Staff


Bente Sonne Møller - Radiographer, MRT
Super user on our 3T system. Working part time with research at the Functional Imaging Unit and part time with clinical patients at the Radiology Department.

E-mail: bente.s​onne.moeller@​regionh.dk​




Affiliated to the Functional Imaging Unit via employment at Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS).

Part of VIP 'Vulnerability Indicators of Psychosis; A Twin Study'. My involvement is regarding glutamate and changes in cortical thickness/surface in relation to schizophrenia.

See Curriculum Vitae​ (pdf, opens in a new tab)


Research/PhD-project
The HPA (Hypothalamus, Pituitary & Adrenal Gland) axis in the early phases of psychosis.

Short description of project:
Several international studies have focused on patient groups at ultra high risk (UHR) of developing psychosis and the possibilities for intervention before onset of psychosis. More knowledge about the biological mechanisms involved in the pathogenesis of psychosis can give a better understanding of the processes involved and thereby form a foundation for future interventions. It is well recognized that stress response can differ in patients with first episode psychosis compared to healthy controls, and that patients at high risk for transition to psychosis also have abnormal function in these dimensions.

Different kinds of treatments/intervention offered can delay, if not prevent the onset of psychosis. But still we treat many patients who might never develop psychosis. It would be interesting if we could identify further predictors, e.g. biological predictors.

Cortisol seems to be an important factor in the biology of psychoses, in particular patients with acute psychotic symptoms show hyperactivity of the HPA axis, as demonstrated by increased levels of cortisol, non-suppression at the dexamethasone depression test and an enlarged pituitary volume. It also seems that the increased volume of the pituitary gland is not only present at the first episode of psychosis, but even just prior to the onset of psychosis, and according to some studies, it predicts the future onset of psychosis. Such findings suggest that HPA axis activity could be used to monitor the future course of the disorder. The relationship between cortisol levels, the diurnal variation of cortisol and volume of the pituitary gland and thalamus and psychopathology has been studied very little in schizophrenic patients. In this study we measure the volume of the pituitary gland by manual tracing on structural scanning, and relate this to the salivary cortisol (6 samples from awakening until evening), stress scales and psychopathology in UHR subjects, psychotic patients and healthy subjects.

We expect including forty UHR subjects and we will compare them with forty first-episode psychosis (FEP) subject from the PECANS study and forty healthy controls.

See Curriculum Vitae​ (pdf, opens in a new tab)
Publication list
1. Sidaros A, Skimminge A, Liptrot MG, Sidaros K, Engberg AW, Herning M, Paulson OB, Jernigan TL, Rostrup E. Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates. Neuroimage. In Press 2008.

2. Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund LO, Basile AM, Pantoni L, Inzitari D, Waldemar G, Group LADISS. White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study. AJNR American journal of neuroradiology. 2008;29:1498-1504.

3. Giménez M, Miranda MJ, Born AP, Nagy Z, Rostrup E, Jernigan TL. Accelerated cerebral white matter development in preterm infants: A voxel-based morphometry study with diffusion tensor MR imaging. Neuroimage. 2008;41:728-734.

4. Kalowska E, Rostrup E, Rosenbaum S, Petersen P, Paulson OB. Acute MRI changes in progressive ischemic stroke. Eur Neurol. 2008;59:229-236.

5. Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G, group obotLADISs. Segmentation of age-related white matter changes in a clinical multi-center study. Neuroimage. 2008;41:335-345.

6. Sidaros A, Engberg AW, Sidaros K, Liptrot MG, Herning M, Petersen P, Paulson OB, Jernigan TL, Rostrup E. Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain. 2008;131:559-572.

7. Larsson HB, Hansen AE, Berg HK, Rostrup E, Haraldseth O. Dynamic contrast-enhanced quantitative perfusion measurement of the brain using T(1)-weighted MRI at 3T. Journal of magnetic resonance imaging : JMRI. 2008;27:754-762.

8. Jokinen H, Ryberg C, Kalska H, Ylikoski R, Rostrup E, Stegmann MB, Waldemar G, Madureira S, Ferro JM, van Straaten EC, Scheltens P, Barkhof F, Fazekas F, Schmidt R, Carlucci G, Pantoni L, Inzitari D, Erkinjuntti T, group LADIS. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study. J Neurol Neurosurg Psychiatr. 2007;78:491-496.

