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The laboratory employs 15 people, including 2 gyneacologists, 1 post doc, 1 laboratory technician, 5 PhD students and 4 Master students.
Claus Yding Andersen ProfessorClaus Yding Andersen has worked with reproductive biology and assisted reproduction since the early 1980’ties and was part of the team that started in vitro fertilization as a treatment in Denmark. He is now heading the laboratory and holds a MSc degree from the Danish Technical University and a DMSc degree from Copenhagen University. He has published more than 200 scientific papers, gives many internationals presentations and is an often requested teacher. He currently serves on several editorial and scientific boards. His main scientific interests include ovarian endocrinology and physiology, fertility preservation, gonadal development and human embryonic stem cells. Clinically the laboratory undertakes cryopreservation of ovarian and testicular tissue for fertility preservation from patients at risk of becoming infertile due to the treatment of a severe disease. In Denmark this service has been centralised to our laboratory, which is the only laboratory performing these procedures.
Marjo Westerdahl Bioanalyst
Marjo Westerdahl is a bioanalyst who joined the Laboratory of Reproductive Biology in 2007. She graduated in Eindhoven, Holland, in 1982. From 1988 to 1995 she settled in Norway, where she worked at Section for Clinical Pharmacology and Toxicology, Center of Biotechnology, and Nycomed Pharma. In 1995 she continued her career at the Finsen Laboratory, Rigshospitalet, Denmark, where she obtained extensive knowledge of sterile work, cell culture and biochemical analysis, including hormone assays. At LRB Marjo has specialised in stem cell culture, ELISA and cryopreservation of ovarian tissue. She is also responsible for the training of new students in the laboratory.
Kirsten Tryde Schmidt Gyneacologist
Kirsten Tryde Schmidt is a gynaecologist at the Fertility Clinic, University Hospital of Copenhagen (Rigshospitalet), where she works as a fertility specialist with IVF and also is clinically responsible for the fertility preservation programme, including counselling and choosing patients eligible for cryopreservation of ovarian tissue. She earned her university degree in 1992 and specialized in gynaecology and obstetrics in 2008. In 2005 she achieved a PhD degree from the University of Copenhagen with the thesis "Cryopreservation of ovarian tissue from girls and women prior of treatment of a malignant disease”. Kirsten is currently employed in a position between the Fertility Clinic and the Laboratory of Reproductive Biology.Her research focuses on fertility preservation in cancer patients.
Mikkel Rosendahl graduated from the Medical School at the University of Copenhagen in 2002. After an 18-month internship, he focused on his specialist training in gynaecology and obstetrics. In 2009, he defended his PhD thesis on preservation of fertility from the Laboratory of Reproductive Biology and the Fertility Clinic at Copenhagen University Hospital, Rigshospitalet.
Stine Gry Kristensen Post.doc.
Stine Gry Kristensen is a Post.doc. at the Laboratory of Reproductive Biology, which she joined in March 2009. She graduated in Biology from the University of Copenhagen in 2009 with a Master in cell and developmental biology, and obtained her PhD degree in June 2013. Her present work focuses on human follicle development and the regulatory mechanisms underlying early folliculogenesis. The Danish cryopreservation programme for ovarian tissue at LRB provides a unique opportunity to work with human ovarian tissue. In the first part of her PhD Stine has developed a method to isolate preantral human follicles from discarded medulla tissue, and this method enables her to study early follicular development and perform in vitro studies. Currently, Stine is developing a 3D culture system for preantral human follicles and investigating the effect of different gonadotropins and growth factors that possibly influence on follicle growth, survival and maturation in vitro.Stine is also course-coordinator of The Copenhagen Workshop on Cryopreservation of Ovarian Tissue.
Annette Klüver Jensen PhD Student
Annette Klüver Jensen graduated as a medical doctor from the University of Copenhagen in January 2010. She took her internship in a Department of Internal Medicine and in a General Practice. After completing her internship, she worked clinically one year in a Department of Abdominal Surgery and one year in a Department of Obstetrics and Gynaecology. In October 2013 she enrolled as a PhD-student where her research is focused on: 1) Follow-up on Danish children whom we, since 1999, have cryopreserved ovarian tissue on. 2) Follow-up on Danish women whom we have done autotransplantation of cryopreserved ovarian tissue on.
Tanni Borgbo PhD StudentTanni Borgbo started as a research assistant at LRB in February 2012 after graduating as M.Sc. in Molecular Biology from Aarhus University. In February 2013 she started her PhD project in collaboration between Aarhus University and LRB. In her PhD project, Tanni investigates how common genetic variations affect follicle development and hormone production, and how genetic variations may interfere with fertility treatment. The perspective of this study is to develop pharmacogenetic assays for a number of genes, which may interfere with the downstream signalling initiated by Follicle Stimulation Hormone (FSH).
Linn Salto Mamsen PhD Student
Linn Salto Mamsen completed her master in Human Biology from the University of Copenhagen at the Laboratory of Reproductive Biology in 2010. Her project evaluated whether maternal cigarette smoking during pregnancy affected the number of germ cells in the developing testes of the male embryo and foetus. The study found that the number of germ- and somatic cells was significantly reduced in testes exposed prenatally to cigarette smoke, and the same significant negative effect was found when exposed testes and ovaries were analyzed together. In 2011 Linn continues the studies on human germ cell development as a PhD student at the laboratory. These studies aim to clarify the mechanisms, on a genetic level, by which germ cell number is reduced by cigarette smoke. Furthermore, cell survival and cell proliferation rates are examined in culture studies in which toxic components found in cigarettes are added.
Janni Vikkelsø Jeppesen PhD Student
Janni Vikkelsø Jeppesen has been working at LRB since August 2010 after graduating as M.Sc. in Biochemistry from the University of Copenhagen. In June 2011 she started her PhD studies. Her work focus on characterization of human small antral follicles, obtained from human ovaries surgically removed for fertility preservation by cryopreservation. Small antral follicles visible on the surface of the ovary or exposed during preparation of the ovarian cortex are aspirated and used in this study. To characterize the small antral follicles, levels of testosterone, estradiol, progesterone, androstenedione, follistatin, activin A and AMH are measured in the follicular fluid and mRNA expressions of the FSH-receptor, LH-receptor, Androgen-receptor, Cyp19 (Aromatase), AMH and AMH-recpetor 2 from the corresponding granulosa cells are estimated using qRT-PCR. The perspective of this study is to get a better insight into the complex regulatory mechanisms controlling folliculo-genesis, especially at the small antral stage.
Maj Linea Vestergaard PhD Student
Maj Linea Vestergaard has been working at LRB since September 2010 after graduating as M.Sc. in Biology from the University of Copenhagen. Her Masters studies focused on the molecular aspects of cardiac development and at LRB she has continued this work by studying the differentiation of human embryonic stem cells (hESC) to cardiac muscle cells (cardiomyocytes). In 2011 Maj started her PhD studies which involve producing a reproducible protocol for cardiomyocyte differentiation with the parallel characterization of the differentiation process and the cardiomyocytes. The perspectives of this study is to create a continuous production of heart cells for basic scientific studies and possibly for screening drug candidates and test potential toxic chemical substances.
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