Calcium and phosphate metabolic and calcium receptor disorders in uremia includingparathyreoidea regulation, klotho, FGF-23 and vitamin D.
Parathyroid klotho and FGF in uremia (PhD project)
Na+/K+, ATP-ase in parathyroids
Epigenetics of secondary hyperparathyroidism
Role of MicroRNA in secondary hyperparathyroidism
Chronic uremia, diabetes and metabolic disorders including chronic kidney disease as a cardiovascular risk factor: pathophysiology, biomarkers and intervention. Inter-individual differences in the vascular gene (with micro-arrays) and protein (mass spectometry) expression. Patterns with effect on the cardiovascular risk. The molecular effect of uremia on arterial cells in animal models and cell cultures.
Incretin hormones in chronic uremia; secretion, elimination, effect and clinical potential (PhD project. )
Polycystic kidney disease (PhD project)
Inhibition of aldosterone in chronic renal disease. (PhD project)
Prevention of progression to uremia and uremia-related cardiovascular disease
Chronic kidney disease as a cardiovascular risk factor: pathophysiology, biomarkers and intervention. Inter-individual differences in the vascular gene (with micro-arrays) and protein (mass spectometry) expression. Patterns with effect on the cardiovascular risk. The molecular effect of uremia on arterial cells in animal models and cell cultures. Scientific collaboration between research departments and centres (six PhD projects).
Study of heart and renal protection (SHARP). Multinational multicentre study.
Vascular function as estimated by measurements of endothelial-dependent flow-mediated (FMD) and endothelial-independent nitroglycerin-induced dilation (NID) of the brachial artery together with plasma markers of endothelial dysfunction and cardiovascular risk in various clinical disease conditions.
Continuous subcutaneous glucose monitoring in diabetic hemodialysis patients.
Establishment of a cohort of patients with chronic kidney disease in order to test novel and classical biomarkers for prediction of incident cardiovascular disease.
Baro reflexes in kidney disease.
J. S. Iversen
The potassium-stimulated aldosterone secretion in relation to hypertensive states.
The effect of aldosterone on chronic renal insufficiency after kidney transplantation.
Renal transplantation and immunosuppression.
S. S. Sørensen
Infectious complications after renal transplantation.
S. S. Sørensen
Immunological aspect of renal transplantation.
S. S. Sørensen
Acute and chronic dialyses
Removal of protein-bound uremic toxins by modified plasma separation and adsorption.
M. B. Damholt
PD-One; a multicentric. parallel, controlled, randomized, single blind clinical evaluation of new low sodium peritoneal dialysis solution on patients with hypertension treated with CAPD or APD.
T. Elung Jensen
EUVAS Pexivas study.
The role of plasma exchange in the treatment of ANCA associated vasculitis.
The effect of strength training, with or without intake of protein supplement in dialysis patients.
Ultraviolet light for sterilization of intraveneous catheters.
The IMPACT SHPT Study.
AV-fistulas, central stenoses and endovascular treatment.
Hemodialysis and continuous ScO2 monitoring.
The impact of changes in intrathoracic pressure during inspiration; impact on central blood volume and flow.