9. Ryberg C, Rostrup E, Stegmann M, Barkhof F, Scheltens P, Vanstraaten E, Fazekas F, Schmidt R, Ferro J, Baezner H. Clinical significance of corpus callosum atrophy in a mixed elderly population. Neurobiology of Aging. 2007;28:955-963.

10. Habekost T, Rostrup E. Visual attention capacity after right hemisphere lesions. Neuropsychologia. 2007;45:1474-1488.

11. Korf ES, van Straaten EC, de Leeuw FE, van der Flier WM, Barkhof F, Pantoni L, Basile AM, Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, Scheltens P, Group LADISS. Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study. Diabet Med. 2007;24:166-171.

12. Sjöstrand K, Rostrup E, Ryberg C, Larsen R, Studholme C, Baezner H, Ferro J, Fazekas F, Pantoni L, Inzitari D, Waldemar G, Group LADISS. Sparse decomposition and modeling of anatomical shape variation. IEEE transactions on medical imaging. 2007;26:1625-1635.

13. Jokinen H, Ryberg C, Kalska H, Ylikoski R, Rostrup E, Stegmann M, Waldemar G, Madureira S, Ferro J, Van Straaten E, Scheltens P, Barkhof F, Fazekas F, Schmidt R, Carlucci G, Pantoni L, Inzitari D, Erkinjuntti T. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study. Journal of Neurology, Neurosurgery & Psychiatry. 2006;78:491-496.

14. van Straaten EC, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D, Waldemar G, Erkinjuntti T, Mäntylä R, Wahlund L, Barkhof F, group LADIS. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke. 2006;37:836-840.

15. Habekost T, Rostrup E. Persisting asymmetries of vision after right side lesions. Neuropsychologia. 2006;44:876-895.

16. Garde E, Lykke Mortensen E, Rostrup E, Paulson OB. Decline in intelligence is associated with progression in white matter hyperintensity volume. J Neurol Neurosurg Psychiatr. 2005;76:1289-1291.

17. van der Flier WM, van Straaten EC, Barkhof F, Ferro JM, Pantoni L, Basile AM, Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, Scheltens P, Group LADISS. Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study. J Neurol Neurosurg Psychiatr. 2005;76:1497-1500.

18. Jelsing J, Rostrup E, Markenroth K, Paulson OB, Gundersen HJ, Hemmingsen R, Pakkenberg B. Assessment of in vivo MR imaging compared to physical sections in vitro--a quantitative study of brain volumes using stereology. Neuroimage. 2005;26:57-65.

19. Lund T, Norgaard M, Rostrup E, Rowe J, Paulson OB. Motion or activity: their role in intra- and inter-subject variation in fMRI. NeuroImage. 2005;26:960-964.

20. Rostrup E, Knudsen G, Law I, Holm S, Larsson H, Paulson OB. The relationship between cerebral blood flow and volume in humans. NeuroImage. 2005;24:1-11.

21. Rostrup E, Larsson H, Born AP, Knudsen G, Paulson OB. Changes in BOLD and ADC weighted imaging in acute hypoxia during sea-level and altitude adapted states. NeuroImage. 2005;28:947-955.

22. Mathiesen H, Tscherning T, Sorensen P, Larsson H, Rostrup E, Paulson OB, Hanson L. Multi-slice echo-planar spectroscopic MR imaging provides both global and local metabolite measures in multiple sclerosis. Magn Reson Med. 2005;53:750-759.

23. Cohen ER, Rostrup E, Sidaros K, Lund TE, Paulson OB, Ugurbil K, Kim SG. Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences. Neuroimage. 2004;23:613-624.

24. Knudsen G, Rostrup E, Hasselbalch S. Quantitative PET for assessment of cerebral blood flow and glucose consumption under varying physiological conditions. International Congress Series. 2004;1265:189-200.

25. Ejbjerg B, Narvestad E, Rostrup E, Szkudlarek M, Jacobsen S, Thomsen H, Stergaard M. Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis. Arthritis & Rheumatism. 2004;50:1097-1106 http://www3.interscience.wiley.com/journal/76509746/home?CRETRY=1​&SRETRY=0.

26. Olsen DB, Langkilde AR, Ørngreen MC, Rostrup E, Schwartz M, Vissing J. Muscle structural changes in mitochondrial myopathy relate to genotype. J Neurol. 2003;250:1328-1334.

