Ben Vainer, MD, PhD, DMSC, Professor of pathology, consultant pathologist
DIagnostic areas of interest: Development and implementation of digital methods in diagnostic and scientific pathology. Application of software algorithms for assessment of especially cancer biomarkers is tested and validated, including HER2, estrogen and progesterone receptors and Ki67 in breast cancer, PHH3 in sarcomas and sentinel node assessment in breast cancer and malignant melanoma as well as development and logistics regarding online second opinion/consultations and installation of digital home offices.
Professor Vainer’s research currently focuses on digital methods for automatic assessment of cancer biomarker expression and how to use digital methods in the routine pathology laboratory setting. Denmark is the optimal place for such research because of its nationwide pathology systems, allowing quick and effective exchange of patient information between pathologists and efficient information flow with for example persons registers and registers of hospital admissions.
Professor Vainer’s diagnostic areas include liver pathology and uropathology, especially prostate cancer and colorectal cancer, and main research fields involve these disease areas as well as development and implementation of digitalisation in pathology.
In prostate cancer, a close collaboration with Copenhagen Prostate Cancer Center, CPC, studies prostate cancer from an epidemiological viewpoint, based on the national pathology database, and expression of biomarkers for diagnosis and prognosis. In colorectal cancer, the 2selecT and Inditreat projects investigate chemo-responsiveness in tumour spheres made from the patient's own tumour tissue and studies how small tumours develop.
In addition, the group collaborated with research group at Rigshospitalet, University of Copenhagen and other hospitals of the region as well as groups in Sweden, Germany and UK in studies of the liver, urine organs and the use of digital methods in quantitation of tissue markers.
As initiator of the virtual microscopy project at The Faculty of Health and Medical Sciences at University of Copenhagen, Professor Vainer has contributed critically to the use of digital teaching methods in the medical curriculum, which has ultimately resulted in the total substitution of physical microscopes for computers in the Bachelor programmes at the medical school.
> CV - Ben Vainer
David Scheie, MD, PhD, Consultant neuropathologist
Diagnostic areas of interest: neuropathology, ophthalmic pathology and pathology of muscle diseases, including post mortem neuropathological examinations, and forensic cases. The neuropathology service includes examination of specimens from the neurosurgical department, mostly CNS tumors, but also resections from epilepsy surgery and other diseases in which diagnostic brain biopsies are needed.
Most muscle biopsies are from patients with inflammatory myopathies. Ophthalmic pathology consists of specimens from all ophthalmologists in Denmark, including uveal and conjunctival melanomas, retinoblastomas and specimens from all other eye diseases in which diagnostic histopathology is required.
Research areas of interest: molecular biological markers in CNS tumors, both in adults and children.
- 2014- present date: Consultant neuropathologist, Department of Pathology, Rigshospitalet, Copenhagen, Denmark
- 2004- 2014: Consultant neuropathologist, Dept. of pathology, Rikshospitalet, Oslo University Hospital, Norway
- 2000- 2004: Trainee in general pathology and neuropathology , Dept. of pathology, Rikshospitalet, Oslo University Hospital, Norway
- 1999- 2000: Medical practitioner in the Norwegian Army (national service)
- 1997- 1999: Trainee in general pathology, Dept. of pathology, Rikshospitalet. Oslo University Hospital, Norway
- 1995- 1997: House officer at Lillehammer Hospital and Skjåk county, Norway
Education and training:
February 2015: Clinical observership in neuropathology, MD Anderson Cancer Center, Houston, Texas
February 2012: University of Oslo, Norway, PhD dissertation. Title of thesis: ”1p/19q-loss in oligodendroglial tumours – methodological, histological, radiological and clinical aspects”.
2004: Norwegian board certification in pathology
1995: University of Bergen. Cand.med. (MD).
Eva Løbner Lund, MD, PhD, Consultant neuropathologist
Diagnostic areas of interest: Neuropathology, ophtalmic pathology and pathology of peripheral nerves, including postmortem neuropathological examinations of neurodegenerative diseases.
The neuropathology service includes examination of specimens from the neurosurgical department, mostly CNS tumors, but also resections from epilepsy surgery and other diseases in which diagnostic brain biopsies are needed.
Peripheral nerve examination includes peripheral nerve biopsies and evaluation of small fiber neuropathy in skin biopsies from the neurological department.
Ophthalmic pathology consists of specimens from all ophthalmologists in Denmark, including uveal and conjunctival melanomas, retinoblastomas and specimens from all other eye diseases in which diagnostic histopathology is required.
Post mortem neuropathological examinations include suspected Creutzfeldt-Jakob´s disease cases from all of Denmark and forensic cases.
Research areas of interest: Inflammatory microenvironment in neurodegenerative diseases and tumors, with special focus on Creutzfeldt-Jakob’s disease.
