Rigshospitalet houses nationally and internationally recognised research environments, ensuring establishment of the latest international clinical and research-related results.
The most important focus areas for research by the centres and departments are briefly described below:
-------------------------------------------------------- The Abdominal Centre
Department of Anaesthesia and OperationHuman circulatory physiologyMonitoring of central blood volumePeri-operative patho-physiologyCerebral blood flow and metabolismPost-operative pains after breast surgeryTargeted fluid therapyReduction of peri-operative loss of bloodDepartment of HepatologyTreatment of acute liver failurePatho-physiology in connection with liver failure and encephalopathyDevelopment of liver replacement therapyLiver gene expression of acute-phase reaction regarding effects of liver damageEndotoxin determined cholestasisTreatment of chronic hepatitis B and CHaemodynamic effects in connection with chronic liver diseaseTreatment of alcoholic hepatitis and hepatorenal syndromeIntensive Care Unit
Patho-physiology in connection with critical illnessHuman experimental models for critical illnessBrain patho-physiologyBlood supply and metabolism of the brainMuscle stimulation of critically ill patientsMarkers for haemostasisColonic barrier functionGenetic epidemiologyInhalation treatment of critically ill patients Department of Vascular Surgery
Secondary Prevention and pharmacological treatment of patients with peripheral arterial disesase (PAD)
Cerebral perfusion and carotid artery disease
Development of diagnostic ultrasound in patients with cerebrovascular disease and PAD
Endovascular treatment of abdominal and thoracic aortic aneurysms
Department of SurgeryGastrointestinal endocrinologyGastroenterologic cancersInflammatory intestinal diseasesOrgan transplantationsGastroenterologic endoscopySurgical children’s diseasesDepartment of Medical Gastroenterology
The patophysiological consequences of short bowel syndrome. Human experimental studies aiming to improve intestinal function in patients with intestinal insufficiency and failure. Treatment with intestinotrophic agents.
Studies of body composition and bone mineral density in patients with intestinal disorders.
Epidemiological cohort studies of complications in relation to enteral and parenteral nutrition.
Biological agents in the treatment of patients with inflammatory bowel disease.
Department of Nephrology & Endocrinology
Calciummetabolic disturbances in uremia
Uremia and atherosclerosis
Prevention of chronic uremia
Clinical & experimental transplantation
Post transplant diabetes and bone disease
Acute and chronic dialysis
Microalbuminuria/endothelial cell dysfunction.
Diabetes and endstage uremia
Diabetes and pregnancy
Growth hormone and uremia
Growth hormone and pituitary insufficiency
Pituitary gland and thyroid
Pituitary insufficiency and brain damage
Thyroid associated ophthalmopathy
Thyroid and quality of life
Evaluation of endocrine tests
Cytokines/milieu factors and endocrine function in vitro
Department of UrologyPhysiology and patho-physiology of the bladder and urethraMale infertilityUrological oncologyUrological symptoms after spinal cord injury-------------------------------------------------------- The Centre of Diagnostic Investigation
Infectious Hygiene UnitDevelopment of bacterial resistance to antibioticsQuality control of flexible endoscopesQuality control of haemodialysis apparatusNosocomial, gastrointestinal infectionsQuality control of respiratorsTyping of multi-resistant bacteriaSpread of MRSAClinical Physiology, Nuclear Medicine & PET
Molecular imagingPET and PET/CT in oncologyExamination of children Radioactive marking of stem cellsNuclear cardiology and neuro-endocrinologyNeuro PETExamination of the lungs, particularly mucociliary clearance and SPECTTreatment with radio-nuclides (local radiotherapy)Whole-body counting with regard to body composition and absorption of mineralsDepartment of Clinical Biochemistry Expression regulation and biologically active peptidesDiagnostics of disease genesVascular biologyTranscription factors in cell growth and differentiationTransgenic mice as disease modelsTransgenic mouse models for signal transduction pathwaysDisease mechanism in connection with leukaemiaNonsense-mediated mRNA decay: a genomic monitoring systemRNA biologyDepartment of Clinical PharmacologyClinical pharmacology: DNA repair and oxidative damage and ageing. Pharmaco-epidemiology.
