Publikationer de seneste 5 år

Se laboratoriets publikationer fra de seneste 5 år.

(1) Nielsen BN, Aagaard G, Henneberg SW, Schmiegelow K, Hansen SH, Romsing J. Topical Morphine for Oral Mucositis in Children: Dose Finding and Absorption. J Pain Symptom Manage 2012 Jun 1.

(2) Mellgren K, Hedegaard CJ, Schmiegelow K, Muller K. Plasma cytokine profiles at diagnosis in pediatric patients with non-hodgkin lymphoma. J Pediatr Hematol Oncol 2012 May;34(4):271-5.

(3) Borst L, Wesolowska A, Joshi T, Borup R, Nielsen FC, Andersen MK, et al. Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia. Br J Haematol 2012 May;157(4):476-82.

(4) Hoffmann MH, Klausen TW, Boegsted M, Larsen SF, Schmitz A, Leinoe EB, et al. Clinical impact of leukemic blast heterogeneity at diagnosis in cytogenetic intermediate-risk acute myeloid leukemia. Cytometry B Clin Cytom 2012 May;82(3):123-31.

(5) Toft N, Schmiegelow K, Klausen TW, Birgens H. Adult acute lymphoblastic leukaemia in Denmark. A national population-based retrospective study on acute lymphoblastic leukaemia in Denmark 1998-2008. Br J Haematol 2012 Jan 11.

(6) Olsen M, Hjalgrim H, Melbye M, Madsen HO, Schmiegelow K. RT-PCR screening for ETV6-RUNX1-positive clones in cord blood from newborns in the Danish National Birth Cohort. J Pediatr Hematol Oncol 2012 May;34(4):301-3.

(7) Borst L, Buchard A, Rosthoj S, Wesolowska A, Wehner PS, Wesenberg F, et al. Gene dose effects of GSTM1, GSTT1 and GSTP1 polymorphisms on outcome in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2012 Jan;34(1):38-42.

(8) Jacobsen JH, Schmiegelow K, Nersting J. Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard. J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jan 15;881-882:115-8.

(9) de Fine LS, Schmidt LS, Rod NH, Schmiegelow K, Lahteenmaki PM, Kogner P, et al. Hepatoblastoma in the Nordic countries. Int J Cancer 2012 Aug 15;131(4):E555-E561.

(10) Rosthoj S, Keiding N, Schmiegelow K. Estimation of dynamic treatment strategies for maintenance therapy of children with acute lymphoblastic leukaemia: an application of history-adjusted marginal structural models. Stat Med 2012 Feb 28;31(5):470-88.

(11) Schmiegelow K, Lausten TU, Baruchel A, Pacheco CE, Pieters R, Pombo-de-Oliveira MS, et al. High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia. Leukemia 2012 Apr;26(4):675-81.

(12) Koch SV, Kejs AM, Engholm G, Moller H, Johansen C, Schmiegelow K. Marriage and divorce among childhood cancer survivors. J Pediatr Hematol Oncol 2011 Oct;33(7):500-5.

(13) Obro NF, Ryder LP, Madsen HO, Andersen MK, Lausen B, Hasle H, et al. Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods. Haematologica 2012 Jan;97(1):137-41.

(14) Nersting J, Borst L, Schmiegelow K. Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia. Clin Proteomics 2011;8(1):8.

(15) Levinsen M, Shabaneh D, Bohnstedt C, Harila-Saari A, Jonsson OG, Kanerva J, et al. Pneumocystis jiroveci pneumonia prophylaxis during maintenance therapy influences methotrexate/6-mercaptopurine dosing but not event-free survival for childhood acute lymphoblastic leukemia. Eur J Haematol 2012 Jan;88(1):78-86.

(16) Hansson H, Kjaergaard H, Schmiegelow K, Hallstrom I. Hospital-based home care for children with cancer: a qualitative exploration of family members' experiences in Denmark. Eur J Cancer Care (Engl ) 2012 Jan;21(1):59-66.

(17) Frandsen TL, Abrahamsson J, Lausen B, Vettenranta K, Heyman M, Behrentz M, et al. Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study. Br J Haematol 2011 Oct;155(2):244-7.

