The Porse Group is part of the Section for stem and cancer stem cell biology.
Several cancers, including acute myeloid leukemias (AML), are maintained by Cancer Stem Cells (CSCs). Similar to normal stem cells, CSCs are able to self-renew and are thus the cells that need to be targeted in order to efficiently eradicate the disease. The focus of the Porse group is therefore to study cancer from a stem-cell centric viewpoint. Specifically, we address the molecular mechanisms governing both normal and malignant hematopoiesis with the aim to identify novel targets for future therapeutic intervention in patients suffering from AML.
Hasemann MS, Lauridsen FKB, Waage J, Jakobsen JS, Frank A-K, Schuster MB, Rapin N, Bagger FO, Hoppe PS, Schroeder T, Porse BT (2014) C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors, PLoS Genet., 10, e1004079
Ohlsson E, Hasemann MS, Willer A, Lauridsen FKB, Rapin N, Jendholm J, Porse BT (2014) Initiation of MLL-rearranged AML is dependent on C/EBPα. J. Exp. Med., 211, 5-13
Rapin N, Bagger FO, Jendholm J, Mora-Jensen H, Krogh A, Kohlmann A, Thiede C, Borregaard N, Bullinger L, Winther O, Theilgaard-Mönch K, Porse BT (2014) Comparing cancer vs. normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients. Blood, 123, 894-904
Bagger FO, Rapin N, Theilgaard-Mönch K, Kaczkowski B, Thoren LA, Jendholm J, Winther O and Porse B (2013) HemaExplorer: A database of mRNA expression profiles in normal and malignant hematopoiesis. Nucleic Acids Research, 41(D1), D1034-D1039
Weischenfeldt J, Waage J, Tian G, Zhao J, Damgaard I, Jakobsen JS, Kristiansen K, Krogh A, Wang J and Porse BT (2012) Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns. Genome Biology, 13, R35
Zheng S, Gray EE, Chawla G, Porse BT, O´Dell TJ, Black DL (2012) Psd-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2. Nat Neurosci., 15, 381-388
Marstrand TT, Borup R, Willer A, Borregaard N, Sandelin A, Porse BT and Theilgaard-Mönch (2010) A conceptual framework for the identification of candidate drugs and drug targets in acute promyelocytic leukemia. Leukemia, 24, 1265-1275. Epub 2010 May 27.
Weischenfeldt J, Damgaard I, Bryder D, Theilgaard-Mönch K, Thoren LA, Nielsen FC, Jacobsen SE, Nerlov C and Porse BT (2008) NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev., 22, 1381-1396