- Consultant neuropathologist, Department of Pathology, Rigshospitalet, Copenhagen, Denmark
- Clinical associate professor, University of Copenhagen
- President, Danish Pathology Society
Previous work experience:
- 2012 – 2014: Staff Specialist at Laboratory of Neuropathology, Department of Pathology, Rigshospitalet, Copenhagen
- 2011: Staff specialist in general pathology, Bispebjerg hospital, Copenhagen.
- 2006 – 2011: Specialist education in general pathology. Pathology departments at Bispebjerg Hospital, Rigshospitalet and Hillerød Hospital.
- 1996 – 2006: Research assistant, Ph.d.-student, assistant professor and associate professor at Dept. of Molecular Pathology, University of Copenhagen. Research focus on tumor angiogenesis and tumor microenvironment in glioblastoma and lung cancer models
- 1990 – 1998: Hospital physician at departments of surgery, rheumatology, medicine and oncology.
Education and training:
• 2011: Danish board certification in pathology
• 2001: University of Copenhagen, PhD dissertation. Title of thesis: “Blood vessels in human tumor xenografts. Angiogenesis, adaptation to therapy and the role of the microenvironment.”
• 1990: Århus University: Cand. Med. (MD)
Karsten Buschard, Professor, MD, DMSc, DVSc
am team leader of the diabetes department at Bartholin institute, Department of pathology, Rigshospitalet. I am educated as an MD and after 6 years of clinical training, I have ever since worked in medical research where my main interest is to understand and prevent development of type 1 diabetes. As seen from my Curriculum Vitae I have suggested several new principles in this respect, which include rest of beta cells, intake of gluten-free diet and influence on the glycosphingolipid metabolism. Currently I am head of a research group of up to 10 dedicated persons.
Among specific research projects the gluten-free diet studies can be mentioned. In 1999 we published, as the first worldwide, that intake of gluten-free diet dramatically reduces the diabetes incidence in NOD mice. This has been confirmed in several other studies, and also in human type 1 diabetic patients a better remission period can be obtained by giving this diet. Even some patients can come out of insulin treatment for 1-2 years. Among the mechanisms for these beneficial effects can be mentioned changes in the intestinal flora (more Akkermancia), less permeability of the intestinal barrier, less activity of some immune cells (natural killer cells, dendritic cells) and less activity of the beta cells.
> CV - Karsten Buschard
Laurits Juulskov Holm, MSc Biochemistry, PhD Student
Areas of interest: Molecular cell biology, lipid biology, diabetes, sphingolipids, GWAS, animal experimentation
Project description: Affiliated to the Bartholin Institute, Rigshosiptalet and the Copenhagen center for Glycomics, University of Copenhagen
I work with a type of sphingolipid called sulfatide which is present in the insulin producing islets of Langerhans where it is known to be involved in many aspects of cell biology.
The project is concentrated around understanding the role of sulfatide and other sphingolipid during the development of type 1 diabetes. This is done using human samples combined with mice experiments and cell cultures.
In the long term the aim is to prevent development of type 1 diabetes through modulation of sphingolipid metabolism.
CV - Laurits Juulskov Holm
Tina Zenia Jørgensen- PhD Student, Cand.scient. in Molecular Biomedicine
Affiliated to The Bartholin Instiute, Rigshospitalet, Denmark.
Development of type 1 diabetes depends on many environmental factors including gluten. I am studying the immunological mechanisms underlying the preventive effects of gluten-free diet administered to the diabetes-prone NOD mouse strain.
Expertise: Mouse studies, Flow cytometry, in vitro cultivation and proliferation
CV - Tina Zenia Jørgensen
Vera Timmermans-Wielenga, DMSc, Pathologist, Head of dept. of Pathology
Areas of interest: Medical doctor, Pathologist, MD PhD. Head of Pathology Dept, Rigshospitalet.
Expertise and objectives: Strategic leadership within Public Health with focus on professionalism, content & continuing education, innovation & efficiency, building alliances & shearing of knowledge.
The Pathology Department at Rigshospitalet, delivers diagnostic expertise according to international standards to Denmarks most specialised hospital and is characterised by a thriving academic research environment, integrated in efficient patient care within all pathology subspecialties.
Personal continuing education & development: Ongoing courses on leadership & management at a.o. INSEAD and Harvard Medical School
Current activities: We are currently organizing a pathology course together with MD Anderson Pathology:
We expect the department to deliver all diagnostics digitally soon. The laboratory is already digitized with computer support of every step of the specimen analysis. throughput. In addition, we engage three consultant pathologists performing digital diagnostics, of which two pathologist from abroad.
The department's is to be fully digitized on all areas within the coming two years.
CV - Vera Timmermans-Wielenga
Publications under Wielenga
> Publications under Timmermans-Wielenga