Current projects at the Department of Nephrology

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Calcium and phosphate metabolic and calcium receptor disorders in uremia includingparathyreoidea regulation, klotho, FGF-23 and vitamin D.

Parathyroid klotho and FGF in uremia (PhD project)
K. Olgaard

Parathyroid regulation
K. Olgaard

Na+/K+, ATP-ase in parathyroids
K. Olgaard

Epigenetics of secondary hyperparathyroidism
K. Olgaard

Role of MicroRNA in secondary hyperparathyroidism
K. Olgaard


Chronic uremia, diabetes and metabolic disorders including chronic kidney disease as a cardiovascular risk factor: pathophysiology, biomarkers and intervention. Inter-individual differences in the vascular gene (with micro-arrays) and protein (mass spectometry) expression. Patterns with effect on the cardiovascular risk. The molecular effect of uremia on arterial cells in animal models and cell cultures.

Incretin hormones in chronic uremia; secretion, elimination, effect and clinical potential (PhD project. )
B. Feldt-Rasmussen.

Polycystic kidney disease (PhD project)
B. Feldt-Rasmussen

Inhibition of aldosterone in chronic renal disease. (PhD project)
A-L. Kamper

Prevention of progression to uremia and uremia-related cardiovascular disease
A-L. Kamper.

Chronic kidney disease as a cardiovascular risk factor: pathophysiology, biomarkers and intervention. Inter-individual differences in the vascular gene (with micro-arrays) and protein (mass spectometry) expression. Patterns with effect on the cardiovascular risk. The molecular effect of uremia on arterial cells in animal models and cell cultures. Scientific collaboration between research departments and centres (six PhD projects).
B. Feldt-Rasmussen

Study of heart and renal protection (SHARP). Multinational multicentre study.
B. Feldt-Rasmussen

Vascular function as estimated by measurements of endothelial-dependent flow-mediated (FMD) and endothelial-independent nitroglycerin-induced dilation (NID) of the brachial artery together with plasma markers of endothelial dysfunction and cardiovascular risk in various clinical disease conditions.
P. Clausen

Continuous subcutaneous glucose monitoring in diabetic hemodialysis patients.
P. Clausen

Establishment of a cohort of patients with chronic kidney disease in order to test novel and classical biomarkers for prediction of incident cardiovascular disease.
S. Bro

Baro reflexes in kidney disease.
J. S. Iversen

The potassium-stimulated aldosterone secretion in relation to hypertensive states.
M. Egfjord


Transplant research

The effect of aldosterone on chronic renal insufficiency after kidney transplantation.
M. Egfjord

Renal transplantation and immunosuppression.
S. S. Sørensen

Infectious complications after renal transplantation.
S. S. Sørensen

Immunological aspect of renal transplantation.
S. S. Sørensen


Acute and chronic dialyses

Removal of protein-bound uremic toxins by modified plasma separation and adsorption.
M. B. Damholt

PD-One; a multicentric. parallel, controlled, randomized, single blind clinical evaluation of new low sodium peritoneal dialysis solution on patients with hypertension treated with CAPD or APD.
T. Elung Jensen

EUVAS  Pexivas study.
W. Szpirt

The role of plasma exchange in the treatment of ANCA associated vasculitis.
W. Szpirt

The effect of strength training, with or without intake of protein supplement in dialysis patients.
I. Eidemak

Ultraviolet light for sterilization of intraveneous catheters.
S. Ladefoged

The IMPACT SHPT Study.
S. Ladefoged

AV-fistulas, central stenoses and endovascular treatment.
S. Ladefoged

Hemodialysis and continuous ScO2 monitoring.
S. Ladefoged

The impact of changes in intrathoracic pressure during inspiration; impact on central blood volume and flow.
S. Ladefoged


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