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IMMUNEMO

ImmuneMo – Immune function as predictor of infectious complications, treatment response and clinical outcome in patients undergoing different types of “immune modulating" interventi​ons​. A prospective non-interventional observational trial including both patients living with human immunodeficiency virus (HIV), solid organ transplant (SOT) recipients and patients with Infectious spondylodiscitis.


​In ImmuneMo we aim to investigate the relationship between immune function and infectious diseases. Our work is part of a greater study on Rigshospitalet, which includes patients with infections, cancers, and autoimmune diseases. The study involves blood samples analyzed using flow cytometry and the TruCulture® functional assay which assess the innate immune function by whole blood stimulation with Toll-like receptor ligands(1)​

(1) Duffy D, Rouilly V, Braudeau C, Corbière V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen NS, Savenay A, Schmolz M, Toubert A, Albert ML; Multinational FOCIS Centers of Excellence. Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study. Clin Immunol. 2017 Oct;183:325-335. doi: 10.1016/j.clim.2017.09.019. Epub 2017 Sep 22. PMID: 28943400.​

​So far, our study has revealed that immune status plays a role in the susceptibility to infectious diseases, as evidenced by impaired innate immune function observed in patients with infectious spondylodiscitis and HIV. At present, we are assessing if the immune function assessment by TruCulture® can predict viral infection post-transplantation in SOT. ​

Department of Infectious Diseases, Rigshospitalet

  • Susanne Dam Poulsen, Professor, MD, DMSc
  • Dina Leth Møller, MD, PhD Student
  • Malene Hove-Skovsgaard, MD, PhD Student
  • Josefine Amalie Loft, MD
  • Rebekka Faber Thudium, MD, PhD
  • Annemette Hall, Project Nurse

Department of Clinical Immunology 2034, Rigshospitalet

  • Sisse Rye Ostrowski, professor, MD, ph.d., DMSc 

Partners

Department of Infectious Diseases, Rigshospitalet

  • Anne-Mette Lebech, MD, DMSc
  • Jan Gerstoft, Professor, MD, DMSc
  • Åse Bengård Andersen, Chief Physician, MD, DMSc

 PERSIMUNE, Centre of Excellence for Personalized Medicine of Infectious Complications in Immune Deficiency, Rigshospitalet

  • Jens D Lundgren, professor, MD, DMSc

  • Alvaro Borges, MD, ph.d.

Department of Clinical Immunology, Rigshospitalet

  • Morten Bagge Hansen, Chief Physician, MD, DMSc
  • Jakob H von Stemann, MSc, Research Assistant

Department of Abdominal Surgery, Hepatology, Rigshospitalet

  • Allan Rasmussen, MD

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet

  • Barbara Malene Fischer, Associate Professor, MD, ph.d., DMSc

Department of Gynecology and obstetrics, Rigshospitalet

  • Claus Høgdall, Professor, MD
  • Tine Henrichsen Schnack, MD

Department of Anesthesiology, Center for Cancer and Organ Diseases, Rigshospitalet

  • Eske Kvanner Aasvang, Associate Professor, MD, DMSc

Department of Genomic Medicine, Rigshospitalet

  • Finn Cilius Nielsen, Professor, Chief Physician, MD, DMSc
  • Magnus Fontes, Professor, MSc, PhD 

Department of Cardiology, Section for Heart and Lung Transplantation, Rigshospitalet

  • Finn Gustafsson, Professor, MD
  • Michael Perch, MD

Department of Oncology, Rigshospitalet

  • Helle Pappot, professor, MD, DMSc
  • Mette Pøhl, MD, ph.d.

