Tissue Typing Laboratory - Clinical Immunology

Scope of Care

• Clinical Immunology laboratory services for diagnoses and treatment of patients, research and development and education.
• Most investigations and functions of the Tissue Typing Laboratory are provided for all patients in Denmark and a minor part for all patients in East-Denmark.
• HLA class I and II typing and matching:
• Donor and recipient selection, screening and cross matching for solid organ transplanta-tion and bone marrow transplantation
• Diagnostic HLA typing in diseases
• Drug related HLA typing
• The East-Danish Bone Marrow donors Registry
• Pre- and post transplant monitoring for bone marrow transplantation:
• Immune competence
• Chimaerism
• Minimal residual disease (MRD)
• HPA platelet gene typing and anti-platelet antibody screening and specificity detection.
• Immunodeficiency: screening and diagnosis; monitoring of treatment; using:
• CD markers (flow cytometry)
• Lymphocyte stimulation
• MBL (Mannose-Binding Lectin): gene typing and serum concentration
• Complement functions
• Somatic hypermutation
• Leukaemia: diagnosis and monitoring of treatment; using:
• CD-markers
• Gene rearrangement (Ig, TCR)
• MRD using patient-specific gene-rearrangements
• Detection and quantification of translocation transcripts

The number of analyses in 2006 and evaluation of complexity are given at page 2

Staff in total:
75 (individuals)

40 Technologists (including the Chief technologist)
6 Medical doctors (2 seniors and 4 trainees)
3 Senior scientists
2 Post docs
8 Ph.d. Students
5 Master students
5 Office assistants
4 Service assistants

Quality-improvement projects/initiatives

• Continuing education program
• Continuing efforts to persuade authorities to provide adequate lab. facilities
• Continuing improvement of our IT program
• Continuing attempts to obtain the right information from clinicians, e.g. by improvement of our analysis requisition form
• Comprehensive external and internal proficiency testing programs for all accreditated areas
• ASHI (American Society for Histocompatibility and Immunogenetics) Accreditation (since 1994). Requires renewal annually.