Weischenfeldt Group

​Cancer is a genetic disease and is caused by accumulation of genomic alterations that improve the fitness of the cell. We utilize cancer genomics approaches to characterize the mechanisms, functional consequences and prognostic relevance of genomic alterations in cancer. 

Research focus

​We combine computational and molecular biology approaches to study genotype-phenotype associations in cancer. A particular focus is to gain a better understanding of the functional consequences of large-scale somatic genomic alterations in cancer and how these changes are associated with changes in gene regulation. We are collaborating with clinicians to identify novel biomarkers and to stratify patients based on mutational profiles. A long-term goal is to provide personalized therapeutic intervention options for clinical decision-making.​

Key results

Group leader

Joachim Weischenfeldt obtained his PhD from University of Copenhagen. Following a post doc at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, he started as a group leader at the Finsen Laboratory in September 2015.

Research grants

Our work is funded by:
  • Danish Council for Independent Research
  • Arvid Nilssons fond

Publications

Schlomm, T., Weischenfeldt, J., Korbel, J., & Sauter, G. 2015. The Aging Prostate Is Never "Normal": Implications from the Genomic Characterization of Multifocal Prostate Cancers. Eur Urol, 68(3): 348-350.
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Kluth, M., Galal, R., Krohn, A., Weischenfeldt, J., Tsourlakis, C., Paustian, L., Ahrary, R., Ahmed, M., Scherzai, S., Meyer, A., Sirma, H., Korbel, J., Sauter, G., Schlomm, T., Simon, R., & Minner, S. 2015. Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer. Int J Oncol, 46(4): 1637-1642.

Mardin, B. R., Drainas, A. P., Waszak, S. M., Weischenfeldt, J., Isokane, M., Stutz, A. M., Raeder, B., Efthymiopoulos, T., Buccitelli, C., Segura-Wang, M., Northcott, P., Pfister, S. M., Lichter, P., Ellenberg, J., & Korbel, J. O. 2015. A cell-based model system links chromothripsis with hyperploidy. Mol Syst Biol, 11(9): 828.

Kunz, J. B., Rausch, T., Bandapalli, O. R., Eilers, J., Pechanska, P., Schuessele, S., Assenov, Y., Stutz, A. M., Kirschner-Schwabe, R., Hof, J., Eckert, C., von Stackelberg, A., Schrappe, M., Stanulla, M., Koehler, R., Avigad, S., Elitzur, S., Handgretinger, R., Benes, V., Weischenfeldt, J., Korbel, J. O., Muckenthaler, M. U., & Kulozik, A. E. 2015. Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation. Haematologica.

Steurer, S., Mayer, P. S., Adam, M., Krohn, A., Koop, C., Ospina-Klinck, D., Tehrani, A. A., Simon, R., Tennstedt, P., Graefen, M., Wittmer, C., Brors, B., Plass, C., Korbel, J., Weischenfeldt, J., Sauter, G., Huland, H., Tsourlakis, M. C., Minner, S., & Schlomm, T. 2014. TMPRSS2-ERG Fusions Are Strongly Linked to Young Patient Age in Low-grade Prostate Cancer. Eur Urol.

Brocks, D., Assenov, Y., Minner, S., Bogatyrova, O., Simon, R., Koop, C., Oakes, C., Zucknick, M., Lipka, D. B., Weischenfeldt, J., Feuerbach, L., Cowper-Sal Lari, R., Lupien, M., Brors, B., Korbel, J., Schlomm, T., Tanay, A., Sauter, G., Gerhauser, C., Plass, C., & Project, I. E. O. P. C. 2014. Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer. Cell Rep, 8(3): 798-806.