(18) Vestergaard TR, Juul A, Lausten-Thomsen U, Lausen B, Hjalgrim H, Kvist TK, et al. Duration of adrenal insufficiency during treatment for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2011 Aug;33(6):442-9.

(19) Gudrunardottir T, Sehested A, Juhler M, Grill J, Schmiegelow K. Cerebellar mutism: definitions, classification and grading of symptoms. Childs Nerv Syst 2011 Sep;27(9):1361-3.

(20) Schmiegelow K. Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries. Mediterr J Hematol Infect Dis 2011;3(1):e2011020.

(21) Obro NF, Marquart HV, Madsen HO, Ryder LP, Andersen MK, Lausen B, et al. Immunophenotype-defined sub-populations are common at diagnosis in childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 2011 Oct;25(10):1652-7.

(22) Hansson H, Hallstrom I, Kjaergaard H, Johansen C, Schmiegelow K. Hospital-based home care for children with cancer. Pediatr Blood Cancer 2011 Sep;57(3):369-77.

(23) Obro NF, Madsen HO, Ryder LP, Andersen MK, Schmiegelow K, Marquart HV. Approaches for cytogenetic and molecular analyses of small flow-sorted cell populations from childhood leukemia bone marrow samples. J Immunol Methods 2011 Jun 30;369(1-2):69-73.

(24) Borst L, Wallerek S, Dalhoff K, Rasmussen KK, Wesenberg F, Wehner PS, et al. The impact of CYP3A5*3 on risk and prognosis in childhood acute lymphoblastic leukemia. Eur J Haematol 2011 Jun;86(6):477-83.

(25) Wesolowska A, Dalgaard MD, Borst L, Gautier L, Bak M, Weinhold N, et al. Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia. Leukemia 2011 Jun;25(6):1001-6.

(26) Gudrunardottir T, Sehested A, Juhler M, Schmiegelow K. Cerebellar mutism: incidence, risk factors and prognosis. Childs Nerv Syst 2011 Apr;27(4):513-4.

(27) Lund B, Asberg A, Heyman M, Kanerva J, Harila-Saari A, Hasle H, et al. Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer 2011 Apr;56(4):551-9.

(28) Lund LW, Schmiegelow K, Rechnitzer C, Johansen C. A systematic review of studies on psychosocial late effects of childhood cancer: structures of society and methodological pitfalls may challenge the conclusions. Pediatr Blood Cancer 2011 Apr;56(4):532-43.

(29) Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther 2011 Mar;89(3):387-91.

(30) Molgaard-Hansen L, Mottonen M, Glosli H, Jonmundsson GK, Abrahamsson J, Hasle H. Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia. Br J Haematol 2011 Mar;152(5):623-30.

(31) Olsen M, Nielsen NK, Birkballe S, Hjalgrim H, Madsen HO, Schmiegelow K. Febrile infections in young children do not frequently induce translocation ETV6-RUNX1. Blood Cells Mol Dis 2011 Feb 15;46(2):175-6.

(32) Schmidt LS, Schmiegelow K, Lahteenmaki P, Trager C, Stokland T, Grell K, et al. Incidence of childhood central nervous system tumors in the Nordic countries. Pediatr Blood Cancer 2011 Jan;56(1):65-9.

(33) Vaitkeviciene G, Forestier E, Hellebostad M, Heyman M, Jonsson OG, Lahteenmaki PM, et al. High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies. Eur J Haematol 2011 Jan;86(1):38-46.

(34) Gudrunardottir T, Sehested A, Juhler M, Schmiegelow K. Cerebellar mutism: review of the literature. Childs Nerv Syst 2011 Mar;27(3):355-63.

(35) Lonnerholm G, Thorn I, Sundstrom C, Frost BM, Flaegstad T, Heyman M, et al. In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia. Leuk Res 2011 Apr;35(4):472-8.

(36) Caniza MA, Hunger SP, Schrauder A, Valsecchi MG, Pui CH, Masera G. The controversy of varicella vaccination in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 2012 Jan;58(1):12-6.

(37) Lausten-Thomsen U, Madsen HO, Vestergaard TR, Hjalgrim H, Nersting J, Schmiegelow K. Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates. Blood 2011 Jan 6;117(1):186-9.

