Peer reviewed papers

​Here is a complete list of publications from our lab including a few of Dr. Kornum and Dr. Gammeltofts earlier publications of relevance to our current research. 

(* shared first authorship)

EIF3G is associated with narcolepsy across ethnicities
Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, Levinson D, Han F, Gammeltoft S, Jennum P, Mignot E, Kornum BR (2015). European Journal of Human Genetics. 

Novel HLA loci confer risk and protection for narcolepsy 
Ollila HM*, Ravel JM*, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Jolanki O, Coquillard C, Högl B, Crowe C, Partinen M, Huang YS, Bourgin P, Vaarala O, Montplaisir J, Mack SJ, Mindrinos M, Fernandez-Vina M, Mignot E (2015). American Journal of Human Genetics. 

miRNA profiles in cerebrospinal fluid from patients with central hypersomnias
Holm A, Bang-Berthelsen CH, Knudsen S, Modvig S, Kornum BR, Gammeltoft S, Jennum P (2014). Journal of the Neurological Sciences.

Does autoreactivity have a role in narcolepsy? 
Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O. Lancet Neurology. 2014 Nov;13(11):1072-3. 

miRNA profiles in plasma from patients with sleep disorders reveal dysregulation of miRNAs in narcolepsy and other central hypersomnias
Holm A, Bang-Berthelsen CH, Knudsen S, Kornum BR, Modvig S, Jennum P, Gammeltoft S. Sleep. 2014 Sep 1;37(9):1525-33.

Narcolepsy as an autoimmune disease: the role of H1N1 vaccination and natural infection 
​Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O (2014). Lancet Neurology. 13(6):600-13.

ImmunoChip study implicates antigen presentation to T-cells in narcolepsy 
Faraco J*, Lin L*, Kornum BR, Kenny EE, Trynka G, Einen M, Rico TJ, Lichtner P, Dauvilliers Y, Arnulf I, Lecendreux M, Javidi S, Geisler P, Mayer G, Pizza F, Poli P, Plazzi G, Overeem S, Lammers GL, Kemlink D, Sonka K, Nevsimalova S, Rouleau G, Desautels A, Montplaisir J, Frauscher B, Ehrmann L, Högl B, Jennum P, Bourgin P, Peraita-Adrados P, Iranzo A, Bassetti C, Chen WM, Concannon P, Thompson SD, Damotte V, Fontain B, Breban M, Gieger C, Klopp N, Deloukas P, Wijmenga C, Hallmayer J, Onengut-Gumuscu S, Rich SS, Winkelmann J, Mignot E. PLoS genetics . 2013 Feb;9(2):e1003270.

Association mellem narkolepsi og H1N1-influenza
Kornum BR, Knudsen S, Gammeltoft S, Jennum P. Ugeskrift for Læger. 2013 175:815.

Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy 
Klein AB, Jennum P, Knudsen S, Gammeltoft S, Mikkelsen JD. Neurosci Lett. 2013 Jun 7;544:31-5.

Hypocretin deficiency develops during onset of human narcolepsy with cataplexy
Savvidou A, Knudsen S, Olsson-Engman M, Gammeltoft S, Jennum P, Palm L. Sleep. 2013 Jan 1;36(1):147-8.

Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy
Sorensen GL, Knudsen S, Petersen ER, Kempfner J, Gammeltoft S, Sorensen HB, Jennum P. Sleep. 2013 Jan 1;36(1):91-8. 

Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy
Andlauer O, Moore H 4th, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E. Sleep. 2012 35:1247-55. 

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Winkelmann J, Lin L, Schormair B, Kornum BR, Faraco J, Plazzi G, Melberg A, Cornelio F, Urban AE, Pizza F, Poli F, Grubert F, Wieland T, Graf E, Hallmayer J, Strom TM, Mignot E. Hum Mol Genet. 2012 21:2205-10

Early IVIG treatment has no effect on post-H1N1 narcolepsy phenotype or hypocretin deficiency
Knudsen S, Biering-Sørensen B, Kornum BR, Petersen ER, Ibsen JD, Gammeltoft S, Mignot E,  Jennum PJ. Neurology. 2012 79:102-3.

DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status
Weiner Lachmi K, Lin L, Kornum BR, Rico T, Lo B, Aran A, Mignot E. Hum Immunol. 2012 73:405-10.

Candidate biomarker verification: Critical examination of a serum protein pattern for human colorectal cancer
Albrethsen J, Bøgebo R, Møller CH, Olsen JA, Raskov HH, Gammeltoft S. Proteomics Clin Appl. 2012 Apr;6(3-4):182-9

Narcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain
Kornum BR, Faraco, J, Mignot E. Curr. Opin. Neurobio. 2011 21:897-903.

Common variants in P2RY11 are associated with narcolepsy
Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Nat. Genet. 2011 43:66-71.

Probing protein phosphatase substrate binding: affinity pull-down of ILKAP phosphatase 2C with phosphopeptides
Højlys-Larsen KB, Sørensen KK, Jensen KJ, Gammeltoft S. Mol Biosyst. 2012 Apr;8(5):1452-60. 

Intravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexy
Knudsen S, Mikkelsen JD, Bang B, Gammeltoft S, Jennum PJ. Neuropediatrics. 2010 Oct;41(5):217-22.

Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population
Knudsen S, Jennum PJ, Alving J, Sheikh SP, Gammeltoft S. Sleep. 2010 Feb;33(2):169-76.

Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
Knudsen S, Gammeltoft S, Jennum PJ. Brain. 2010 Feb;133(Pt 2):568-79. 

Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain
Kornum BR*, Stott SR*, Mattsson B, Wisman L, Ettrup A, Hermening S, Knudsen GM, Kirik D. Exp Neurol. 2010 222:70-85.

Responsible editor