Weischenfeldt, J., Simon, R., Feuerbach, L., Schlangen, K., Weichenhan, D., Minner, S., Wuttig, D., Warnatz, H. J., Stehr, H., Rausch, T., Jager, N., Gu, L., Bogatyrova, O., Stutz, A. M., Claus, R., Eils, J., Eils, R., Gerhauser, C., Huang, P. H., Hutter, B., Kabbe, R., Lawerenz, C., Radomski, S., Bartholomae, C. C., Falth, M., Gade, S., Schmidt, M., Amschler, N., Hass, T., Galal, R., Gjoni, J., Kuner, R., Baer, C., Masser, S., von Kalle, C., Zichner, T., Benes, V., Raeder, B., Mader, M., Amstislavskiy, V., Avci, M., Lehrach, H., Parkhomchuk, D., Sultan, M., Burkhardt, L., Graefen, M., Huland, H., Kluth, M., Krohn, A., Sirma, H., Stumm, L., Steurer, S., Grupp, K., Sultmann, H., Sauter, G., Plass, C., Brors, B., Yaspo, M. L., Korbel, J. O., & Schlomm, T. 2013a. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell, 23(2): 159-170.

Weischenfeldt, J., Symmons, O., Spitz, F., & Korbel, J. O. 2013b. Phenotypic impact of genomic structural variation: insights from and for human disease. Nat Rev Genet, 14(2): 125-138.

Rausch, T., Jones, D., Zapatka, M., Stutz, A., Zichner, T., Weischenfeldt, J., Jager, N., Remke, M., Shih, D., Northcott, P., Pfaff, E., Tica, J., Wang, Q., Massimi, L., Witt, H., Bender, S., Pleier, S., Cin, H., Hawkins, C., Beck, C., von Deimling, A., Hans, V., Brors, B., Eils, R., Scheurlen, W., Blake, J., Benes, V., Kulozik, A., Witt, O., Martin, D., Zhang, C., Porat, R., Merino, D., Wasserman, J., Jabado, N., Fontebasso, A., Bullinger, L., Rucker, F., Dohner, K., Dohner, H., Koster, J., Molenaar, J., Versteeg, R., Kool, M., Tabori, U., Malkin, D., Korshunov, A., Taylor, M., Lichter, P., Pfister, S., & Korbel, J. 2012. Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations. Cell, 148(1-2): 59-71.

Jones, D. T. W., Jäger, N., Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y.-J., Pugh, T. J., Hovestadt, V., Stütz, A. M., Rausch, T., Warnatz, H.-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A., Remke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, J., Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U. D., Wang, Q., Lasitschka, B., Bartholomae, C. C., Schmidt, M., Von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., Van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M. J., Russell, R. B., Coco, S., Tonini, G. P., Schüller, U., Hans, V., Graf, N., Kim, Y.-J., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A. E., Von Deimling, A., Witt, O., Maass, E., Rössler, J., Ebinger, M., Schuhmann, M. U., Frühwald, M. C., Hasselblatt, M., Jabado, N., Rutkowski, S., Von Bueren, A. O., Williamson, D., Clifford, S. C., Mccabe, M. G., Collins, V. P., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P. A., Taylor, M. D., Meyerson, M., Pomeroy, S. L., Yaspo, M.-L., Korbel, J. O., Korshunov, A., Eils, R., Pfister, S. M., & Lichter, P. 2012. Dissecting the genomic complexity underlying medulloblastoma. Nature, 488(7409): 100-105.

Weischenfeldt, J., Waage, J., Tian, G., Zhao, J., Damgaard, I., Jakobsen, J. S., Kristiansen, K., Krogh, A., Wang, J., & Porse, B. T. 2012. Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome biology, 13(5): R35.

Thoren, L. A., Nørgaard, G. A., Weischenfeldt, J., Waage, J., Jakobsen, J. S., Damgaard, I., Bergström, F. C., Blom, A. M., Borup, R., Bisgaard, H. C., & Porse, B. T. 2010. UPF2 Is a Critical Regulator of Liver Development, Function and Regeneration. PloS one, 5(7): e11650.

Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C., & Porse, B. T. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes & Development, 22(10): 1381-1396.

Weischenfeldt, J., & Porse, B. 2008. Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. CSH Protoc, 2008: pdb.prot5080.​


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