(38) Schuz J, Schmidt LS, Kogner P, Lahteenmaki PM, Pal N, Stokland T, et al. Birth characteristics and Wilms tumors in children in the Nordic countries: a register-based case-control study. Int J Cancer 2011 May 1;128(9):2166-73.

(39) Hagenas I, Jorgensen N, Rechnitzer C, Sommer P, Holm M, Schmiegelow K, et al. Clinical and biochemical correlates of successful semen collection for cryopreservation from 12-18-year-old patients: a single-center study of 86 adolescents. Hum Reprod 2010 Aug;25(8):2031-8.

(40) Schmidt LS, Kamper-Jorgensen M, Schmiegelow K, Johansen C, Lahteenmaki P, Trager C, et al. Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth. Br J Cancer 2010 May 25;102(11):1670-5.

(41) Gregers J, Christensen IJ, Dalhoff K, Lausen B, Schroeder H, Rosthoej S, et al. The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number. Blood 2010 Jun 10;115(23):4671-7.

(42) Schmidt LS, Schuz J, Lahteenmaki P, Trager C, Stokland T, Gustafson G, et al. Fetal growth, preterm birth, neonatal stress and risk for CNS tumors in children: a Nordic population- and register-based case-control study. Cancer Epidemiol Biomarkers Prev 2010 Apr;19(4):1042-52.

(43) Schrappe M, Nachman J, Hunger S, Schmiegelow K, Conter V, Masera G, et al. 'Educational symposium on long-term results of large prospective clinical trials for childhood acute lymphoblastic leukemia (1985-2000)'. Leukemia 2010 Feb;24(2):253-4.

(44) Schmiegelow K, Heyman M, Gustafsson G, Lausen B, Wesenberg F, Kristinsson J, et al. The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse. Leukemia 2010 Apr;24(4):715-20.

(45) Lausten-Thomsen U, Madsen HO, Vestergaard TR, Hjalgrim H, Lando A, Schmiegelow K. Increased risk of ALL among premature infants is not explained by increased prevalence of pre-leukemic cell clones. Blood Cells Mol Dis 2010 Mar 15;44(3):188-90.

(46) Bruggemann M, Schrauder A, Raff T, Pfeifer H, Dworzak M, Ottmann OG, et al. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. Leukemia 2010 Mar;24(3):521-35.

(47) Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Soderhall S, et al. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 2010 Feb;24(2):345-54.

(48) Milani L, Lundmark A, Kiialainen A, Nordlund J, Flaegstad T, Forestier E, et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood 2010 Feb 11;115(6):1214-25.

(49) Nersting J, Schmiegelow K. Pharmacogenomics of methotrexate: moving towards individualized therapy. Pharmacogenomics 2009 Dec;10(12):1887-9.

(50) Hedeland RL, Hvidt K, Nersting J, Rosthoj S, Dalhoff K, Lausen B, et al. DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma. Cancer Chemother Pharmacol 2010 Aug;66(3):485-91.

(51) Biondi A, Baruchel A, Hunger S, Masera G, Schmiegelow K, Schrappe M, et al. The Eleventh International Childhood Acute Lymphoblastic Leukemia Workshop Report: Ponte di Legno, Italy, 6-7 May 2009. Leukemia 2009 Dec;23(12):2318-24.

(52) Nygaard U, Nielsen HS, Schmidt IM, Nysom K, Schmiegelow K, Sorensen JL. [Evaluation of trainee doctors' skills]. Ugeskr Laeger 2009 Sep 14;171(38):2742-5.

(53) Lausten-Thomsen U, Madsen HO, Schmiegelow K. Characterizing chromosomal break points of t(12;21)[ETV6-RUNX1]-positive leukaemia using multiple tiling PCR on whole-genome-amplified DNA. Leukemia 2010 Jan;24(1):203-5.

(54) Dahl S, Schmidt LS, Vestergaard T, Schuz J, Schmiegelow K. Allergy and the risk of childhood leukemia: a meta-analysis. Leukemia 2009 Dec;23(12):2300-4.

(55) Schmiegelow K, Heyman M, Kristinsson J, Mogensen UB, Rosthoj S, Vettenranta K, et al. Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. J Pediatr Hematol Oncol 2009 Jun;31(6):385-92.