Molecular biological markers for drug effects. Rational pharmaco-therapy.Quality control: Drug prescription, audit of bed-consuming departments. Register studies (Statistics Denmark drug database).Department of Clinical Immunology, Blood Bank
Recombinant antibodiesGenomic blood groupingErythrocyte chimerismImmune reconstitution after bone marrow transplantationCultivation and use of mesenchymal stem cellsCellular therapyOptimisation of massive blood transfusion treatmentImmunological aspects of HIV and malaria infectionsMolecular biological and animal experimental research in cytokinesDiagnostics of viral infections transmittable in connection with transfusionsDepartment of Clinical Immunology, Tissue Typing LaboratoryImmunogenetics in connection with infection, autoallergy and allergiesCharacterisation of immune defectsMolecular genetic and biological aspects regarding the adaptive immune systemMolecular genetic and biological aspects regarding the innate immune systemMolecular genetic and biological aspects regarding malignant haematological diseasesDepartment of Clinical MicrobiologyPathogenesis, prophylaxis and treatment of P. aeruginosa infection in cystic fibrosis patientsImmunology of parasitic diseases such as leishmaniasis and malaria as well as the development of drugsPathogenesis and immunology of Helicobacter pylori infectionDiagnostics and molecular biology of parvovirus B-19, RSV and the measles virusDiagnostics, epidemiology and organic aspects of Clostridium difficileDepartment of Pathology Clinical oncological pathologyExperimental pathology and molecular cancer therapyTransplantation pathology/immunology, including diabetesNeuro-degenerative diseasesReproduction/foetal pathologyDepartment of Diagnostic Radiology
Endoluminal UL sonography
Contrast agents and UL sonography in tumour characterisation
Image fusion: UL, CT, MR, PET
CT coronary arteriography
-------------------------------------------------------- The Finsen Centre
Copenhagen Muscle Research CentreCentral and peripheral regulation of muscle blood flowMuscle metabolismMuscle adaptation, including muscle-contraction-induced gene expressionMuscle B fat B brain interactionMuscle and inflammationDepartment of Infectious Diseases Experimental model of human sepsisHIV treatment, virology and immunologyInflammation and metabolismMalaria immunologyMeningitis patho-physiologyInfection immunologyStress immunologyAging, immunology TuberculosisCentre of Inflammation and Metabolism (CIM)Muscle - fat – brain interactionInflammation - metabolism interactionAging, inflammation and cognitive functionThe Finsen LaboratoryExperimental cancer research for clinical useExtra-cellular proteolysis in connection with cancer invasion and metastasisingBasic mechanisms and identification of molecules involved in these processes, development of new diagnostic and therapeutic methodsDepartment of Haematology
Alloreactivity, immune reconstitution, graft-versus-host disease, graft-versus-leukemia effect
Autologous stem cell transplantation, minimal residual disease
Molecular biology and cell biology of CD5+ B-cell malignancies
Innate immunity and myeloid cell maturation
Effects of bisphosphonates on cell cycle and apoptosis of myeloma cells
Genetic and epigenetic alterations in malignant lymphoma and MDS
FDG-PET for optimization of the treatment of malignant lymphoma
Pathogenesis of inherited MDS
Non-medical intervention as profylaxis against infections in neutropenic patients with AML
Institute for Inflammation Research (IIR)Gene expression (genechips)
Signal peptides (cytokines)
Complement and complement receptors, B- and T-lymphocyte functions
Receptors of the innate immune system (Toll-like receptors etc.)
Antigen presentation, dendritic cells, vaccination
Pathogenic mechanisms in infectious and immunoinflammatory diseases (fx. rheumatoid arthritis, osteoarthritis, inflammatory bowel diseases, allergies, arteriosclerosis, cancers).
Development of new therapies for immunoinflammatory diseases
Immunogenicity of biopharmaceuticals and monitoring treatments with
Department of Oncology
Clinical research trials of antineoplastic treatment modalities in patients with solid tumours.
Investigations of new antineoplastic drugs, including new targeted products, in the treatment of different solid tumours.
Development and investigations of new advanced technologies in high precision radiotherapy, including respiratory adapted radiotherapy, intensity modulated radiotherapy, and particle therapy.
Investigations of advanced imaging modalities for radiotherapy planning, in particular PET/CT-scans with FDG and other markers.
Development and investigations of molecular markers for selection of patients to different kinds of antineoplastic treatment.
Investigations of diagnostic tools in patients with solid tumours, including PET/CT-scans and molecular biology.
Targeted gene therapy for patients with small cell lung cancer.
Molecular biology and clinical investigations in patients with brain tumours.