27. Rostrup E, Law I, Pott F, Ide K, Knudsen GM. Cerebral hemodynamics measured with simultaneous PET and near-infrared spectroscopy in humans. Brain Res. 2002;954:183-193.

28. Born AP, Law I, Lund TE, Rostrup E, Hanson L, Wildschiødtz G, Lou HC, Paulson OB. Cortical deactivation induced by visual stimulation in human slow-wave sleep. Neuroimage. 2002;17:1325-1335.

29. Langkilde AR, Frederiksen JL, Rostrup E, Larsson HB. Functional MRI of the visual cortex and visual testing in patients with previous optic neuritis. Eur J Neurol. 2002;9:277-286.

30. Born AP, Rostrup E, Miranda MJ, Larsson HB, Lou HC. Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR). Magnetic Resonance Imaging. 2002;20:199-205.

31. Paulson OB, Born AP, Bundesen C, Gade A, Gerlach C, Hansen LK, Holm S, Jensen M, Kyllingsbaek S, Larsen A, Law I, Rostrup E, Svarer C. [The working brain--how does it look like?]. Ugeskr Laeg. 2002;164:2267-2275.

32. Marstrand JR, Garde E, Rostrup E, Ring P, Rosenbaum S, Mortensen EL, Larsson HB. Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities. Stroke. 2002;33:972-976.

33. Marstrand JR, Rostrup E, Rosenbaum S, Garde E, Larsson HB. Cerebral hemodynamic changes measured by gradient-echo or spin-echo bolus tracking and its correlation to changes in ICA blood flow measured by phase-mapping MRI. Journal of magnetic resonance imaging : JMRI. 2001;14:391-400.

34. Goutte C, Hansen LK, Liptrot MG, Rostrup E. Feature-space clustering for fMRI meta-analysis. Human brain mapping. 2001;13:165-183.

35. Sidaros K, Andersen IK, Gesmar H, Rostrup E, Larsson HB. Improved perfusion quantification in FAIR imaging by offset correction. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2001;46:193-197.

36. Andersen IK, Sidaros K, Gesmara H, Rostrup E, Larsson HB. A model system for perfusion quantification using FAIR. Magnetic Resonance Imaging. 2000;18:565-574.

37. Klarlund M, Ostergaard M, Rostrup E, Skjødt H, Lorenzen I. Dynamic magnetic resonance imaging of the metacarpophalangeal joints in rheumatoid arthritis, early unclassified polyarthritis, and healthy controls. Scand J Rheumatol. 2000;29:108-115.

38. Rostrup E, Law I, Blinkenberg M, Larsson HB, Born AP, Holm S, Paulson OB. Regional differences in the CBF and BOLD responses to hypercapnia: a combined PET and fMRI study. Neuroimage. 2000;11:87-97.

39. Born AP, Miranda MJ, Rostrup E, Toft PB, Peitersen B, Larsson HB, Lou HC. Functional magnetic resonance imaging of the normal and abnormal visual system in early life. Neuropediatrics. 2000;31:24-32.

40. Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet. 2000;356:628-634.

41. Law I, Iida H, Holm S, Nour S, Rostrup E, Svarer C, Paulson OB. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: II. Normal values and gray matter blood flow response to visual activation. J Cereb Blood Flow Metab. 2000;20:1252-1263.

42. Hansen LK, Larsen J, Nielsen FA, Strother SC, Rostrup E, Savoy R, Lange N, Sidtis J, Svarer C, Paulson OB. Generalizable patterns in neuroimaging: how many principal components? Neuroimage. 1999;9:534-544.

43. Goutte C, Toft P, Rostrup E, Nielsen F, Hansen LK. On clustering fMRI time series. Neuroimage. 1999;9:298-310.

44. Kim SG, Rostrup E, Larsson HB, Ogawa S, Paulson OB. Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1999;41:1152-1161.

45. Born AP, Leth H, Miranda MJ, Rostrup E, Stensgaard A, Peitersen B, Larsson HB, Lou HC. Visual activation in infants and young children studied by functional magnetic resonance imaging. Pediatric Research. 1998;44:578-583.

46. Fritz-Hansen T, Rostrup E, Ring PB, Larsson HB. Quantification of gadolinium-DTPA concentrations for different inversion times using an IR-turbo flash pulse sequence: a study on optimizing multislice perfusion imaging. Magnetic Resonance Imaging. 1998;16:893-899.

