Christian von Buchwald

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Klinikprofessor, overlæge, dr. med


Primære forskn​ing​​sområder

Christian von Buchwald har bred forskningserfaring inden for otorhinolaryngologien og hoved-halscancer. 

Aktuelt pågår stort demografisk, klinisk og molekylært øst-dansk hoved-halscancer studie omhandlende relationen til Human Papillomavirus, som mulig forklaring på den kraftige stigning i de senere år antallet af cancer i mundsvælget.

Stamcellers rolle i metatstaseringsprocessen for hoved-halscancer undersøges. Kirurgisk udvikling med fokus på minimal invasiv kirurgi  samt kirurgisk oplæring dækker over implementering og videreudvikling af navigationskirurgi i form af avanceret endoskopisk kirurgi i bihuler og kraniekassens bund, sentinel node biopsy (SNB) ved mundhulecancer (indgår i den europæiske protokol, SENT) samt robotkirurgi i behandling af cancer i mundsvælget (i samarbejde med University of Penn) det første ØNH-center i Europa med egen robot.

Christian von Buchwald er vært for 2 årlige internationale kirurgikurser (se entcopenhagen.dk), som siden 2001 afholdes på Panum. Der er prægraduat etableret udveksling med Harvard Medical School, Boston, samt med Macquarie University, Sydney. Postgraduat samarbejdes der med universitetsafdelinger i England og HongKong.

Sammen med CEKU studeres evidensbaseret kirurgisk oplæring. Inden for rhinologien gøres flerdisciplinære studierr i sammenhængen mellem almene inflammatoriske lidelser i øvre og nedre luftveje ("United airways"). Parallelt med dette klarlægges bihulernes vigtige rolle ved de mere sjældne, genetisk betingede sygdomme, cystisk fibrose og primær ciliedyskinesi.