Department of RheumatologyCohort studies of several rheumatology patient groups, including rheumatoid arthritis, systemic lupus erythematosus, anti-phopholipid syndrome, sclerodermi, neuro-sarcoidosis and Wegener’s granulomatosis.Research is primarily aimed at these cohorts in the form of clinical research supported by laboratory research with studies of various inflammatory and serologic biomarkers.Department of Radiation OncologySignificance of over-expression of the EGF receptor and a cancer-specific receptor (EGFRvIII) for the development and maintenance of the malignant phenotypeTranscriptional targeted gene therapy against small-cell lung cancer-------------------------------------------------------- The Heart Centre
Department of CardiologyIschaemic heart disease – clinically controlled studiesGene therapy and stem-cell therapy in myocardial ischaemiaGenetic molecular mechanisms behind heart hypertrophy and arrhythmiaHeart failure – clinically controlled studiesAtrial fibrillation and treatmentThe role of cell cycle in heart hypertrophyClinical genetic studies within cardiomyopathy and arrhithmiaResyncronisation therapyRight ventricular function in heart failureGenetic mechanisms in heart failureDepartment of Cardiothoracic SurgeryLung and heart transplantationValve-preserving heart surgerySurgical revascularisation without the use of a heart-lung machine as well as total arterial revascularisationExtra-corporal circulation (ECC).Heart Mate as a bridge to heart transplantationSurgery for pectus excavatus and mesothelioma
Randomised studies focusing on ECC, haemorrhage, thrombosis, PCI versus CABG
Department of Thoratic AnaesthesiologyHypothermia treatment after circulation stopReperfusion oedema after a single lung transplantationMechanical assist devices for patients with terminal heart failureThrombo-elastogram and bleeding mechanisms-------------------------------------------------------- The Centre of Head and Orthopaedics
Department of Anaesthesia
Postoperative cognitive dysfunction
Management of the difficult airway
Anaesthesia for obese patients
Neuromuscular blocking agents
Perioperative pulmonary dysfunction
Optimisation of perioperative use of blood products
Hyperbaric oxygen therapy
Department of Occupational- and Physiotherapy
Children and elitist sportsThe immune system and physical activityErgotherapy and physiotherapyBack disordersNutrition and training in connection with diseasesRehabilitation of muscular-skeletal disordersHyper mobility syndromesRare congenital disabilitiesLymphodeameaDepartment of Plastic Surgery and Burn UnitSurgical and adjuvant vaccination treatment of malignant melanomaDevelopment of diagnostic procedures in stage grouping of malignant melanomaGenetic reasons and new surgery procedures in children with cleft lip and palatePrimary breast reconstruction in connection with breast cancer treatmentPhysiology of circulation in tissue flapsPressure sore treatment in paraplegic patientsEpidemiology, prevention and instrumental diagnosis of burnsReduction of bleeding in burn surgeryDepartment of Breast Surgery
Epidemiologic, clinical and prognostic aspects in breast cancer
Diagnostics and treatment of symptoms from the breasts
Optimisation of acute and chronic pain management in breast cancer treatment
Optimasation of the sentinel lymph node technique
Screening of psycosocial distress in women with breast cancer
Fast track surgery for breast cancer
Department of Orthopaedic SurgeryBone density studies in relation to endo prothesis and after spinal surgeryX-ray stereophotometric analysesAngiotensin genotype and spinal surgery. Significance for regional blood flow and post-operative course.Effects of cytokines and other signal molecules on insulin signalling in primary human muscle cell culturesDevelopment and studies of a new minimal invasive anterior approach in primary total hip alloplastyDepartment of Dental and Maxilliofacial Surgery, Odontology Knowledge Centre, 3D LaboratoryMaxillofacial and dental traumatologyDental and bone transplantationsImplantsCorrective/orthognathic oral suregeryOsseo-distractionGrowth factorsOral medicinePrecancerous diseasesHyperbaric oxygen treatmentNerve regeneration3D technologyVisualisation, analysis, modelling and simulation of multi-dimensional medical data, with application within medicine and odontologyEye Clinic Age-related macular-degeneration epidemiology in Denmark and Greenland.Glaucoma, oxygen tension in the blind spotOncology, imagingDevelopmental defects, traumatology and reconstruction surgeryOrbital diseasesTreatment of retinovitreal diseasesTransplantation of retinal pigment epitheliumDepartment of Otorhinolaryngology, Head & Neck Surgery
Image guided surgery