47. Law I, Svarer C, Rostrup E, Paulson OB. Parieto-occipital cortex activation during self-generated eye movements in the dark. Brain. 1998;121:2189-2200.

48. Fritz-Hansen T, Rostrup E, Søndergaard L, Ring PB, Amtorp O, Larsson HB. Capillary transfer constant of Gd-DTPA in the myocardium at rest and during vasodilation assessed by MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1998;40:922-929.

49. Larsson HB, Rostrup E. [Functional MR imaging of CNS]. Ugeskr Laeg. 1997;159:6659-6665.

50. Rostrup E, Larsson HB, Toft PB, Garde K, Ring PB, Henriksen O. Susceptibility contrast imaging of CO2-induced changes in the blood volume of the human brain. Acta radiologica (Stockholm, Sweden : 1987). 1996;37:813-822.

51. Larsson HB, Fritz-Hansen T, Rostrup E, Søndergaard L, Ring P, Henriksen O. Myocardial perfusion modeling using MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1996;35:716-726.

52. Born AP, Rostrup E, Leth H, Peitersen B, Lou HC. Change of visually induced cortical activation patterns during development. Lancet. 1996;347:543.

53. Fritz-Hansen T, Rostrup E, Larsson HB, Søndergaard L, Ring P, Henriksen O. Measurement of the arterial concentration of Gd-DTPA using MRI: a step toward quantitative perfusion imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 1996;36:225-231.

54. Garde K, Rostrup E, Toft PB, Henriksen O. Cerebral energy metabolism during hypoxaemia. A 31P and 1H magnetic resonance study. Acta Physiol Scand. 1995;154:185-191.

55. Rostrup E, Larsson HB, Toft PB, Garde K, Henriksen O. Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia. NMR Biomed. 1995;8:41-47.

56. Rostrup E, Larsson HB, Toft PB, Garde K, Thomsen C, Ring P, Søndergaard L, Henriksen O. Functional MRI of CO2 induced increase in cerebral perfusion. NMR Biomed. 1994;7:29-34.

57. Höök M, Christoffersen J, Christoffersen MR, Leonardsen ES, Rassing MR, Rostrup E. Effects of aluminum (III) and fluoride on the demineralization of bovine enamel: a longitudinal microradiographic study. Scandinavian journal of dental research. 1994;102:198-201.

58. Henriksen O, Larsson HB, Ring P, Rostrup E, Stensgaard A, Stubgaard M, Ståhlberg F, Söndergaard L, Thomsen C, Toft P. Functional MR imaging at 1.5 T. Initial results using photic and motoric stimulation. Acta radiologica (Stockholm, Sweden : 1987). 1993;34:101-103.

59. Tuxen A, Rostrup E. Histochemical characterization of pig masseter muscle: an animal model. Scandinavian journal of dental research. 1993;101:57-61.

60. Kiehn O, Rostrup E, Møller M. Monoaminergic systems in the brainstem and spinal cord of the turtle Pseudemys scripta elegans as revealed by antibodies against serotonin and tyrosine hydroxylase. J Comp Neurol. 1992;325:527-547.

61. Gotfredsen K, Rostrup E, Hjörting-Hansen E, Stoltze K, Budtz-Jörgensen E. Histological and histomorphometrical evaluation of tissue reactions adjacent to endosteal implants in monkeys. Clinical oral implants research. 1991;2:30-37. ​

62. Christoffersen J, Christoffersen MR, Larsen R, Rostrup E, Tingsgaard P, Andersen O, Grandjean P. Interaction of cadmium ions with calcium hydroxyapatite crystals: a possible mechanism contributing to the pathogenesis of cadmium-induced bone diseases. Calcif Tissue Int. 1988;42:331-339.

E-mail: egiros0​1@glo.reg​ionh.dk

Doctor thesis: Basic physiology of BOLD imaging​​​ (pdf, opens in a new tab)
See Curriculum Vitae​ (pdf, opens in a new tab)







Helle Juhl Simo​nsen - ​​Reseach MRT, Biomedical Laboratory Scientist​
Background
Have been working with MR research since 1987. Supported many Ph.D. students with data recording and analysis. Experienced with both human and pre-clinical studies using MR imaging, spectroscopy, diffusion, perfusion and fMRI.

