Key research topics
My main fields of interest are methodology development of functional MRI and clinical application of new functional and molecular MR methods with the aim of obtaining information about tissue physiology, organ perfusion and molecular biology in brain, heart, and kidney.
My present research focus on detailed studies of the relationship between evoked potentials and BOLD fMRI imaging, with the aim of development a setup whereby the neurovascular coupling can be studied in healthy volunteers and in various diseases. Both the visual system and the somatosensory system are being studied. Additionally, ongoing research focus on the negative BOLD fMRI signal which can be elicited under certain condition during somatosensoric stimulation. Another area of methodological MRI studies focus at development of a new brain perfusion method, and this method has just been published. An extension of this method allows us to concurrently calculate the blood brain barrier permeability, and we have for the first time presented measures of the normal blood brain barrier permeability (for a common usable MR contrast agent) which previously had been assumed equal to zero. I am leading a number of clinical related studies in cooperation with various clinical departments. Most notable, all patients with optic neuritis are investigated with a large battery of functional MRI methods.
Furthermore, patients with brain tumors are investigated with BOLD fMRI and diffusion tensor and perfusion imaging before surgery in order to localize important functional brain centres. Development of MRI methods for detection of myocardial viability after acute myocardial infarction based on measurements of perfusion and markers of Ca2+ fluxes in the myocardial tissue is also of my research interest.