Publikatione​​r

  • Ciofu, O , Johansen, HK , Aanaes, K , Wassermann, T , Alhede, M , von Buchwald, C & Høiby, N 2013, ' P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs ' Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society ., http://dx.doi.org/10.1016/j.jcf.2013.02.004
  • Jensdottir, T , von Buchwald, C , Nauntofte, B , Hansen, HS & Jensen, AB 2013, ' Saliva in relation to dental erosion before and after radiotherapy ' Acta Odontologica Scandinavica , vol 71, nr. 3-4, s. 1008., http://dx.doi.org/10.3109/00016357.2012.741704
  • Jensdóttir, T , Jensen, AB , Nauntofte, B & von Buchwald, C 2013, Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva HK20080104449 20080422 .
  • Jensen, DH , Oliveri, RS , Fischer-Nielsen, A , Trojahn-Kølle, S-F , Specht, L , Jensen, AB & von Buchwald, C 2013, ' Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies ' Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology .
  • Hansen, SK, Rau, MH , Johansen, HK , Ciofu, O , Jelsbak, L, Yang, L, Folkesson, A, Jarmer, HØ , Aanæs, K , von Buchwald, C , Høiby, N & Molin, S 2012, ' Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection ' I S M E Journal , vol 6, nr. 1, s. 31-45., http://dx.doi.org/10.1038/ismej.2011.83, http://dx.doi.org/http://dx.doi.org/10.1038/ismej.2011.83
  • Holten-Andersen, L , Thaysen-Andersen, M , Jensen, SB , von Buchwald, C , Højrup, P , Offenberg, HK , Nielsen, HJ , Brünner, N , Nauntofte, B & Reibel, J 2011, ' Salivary tissue inhibitor of metalloproteinases-1 localization and glycosylation profile analysis ' A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica , vol 119, nr. 11, s. 741-749., http://dx.doi.org/10.1111/j.1600-0463.2011.02796.x
  • Johansen, HK , Aanaes, K , Pressler, T , Nielsen, KG , Fisker, J , Skov, M , Høiby, N & von Buchwald, C 2012, ' Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response ' Journal of Cystic Fibrosis , vol 11, nr. 6, s. 525-531., http://dx.doi.org/10.1016/j.jcf.2012.04.011
  • Lajer, CB, Garnæs, E , Friis-Hansen, LJ , Norrild, B , Therkildsen, MH , Glud, M , Rossing, M , Lajer, H , Svane, D , Skotte, L , Specht, L , von Buchwald, C & Nielsen, FC 2012, ' The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer ' B J C , vol 106, s. 1526-1534., http://dx.doi.org/10.1038/bjc.2012.109
  • Jensdóttir, T , Jensen, AB , Nauntofte, B & von Buchwald, C 2011, Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva EP1773453-B1.
  • Jensdóttir, T , Jensen, AB , Nauntofte, B & von Buchwald, C 2011, Acidic solid oral compositions without erosive potential in saliva and method for reduction of erosive potential in saliva IN246671-B.
  • Jensen, AB , Jensdóttir, T , Nauntofte, B & von Buchwald, C 2011, Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva CN101060888-B.
  • Junker, N , Andersen, MH , Wenandy, L , Dombernowsky, SL , Kiss, K , Sørensen, CH , Therkildsen, MH , Von Buchwald, C , Andersen, E , Straten, PT & Svane, IM 2011, ' Bimodal ex vivo expansion of T cells from patients with head and neck squamous cell carcinoma: a prerequisite for adoptive cell transfer ' Cytotherapy , vol 13, nr. 7, s. 822-34., http://dx.doi.org/10.3109/14653249.2011.563291
  • Lajer, CB , Nielsen, FC , Friis-Hansen, L , Norrild, B , Borup, R, Garnæs, E, Rossing, M , Specht, L , Therkildsen, MH , Nauntofte, B , Dabelsteen, S & von Buchwald, C 2011, ' Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study ' British Journal of Cancer Management , vol 104, nr. 5, s. 830-40., http://dx.doi.org/10.1038/bjc.2011.29
  • Aanaes, K , Kristensen, E , Ralfkiær, EM , von Buchwald, C , Specht, L , Aanaes, K , Kristensen, E , Ralfkiaer, EM , von Buchwald, C & Specht, L 2010, ' Improved prognosis for localized malignant lymphomas of the head and neck ' Acta Oto-Laryngologica , vol 130, nr. 5, s. 626-31., http://dx.doi.org/10.3109/00016480903311229, http://dx.doi.org/http://dx.doi.org/10.3109/00016480903311229
  • Jensdottir, T , Buchwald, C , Nauntofte, B , Hansen, HS & Bardow, A 2010, ' Erosive potential of calcium-modified acidic candies in irradiated dry mouth patients ' Oral Health & Preventive Dentistry , vol 8, nr. 2, s. 173-8.
  • Thode, C , Bilde, A , von Buchwald, C & Dabelsteen, E 2010, ' TP53 mutations in clinically normal mucosa adjacent to oral carcinomas ' Journal of Oral Pathology & Medicine , vol 39, nr. 9, s. 662-6., http://dx.doi.org/10.1111/j.1600-0714.2010.00916.x
  • Agger, A , von Buchwald, C , Madsen, AR, Yde, J, Lesnikova, I, Christensen, CB, Foghsgaard, S, Christensen, TB, Hansen, HS, Larsen, S , Bentzen, J , Andersen, E , Andersen, L, Grau, C, Agger, A, Buchwald, CV, Madsen, AR, Yde, J, Lesnikova, I, Christensen, C , Foghsgaard, S , Christensen, TB, Hansen, HS, Larsen, S, Bentzen, JD, Andersen, E, Andersen, L & Grau, C 2009, ' Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA ' Head & Neck (Print Edition) , vol 31, nr. 12, s. 1593-9., http://dx.doi.org/10.1002/hed.21132, http://dx.doi.org/http://dx.doi.org/10.1002/hed.21132