3rd place award in the category of Research Focus Proffered Paper, SMRT & BAMRR 18th Annual Meeting 2009, Hawai’i Convention Center, Honolulu, Oahu, USA.

3rd Place Clinical Focus Poster Award SMRT & B​​​AMRR 20th Annual Meeting 2011; Montréal, Québec, Canada​

3rd Place Clinical Focus Poster Award SMRT & BAMRR 20th Annual Meeting 2012; Melbourne, Victoria, Australia

E-mail: helle.juhl.simonsen@regionh.dk​​

See Curriculum Vitae​ (pdf, opens in a new tab)
Key research topics
My main fields of interest are methodology development of functional MRI and clinical application of new functional and molecular ​MR methods with the aim of obtaining information about tissue physiology, organ perfusion and molecular biology in brain, heart, and kidney.

My present research focus on detailed studies of the relationship between evoked potentials and BOLD fMRI imaging, with the aim of development a setup whereby the neurovascular coupling can be studied in healthy volunteers and in various diseases. Both the visual system and the somatosensory system are being studied. Additionally, ongoing research focus on the negative BOLD fMRI signal which can be elicited under certain condition during somatosensoric stimulation. Another area of methodological MRI studies focus at development of a new brain perfusion method, and this method has just been published. An extension of this method allows us to concurrently calculate the blood brain barrier permeability, and we have for the first time presented measures of the normal blood brain barrier permeability (for a common usable MR contrast agent) which previously had been assumed equal to zero. I am leading a number of clinical related studies in cooperation with various clinical departments. Most notable, all patients with optic neuritis are investigated with a large battery of functional MRI methods.

​Furthermore, patients with brain tumors are investigated with BOLD fMRI and diffusion tensor and perfusion imaging before surgery in order to localize important functional brain centres. Development of MRI methods for detection of myocardial viability after acute myocardial infarction based on measurements of perfusion and markers of Ca2+ fluxes in the myocardial tissue is also of my research interest.

E-mail: henrik.larsson@regionh.dk

See publication list (pdf, opens in a new tab)

See Curriculum Vitae​ (pdf, opens in a new tab)
​Affiliated to the Functional Imaging Unit via employment at Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS).

Involved in the following projects:

OPTiMiSE - Optimisation of Treatment and Management of Schizophrenia in Europe.

The study recruits first episode schizophrenia patients and the purpose is two-sided: to optimize current treatment algoritms and find novel pathways for new treatments. Investigations will include neurocognitive testing as well as MRI/MRS.

Visit http://www​.optimisetrial.eu/ for more infomation.

And PECANS (Pan European Collaboration on Antipsycotic Naïve Schizophrenia). The study recruits first episode schizophrenia patients and the purpose is to find a valid biological integrated model for schizophrenia. In the long term the aim is to predict treatment response and individualise treatment.

See Curricul​um Vitae​ (pdf, opens in a new tab)
Jayachandra. M. R. - Senior Scientist, Ph.D.
See Curriculum Vitae​ (pdf, opens in a new tab)







Karina Elin Segers - ​​Radiographer, MRT
Super user on our 3T system. Working part time with research at the Functional Imaging Unit and part time with clinical patients at the Radiology Department.

Email: karina.elin.segers@regionh.dk​​

See Curriculum Vitae​​ (pdf, opens in a new tab)


Affiliated to the Functional Imaging Unit via employment at Center for Neurops​ychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS).

Involved in the following projects:

PECANS I and II (Pan European Collaboration on Antipsycotic Naïve).

The study r​ecruits first episode schizophrenia patients and is an investigation of structural changes before and after antipsychotic mono-terapy. Furthermore, these structural changes will be linked to glutamate and dopamine levels.

See Curriculum Vitae​ (pdf, opens in a new tab)
Affiliated to the Functional Imaging Unit via the Center of Neuropsychiatric Schizophrenia Research and Psychiatric Center Glostrup.

Currently involved in MR investigations of schizophrenia, including studies of experimentally induced non-paranoid psycosis by ketamine-infusion. Methods include MRS and ASL.

