Ph.D.-studentPublicationsHerpesvirus Immunology in Solid Organ Transplant Recipients – Liver Transplant Study (HISTORY): a retrospective and prospective observational cohort study. Suarez-Zdunek MA, Saini SK, Pedersen CR, Hamm SR, Hald A, Rasmussen A, Hillingsø JG, Hadrup SR, Nielsen SD. BMC Infect Dis 2023;23:214. DOI: 10.1186/s12879-023-08153-8. Last updated: 28. July 2023 Responsible editor Webgruppen på Rigshospitalet Please give your consent in order to send your message. Please enter a valid email address. Note: This mail is not secure. Your email should therefore not include civil registration numbers or health information.Read how to send secure digital post:https://www.regionh.dk/securemail Write your message: Write your email (Must be filled out): If you wish to attach one or more files you will need to login first. Create account or log in I hereby give my consent to the Capital Region of Denmark to process the information in my enquiry for professional purposes only. Read the terms for your consent No e-mail has been registred for this user/group