  • Bilde, A , Buchwald, CV , Dabelsteen, E , Therkildsen, MH & Dabelsteen, S 2009, ' Molecular markers in the surgical margin of oral carcinomas ' Journal of Oral Pathology & Medicine , vol 38, nr. 1, s. 72-78.
  • Jensdóttir, T , Buchwald, CV , Nauntofte, B & Jensen, AB 2009, Acidic solid oral compositions without erosive potential in saliva and method for determining erosive potential in saliva AU2005263337-B2.
  • Lajer, C , Buchwald, C , Nauntofte, B , Specht, L , Bardow, A , Jensdottir, T , Lajer, C, Buchwald, C, Nauntofte, B , Specht, L , Jensen, AB & Jensdottir, T 2009, ' Erosive potential of saliva stimulating tablets with and without fluoride in irradiated head and neck cancer patients ' Radiotherapy & Oncology , vol 93, nr. 3, s. 534-8., http://dx.doi.org/10.1016/j.radonc.2009.06.028, http://dx.doi.org/http://dx.doi.org/10.1016/j.radonc.2009.06.028
  • Bilde, A , von Buchwald, C , Therkildsen, MH , Mortensen, J , Kirkegaard, J , Charabi, B , Specht, L , Bilde, A , von Buchwald, C , Therkildsen, MH , Mortensen, J , Kirkegaard, J , Charabi, B & Specht, L 2008, ' Need for intensive histopathologic analysis to determine lymph node metastases when using sentinel node biopsy in oral cancer ' Laryngoscope , vol 118, nr. 3, s. 408-14., http://dx.doi.org/10.1097/MLG.0b013e31815d8e15, http://dx.doi.org/http://dx.doi.org/10.1097/MLG.0b013e31815d8e15
  • Lajer, CB , Jensdóttir, T , Nauntofte, B , Buchwald, CV & Jensen, AB 2008, ' The erosive potential of saliva-stimulating tablets with and without fluoride ' Journal of Dental Research , nr. Spec Issue B, s. 1588.
  • Marchal, F, Chossegros, C, Faure, F, Delas, B, Bizeau, A, Mortensen, B, Schaitkin, B , Buchwald, C , Cenjor, C, Yu, C, Campisi, D, Eisele, D, Greger, D, Trikeriotis, D, Pabst, G, Kolenda, J, Hagemann, M, Tarabichi, M, Guntinas-Lichius, O, Homoe, P, Carrau, R, Irvine, R, Studer, R, Wang, S, Fischer, U, Van der Poorten, V, Saban, Y, Barki, G & Publié Sous l'Egide de la Société Européenne des Glandes Salivaires 2008, ' Lithiases et sténoses salivaires. Une classification pratique des pathologies non tumorales ' Revue de Stomatologie et de Chirurgie Maxillo-Faciale , vol 110, nr. 1, s. e1-4., http://dx.doi.org/10.1016/j.stomax.2008.10.002
  • Jensdóttir, T , Nauntofte, B , Buchwald, CV & Jensen, AB 2007, ' Effects of sucking acidic candy with and without calcium on saliva degree of saturation with respect to HAp and erosive potential ' Caries Research , vol 41, s. 68-73.
  • Sjö, NC , Von Buchwald, C , Cassonnet, P , Norrild, B , Prause, JU , Vinding, T & Heegaard, S 2007, ' Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series ' British Journal of Ophthalmology , vol 91, nr. 8, s. 1014-1015.
  • Sjö, NC , Von Buchwald, C , Prause, JU , Norrild, B , Vinding, T & Heegaard, S 2007, ' Human papillomavirus and pterygium. Is the virus a risk factor? ' British Journal of Ophthalmology , vol 91, nr. 8, s. 1016-1018.
  • Sjö, NC , von Buchwald, C , Cassonnet, P, Flamant, P , Heegaard, S , Norrild, B , Prause, JU & Orth, G 2007, ' Human papillomavirus: cause of epithelial lacrimal sac neoplasia? ' Acta Ophthalmologica Scandinavica , vol 85, nr. 5, s. 551-6., http://dx.doi.org/10.1111/j.1600-0420.2007.00893.x
  • Bilde, A , Von Buchwald, C , Mortensen, J , Marving, J , Hamilton Therkildsen, M , Kirkegaard, J , Charabi, B & Specht, L 2006, ' The role of SPECT-CT in the lymphoscintigraphic identification of sentinel nodes in patients with oral cancer ' Acta Oto-Laryngologica , vol 126, nr. 10, s. 1096-103., http://dx.doi.org/10.1080/00016480600794453
  • Bilde, A , von Buchwald, C , Johansen, J, Bastholt, L, Sørensen, JAHM, Marker, P, Krogdahl, A, Hansen, HS , Specht, L , Kirkegaard, J , Andersen, E , Bentzen, J , Hjort-Sørensen, C, Andersen, LJ, Nielsen, BA, Bundgaard, T, Overgaard, M, Grau, C & Danish Society for Head and Neck Oncology 2006, ' The Danish national guidelines for treatment of oral squamous cell carcinoma ' Acta Oncologica , vol 45, nr. 3, s. 294-9., http://dx.doi.org/10.1080/02841860600592998
  • ​Kragelund, C , Hansen, C , Pedersen, AML , Buchwald, CV , Nauntofte, B , Torpet, LA & Reibel, J 2006, ' The transcription and expression of drug metabolizing cytochrome P450- enzymes in human salivary glands. ' 13 th biennial meeting of the International Association of Oral Pathologists, Brisbane, Australien, 21/06/06 - 25/06/06

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