See Curriculum Vitae​ (pdf, opens in a new tab)


​​PECANS II (Pan European Collaboration on Antipsych​otic Naïve Schizophrenia II)
- Glutamatergic and GABAergic disturbances as markers of choice-of-treatment


Insufficient response to antipsychotic drugs constitutes one of the major challenges in the treatment of patients suffering from schizophrenia and therefore other targets than the dopamine D2 receptor are highly warranted. Glutamate constitutes the main excitatory neurotransmitter in the brain and growing evidence supports that glutamatergic disturbances substantially contribute to the pathophysiology of schizophrenia. However, the relation between disturbances in glutamatergic turnover and specific clinical symptoms is largely unknown, and as a result the efforts to relieve symptoms of schizophrenia by agents modulating glutamate neurotransmission have not yet been successful.

In humans, proton magnetic resonance spectroscopy (1H-MRS) can be used to assess glutamate levels. The few existing 1H-MRS studies of patients with schizophrenia suggest increased levels of glutamate and increased glutamate turnover in the anterior cingulate cortex (ACC) of antipsychotic-naïve and minimally treated young patients with schizophrenia. Moreover, glutamatergic dysfunction in ACC has also been associated with insufficient response to antipsychotic treatment.

The objective of this study is to investigate the glutamatergic turnover in the two connected areas ACC and thalamus in a large cohort of initially antipsychotic-naïve first-episode patients with schizophrenia and matched healthy controls. The glutamatergic turnover will be related to clinical symptoms and level of functioning before and after 6 weeks of treatment with the antipsychotic compound aripiprazole.

The Ph.D. project is part of PECANS II that is a collaborative study between Center for Neuropsychiatric Schizophrenia Research (CNSR), Copenhagen Universuty Hospital, Psychiatric Center Glostrup and Functional Imaging Unit (FIU), Glostrup Hospital​.

Inclusion is expected to start in January 2014 and last until December 2018.

Results from this study will add important pathophysiological insights into the implications of glutamatergic disturbances before antipsychotic treatment is initiated. The monotherapeutic design with aripiprazole will provide pivotal new insights into the interaction between glutamatergic disturbances, clinical symptoms and level of functioning. Thus, the present study constitutes a pertinent step towards improving the treatment options for patients suffering from schizophrenia.

See Curriculum Vitae​ (pdf, opens in a new tab)
Research/PhD-project:
Exploring clinical, cognitive, and brain structural predictors of ´risk resolution´ in individuals at ultra-high risk for schizophrenia


Intensive research is being done in order to identify young individuals at risk of developing schizophrenia since early intervention may delay or even prevent overt disease. Specific criteria have been developed that combine subtreshold- or attenuated psychotic symptoms, genetic predisposition and a significant decline in functioning in order to identify individuals at ultra-high risk (UHR) of developing a psychosis.

Early studies in these UHR individuals found that 30-50 % developed a psychosis within 1-2 years. However, more recent studies have reported a steady decline in transition rates to around 12 %.

Until now no studies have investigated the large group of individuals who do not progress to psychosis but who remain in UHR or whose symptoms resolve. Identification of biological or functional predictors of ‘risk resolution’ in these individuals may serve as refined tools of risk stratification within the group of high risk patients. Ultimately, such tools may facilitate early and personalized intervention targeted towards individuals who are at continuous risk for developing schizophrenia.

We will try to characterize UHR individuals by testing cognitive, olfactory and brain structural domains that are known to be impaired in schizophrenia patients, and compare them to healthy controls.

We will also try to find predictors of risk resolution in UHR individuals by correlating changes in tensor based morphometry and risk status at one year follow-up.

Additionally we will use multivariate analysis (a support vector machine) to try to identity patterns of clinical, cognitive and brain structural markers, which can predict the risk resolution in UHR individuals at an individual level.

So far 40 individuals have been included and tested with MRI-scans, psychometric- and cognitive tests. One year follow up has been done on 20 UHR individuals.

See Curriculum Vitae​ (pdf, opens in a new tab)
fMRI for studying pain physiology

Functional imaging may contribute to a better understanding on how pain is endogenously processed. Functional MR imaging is used in this study to analyse the BOLD response to mechanical stimulation in an area of secondary hyperalgesia after a first degree burn injury.

See Curriculum Vitae​ (pdf, opens in a new tab)


Mark Vestergaard - Postdoc, Ph.D.
Key research topics 
Cerebral perfusion, oxygen metabolism and lactate production during metabolic and hypoxic stress. Measurement of cerebral pathophysiology in various diseases (e.g. cerebrovascular disease, stroke, obstructive sleep apnea, migraine) using non-invasive magnetic resonance imaging and spectroscopy techniques.