(56) Schmiegelow K. Advances in individual prediction of methotrexate toxicity: a review. Br J Haematol 2009 Sep;146(5):489-503.

(57) Reimers TS, Mortensen EL, Nysom K, Schmiegelow K. Health-related quality of life in long-term survivors of childhood brain tumors. Pediatr Blood Cancer 2009 Dec;53(6):1086-91.

(58) Palle J, Frost BM, Petersson C, Hasle H, Hellebostad M, Kanerva J, et al. Thioguanine pharmacokinetics in induction therapy of children with acute myeloid leukemia. Anticancer Drugs 2009 Jan;20(1):7-14.

(59) Schmiegelow K, Al-Modhwahi I, Andersen MK, Behrendtz M, Forestier E, Hasle H, et al. Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Blood 2009 Jun 11;113(24):6077-84.

(60) Bohnstedt C, Taskinen M, Zeller B, Bjorgvinsdottir H, Hafsteinsdottir S, Schmiegelow K. Poor treatment compliance in children with down syndrome and acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2009 Jan;31(1):79-80.

(61) Schmidt LS, Grell K, Frederiksen K, Johansen C, Schmiegelow K, Schuz J. Seasonality of birth in children with central nervous system tumours in Denmark, 1970-2003. Br J Cancer 2009 Jan 13;100(1):185-7.

(62) Milani L, Lundmark A, Nordlund J, Kiialainen A, Flaegstad T, Jonmundsson G, et al. Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Res 2009 Jan;19(1):1-11.

(63) Davidsen ML, Dalhoff K, Schmiegelow K. Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2008 Nov;30(11):831-49.

(64) Schmiegelow K, Forestier E, Kristinsson J, Soderhall S, Vettenranta K, Weinshilboum R, et al. Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Leukemia 2009 Mar;23(3):557-64.

(65) Christensen LA, Dahlerup JF, Nielsen MJ, Fallingborg JF, Schmiegelow K. Azathioprine treatment during lactation. Aliment Pharmacol Ther 2008 Nov 15;28(10):1209-13.

(66) Schmiegelow K, Vestergaard T, Nielsen SM, Hjalgrim H. Etiology of common childhood acute lymphoblastic leukemia: the adrenal hypothesis. Leukemia 2008 Dec;22(12):2137-41.

(67) van Kooten Niekerk PB, Schmiegelow K, Schroeder H. Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate. Eur J Haematol 2008 Nov;81(5):391-8.

(68) Lonnerholm G, Nordgren A, Frost BM, Jonsson OG, Kanerva J, Nygaard R, et al. Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids. Leukemia 2009 Jan;23(1):209-12.

(69) Lausten-Thomsen U, Hjalgrim H, Marquart H, Lutterodt M, Petersen BL, Schmiegelow K. ETV6-RUNX1 transcript is not frequent in early human haematopoiesis. Eur J Haematol 2008 Aug;81(2):161-2.

(70) de Vries AC, Langerak AW, Verhaaf B, Niemeyer CM, Stary J, Schmiegelow K, et al. T-cell receptor Vbeta CDR3 oligoclonality frequently occurs in childhood refractory cytopenia (MDS-RC) and severe aplastic anemia. Leukemia 2008 Jun;22(6):1170-4.

(71) Olesen KM, Hansen SH, Sidenius U, Schmiegelow K. Determination of leukocyte DNA 6-thioguanine nucleotide levels by high-performance liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 2008 Mar 15;864(1-2):149-55.

(72) von SA, Hartmann R, Buhrer C, Fengler R, Janka-Schaub G, Reiter A, et al. High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia. Blood 2008 Mar 1;111(5):2573-80.

(73) Yenson PR, Forrest D, Schmiegelow K, Dalal BI. Azathioprine-associated acute myeloid leukemia in a patient with Crohn's disease and thiopurine S-methyltransferase deficiency. Am J Hematol 2008 Jan;83(1):80-3.

(74) Kamper-Jorgensen M, Woodward A, Wohlfahrt J, Benn CS, Simonsen J, Hjalgrim H, et al. Childcare in the first 2 years of life reduces the risk of childhood acute lymphoblastic leukemia. Leukemia 2008 Jan;22(1):189-93.