Henrik Gårdsvoll

Henrik Gårdsvoll ​​​
Senior Scientist, PhD
Behrendt Group
Telephone: 35 45 60 38
Email: henrik.gaardsvoll@regionh.dk and gvoll@finsenlab.dk

Key research interests

Protein structure function studies of LU protein domain family members.

Key publications

Gårdsvoll H, M.C. Kriegbaum, E.P. Hertz, W. Alpízar-Alpízar, and M. Ploug: “The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia”. Journal of Histochemistry and  Cytochemistry, 2013, 61, 802-13.​ 

Xu, X., H. Gårdsvoll, C. Yuan, L. Lin, M. Ploug, and M. Huang:
Crystal structure of the urokinase receptor in a ligand-free form
Journal of Molecular Biology, 2012, 416, 629-641.

Gårdsvoll, H., M. Kjaergaard, B. Jacobsen, M. Kriegbaum, M. Huang, and M. Ploug:
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.
Journal of Biological Chemistry, 2011, 286, 43515-43526.

Gårdsvoll, H., B. Jacobsen, M. Kriegbaum, N. Behrendt, L. Engelholm, S. Østergaard, and M. Ploug:
Conformational regulation of urokinase receptor (uPAR) function. Impact of receptor occupancy and of epitope-mapped monoclonal antibodies on lamellipodia induction.
Journal of Biological Chemistry, 2011,286, 33544-33556.

Lin, L., H. Gårdsvoll, Q. Huai, M. Huang, and M. Ploug:
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor. Implication for preclinical cancer therapy.
Journal of Biological Chemistry, 2010, 285, 10982-10992.

Gårdsvoll, H. and M. Ploug:
"Mapping of the vitronectin binding site on the urokinase receptor. Involvement of a composite interface of domain I and the flanking interdomain linker region."
Journal of Biological Chemistry, 2007, 282: 13561-13572.

Gårdsvoll, H., B. Gilquin, M. H. Le Du, A. Menez, T. J. D. Jørgensen, and M. Ploug:
"Characterization of the functional epitope on uPAR for uPA. Complete alanine scanning mutagenesis of uPAR supplemented by chemical crosslinking."
Journal of Biological Chemistry, 2006, 281: 19260-19272.

Llinas, P., M. H. Le Du, Gårdsvoll, H., K. Danø, M. Ploug, B. Gilquin, E. A. Stura and A. Menez:
"Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide."
The EMBO journal, 2005, 24: 1655-1663.

Gårdsvoll, H., F. Werner, L. Søndergaard, K. Danø, and M. Ploug:
"Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites"
Protein Expression and Purification, 2004, 34: 284-295.

Gårdsvoll, H., H. Solberg, K. Danø and G. Høyer-Hansen: "Generation of high affinity rabbit polyclonal antibodies to the murine urokinase receptor using DNA immunization."
Journal of Immunological Methods, 2000, 234: 107-116.

Career

Post-doctoral positions:
1994 - present The Finsen Laboratory
1993-94 Department of Biochemistry, Faculty of Medicine, University of Amsterdam, headed by professor Hans Pannekoek

Scientific degrees:
1993 Ph.D., Faculty of Medicine, University of Copenhagen
1989-93 Ph.D.-student at The Protein Laboratory. Adviser professor Elisabeth Bock
1989 Master of Science, Biology
1986-89 Master thesis studies performed at The Protein Laboratory, Faculty of Medicine, University of Copenhagen. Adviser professor Elisabeth Bock, The Protein Laboratory.

 

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