See Curriculum Vitae​ (pdf, opens in a new tab)


See Curriculum Vitae​ (pdf, opens in a new tab)







See Curriculum Vitae (pdf, opens in a new tab)

Publication list​ (pdf, opens in a new tab)​





See Curriculum Vitae​ (pdf, opens in a new tab)







Affiliated to the Functional Imaging Unit via employment at Center for Neuropsychiatric Schizophrenia Research (CNSR) & Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS).

Investigator in a doubleblinded, randomized placebocontrolled study “Treatment of antipsychotic-associated obesity with a GLP-1-analogue” – The TAO study.

The study aims to find a medical treatment against the pro-metabolic side effects and weightgain observed in antipsychotic-treated patients.

The TAO study investigates the physiological effects of the GLP-1-analoque (exenatide) in obese, nondiabetic schizophrenia patients.

The primary endpoint is weight loss after 12 weeks treatment. Secondary endpoints comprise potential brain structural- and volumetric changes with hippocampus and striatum as regions of interest. Moreover changes in cerebral blood flow especially frontal cortex will be investigated and correlated to potential improvement in cognition.

See Curriculum Vitae (pdf, opens in a new tab)
See Curriculum Vitae (pdf, opens in a new tab)

See publications​​ (pdf, opens in a new tab)





Studying the correlation of Rem Sleep Behavior Disorder and Parkinsons Disease.

​​​Rem Sleep Behavior Disorder (RBD) is characterised by movement during REM sleep. During normal REM sleep the body is relaxed and rarely moves. Patients with RBD move more and verbalise more during there REM sleep, sometimes resulting in injuries to the patient or spouse.

It is suspected that some patients with RBD have a higher risk of developing Parkinsons Disease. In patients with Parkinsons Disease movement during REM sleep is common.

We want to establish the connection between RBD and Parkinsons Disease.

Patients diagnosed with RBD and with PD will undergo night-time measurements to establish the level of movement during the night. The night-time measurements are done by the Danish Center for Sleep Medicine. To differentiate RBD patients at risk of developing Parkinsons Disease from RBD patients that are not at risk of developing Parkinsons disease want to use MRI to establish both structural changes and diffusion tension imaging changes.

See Curriculum Vitae​ (pdf, opens in a new tab)







Affiliated to the Functional Imaging Unit via the Center of Neuropsychiatric Schizophrenia Research and Psychiatric Center Glostrup.

Currently involved in MR investigations of schizophrenia, including studies of experimentally induced non-paranoid psycosis by ketamine-infusion. Methods include MRS and ASL.

See Curriculum Vitae​ (pdf, opens in a new tab)



Stig P. Cramer - MD., Ph.D
My primary field of work is T1-weighted perfusion MRI in multiple sclerosis (MS) in cooperation with The MS clinic, Rigshospitalet. The aim of my current project is to measure the permeability of the blood-brain barrier in MS and healthy controls, in order to characterize the normal appearing white and grey matter as well as MS lesions.

See Curriculum Vitae​ (pdf, opens in a new tab)




Ph.D. student at the Department of Radiation Oncology, Rigshospitalet. The overall project examines the use of re-irraditaion for recurrent glioma (brain cancer) as well as the use of amino-acid PET (positron emission tomography) and dynamic MRI to improve radiotherapy for high-grade glioma.

Søren is collaborating with the Functional Imaging Unit on a prospective clinical protocol investigating changes in perfusion, diffusion and BOLD imaging during the course of radio- and chemotherapy for Glioblastoma multiforme, the most common and deadly form of brain cancer. The project is a joint venture between the FIU and the Depts. of Radiation Oncology and Oncology, Rigshospi​​talet.

See Curriculum Vitae​ (pdf, opens in a new tab)
Ulrich Lindberg - ​​M.Sc., Ph.D
​​​I am currently working with the concurrent recording of fMRI and EEG in different projects, using the higher spatio-temporal resolution that this method gives to investigate different hemodynamic/neuronal changes of the brain. My projects are funded by LUCENS and I am employed at the unit of functional imaging.

See Curriculum Vitae​ (pdf, opens in a new tab)



​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​