Section for Surgical Pathophysiology, Rigshospitalet

  • Henrik Kehlet, professor, MD, DMSc

Department of Hematology, Rigshospitalet

  • Henrik Sengeløv, MD, DMSc
  • Kirsten Grønbæk, Professor, MD, DMSc

​Department of Medical Gastroenterology, Rigshospitalet

  • Palle Bekker Jeppesen, Professor, MD, DMSc

Department of Rheumatology, Rigshospitalet

  • Søren Jacobsen, Professor, MD, DMSc

​Department of Nephrology, Rigshospitalet

  • Søren Schwartz Sørensen, Professor, MD, DMSc​


Funding​

  • ​The Novo Nordisk Foundation

  • The Augustinus Foundation

  • Independent Research Fund (FSS)

  • Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis' Legat

  • Savværksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat​​


​Ongoing PhD-projects

  • ​​“Immune Function and Infections in Patients Undergoing Solid Organ Transplantation" – Dina Leth Møller, MD, Ph.D.-student

 

Publications

  1. Drabe CH, Sørensen SS, Rasmussen A, Perch M, Gustafsson F, Rezahosseini O, Lundgren JD, Ostrowski SR, Nielsen SD. Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non-interventional observational trial. BMC Infect Dis. 2019 Jul 3;19(1):573. doi: 10.1186/s12879-019-4207-9.

  2. Aasvang EK, Pitter S, Hansen CP, Storkholm JH, Krohn PS, Burgdorf SK, Von Stemann JH, Lundgren JD, Nielsen SD, Kehlet H, Ostrowski SR. Preoperative TruCulture® whole blood cytokine response predicts post-operative inflammation in pancreaticoduodenectomy patients-A pilot cohort study. Scand J Immunol. 2020 Sep;92(3):e12930. doi: 10.1111/sji.12930. Epub 2020 Jul 22.

  3. Rezahosseini O, Møller DL, Knudsen AD, Sørensen SS, Perch M, Gustafsson F, Rasmussen A, Ostrowski SR, Nielsen SD. Use of T Cell Mediated Immune Functional Assays for Adjustment of Immunosuppressive or Anti-infective Agents in Solid Organ Transplant Recipients: A Systematic Review. Front Immunol. 2020 Oct 15;11:567715. doi: 10.3389/fimmu.2020.567715.

  4. Gjaerde LK, Brooks PT, Andersen NS, Friis LS, Kornblit B, Petersen SL, Schjødt I, Nielsen SD, Ostrowski SR, Sengeløv H. Functional immune reconstitution early after allogeneic haematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole blood. Scand J Immunol. 2021 Jul;94(1):e13042. doi: 10.1111/sji.13042. Epub 2021 Apr 12.

  5. Ørbæk M, Gynthersen RMM, Mens H, Stenør C, Wiese L, Brandt C, Ostrowski SR, Nielsen SD, Lebech AM. Stimulated Immune Response by TruCulture<sup>®</sup> Whole Blood Assay in Patients With European Lyme Neuroborreliosis: A Prospective Cohort Study. Front Cell Infect Microbiol. 2021 May 10;11:666037. doi: 10.3389/fcimb.2021.666037.

  6. Gynthersen RMM, Ørbæk M, Mens H, Stenør C, Wiese L, Ostrowski SR, Nielsen SD, Lebech AM. Exploration of the induced cytokine responses in European Lyme neuroborreliosis: A longitudinal cohort study. Ticks Tick Borne Dis. 2023 Jan;14(1):102057. doi: 10.1016/j.ttbdis.2022.102057. Epub 2022 Oct 21.

  7. Loft JA, Møller DL, Thudium RF, Knudsen JD, Ostrowski SR, Andersen ÅB, Nielsen SD. The Induced Immune Response in Patients With Infectious Spondylodiscitis: A Prospective Observational Cohort Study. Front Immunol. 2022 Mar 14;13:858934. doi: 10.3389/fimmu.2022.858934.

  8. Hove-Skovsgaard M, Møller DL, Hald A, Gerstoft J, Lundgren J, Ostrowski SR, Nielsen SD. Improved induced innate immune response after cART initiation in people with HIV. Front Immunol. 2022 Aug 17;13:974767. doi: 10.3389/fimmu.2022.974767.

  9. Ryssel H, Egebjerg K, Nielsen SD, Lundgren J, Pøhl M, Langer SW, Kjaer A, Ostrowski SR, Fischer BM. Innate immune function during antineoplastic treatment is associated with 12-months survival in non-small cell lung cancer. Front Immunol. 2022 Dec 12;13:1024224. doi: 10.3389/fimmu.2022.1024224.

 

Scientific meetings

The European Association of the Study of the Liver Conference 2020, London, England.

  • SAT314: Immune responses before and after liver transplantation: a cohort study of the induced immune response

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