Diagnostic biomarkers in tumour tissue, blood and saliva in oral and pharyngeal planocellular cancers
Sentinel Node Biopsy studies in patients with oral planocellular cancers
The presence of micro-metastasis in sentinel and non-sentinel lymph nodes in oral planocellular cancers
The presence of human papillomavirus in connection with head and throat cancers
"The Visible Ear Project"
Screening of the hearing in new-borns
Inflammation of the middle ear in Greenland
Chronic sinusitis and link to pulmonary diseases
Significance of sinusitis in cystic fibrosis patients
-------------------------------------------------------- The Juliane Marie Centre
Department of Growth and ReproductionCarcinoma in situ of the testis and testicular cancerTesticle development and differentiation of germinal cellsMale infertility and hypogonadismEndocrine disruptersIntersex conditionsPubertyGrowth and developmentIntra-uterine growth and placental growth hormoneInsulin-like growth factorsEffect of hormone receptors on cell growth and differentiationTesticular Dysgenesis SyndromeDepartment of Anaesthesia and OperationPost-operative pain managementPain management for childrenDepartment of Surgical Pathophysiology Surgical pathophysiology focusing on perioperative fluid treatment, perioperative pain physiology and treatment as well as further development of the concept ”accelerated operation course”.Mechanisms and prevention of chronic pain after surgeryOptimisation of the surgical nursingDepartment of Psychology, Play Therapy and Social Counselling
Psychosocial aspects of disease and treatmentPsychosocial reactions in mothers and fathers on pregnancy, birth and maternity leaveFathers’ relations to their babies and infantsTreatment of obese childrenPsychological, social and sexological aspects of rapeSexually abused childrenPsychosocial and neuro-psychological late symptoms in radiotherapy and chemotherapy in childhoodMen’s healthThe Fertility Department
Clinical trials in Assisted Reproductive Technology (ART).
Immunological and genetic causes of recurrent miscarriage
Single emsbryo transfer strategies
Cancer and reproductionLaboratory of Reproductive Biology
Endocrine regulation of growth, maturation and ovulation of the ovarian follicle
Effect of smoking and other environmental chemicals on the differentiation of the reproductive system of the human foetus
Cryopreservation of human ovaries and testes as means of fertility preservation
Derivation of human embryonic stem cells and their differentiation
Regulation of meiosis in human and murine oocytes
Improving ovarian stimulation in women undergoing assisted reproduction.
Molecular genetics and pathophysiology
Inborn errors of metabolism
Cytogenetics of acute leukemia
Ion transport in epithelia and glands of the respiratory tract
Department of Neonatology Perinatal brain damage
Late outcome in individuals born preterm
Intrauterine growth restriction and the programming hypthesis Department of Obstetrics Diabetes and pregnancyResearch in medical educationPregnancy in women with blood-type immunizationHeart diseases in pregnant womenReasons for secondary inertiaHelping pregnant women stop smokingPremature birthsIntrauterine monitoring of foetuses at riskThrombophilia in pregnant womenPerinatal health service research and audit.Obstetric skills trainingOverweight women and pregnancyExercise and pregnancyPsychological factors and acute caesarean sectionCentre of Fetal Medicine and Ultrasound
Screening for Down's syndrome and congenital malformations.
Screening in women pregnant after assisted reproductive technology.
The informed choice and first trimester risk estimate.
The effect of Progesterone on the risk of preterm delivery in twin pregnancies.
Advanced invasive procedures.
Screening for and assessment of intrauterine growth retardation.
3D/4D-UL in the assessment of the development of the fetal face and fetal heart
Department of Paediatrics and Adolescent MedicineIndividualised therapy and late effect studies of children with cancer or rheumatological diseases
Paediatrics in developing country Epilepsy and neuromuscular diseasesCerebral paresisInflammatory markers in rheumatologic diseases and bone-marrow transplantationPrevention and treatment of complications in cystic fibrosis, ciliary dyskinesia, asthma, respiratory syncytial virus and broncho-pulmonal dysplasiaMapping the natural history of childhood leukaemiaDepartment of Kennedy Centre
The research in the Kennedy Center is organized in five main research activities:
Specific diseases and areas under these categories include Tourette syndrome, dopa responsive dystonia, the fragile X syndrome, Menkes syndrome, PKU and related disorders, Down syndrome, Rett syndrome and other mental retardation syndromes. Some of the rare genetic eye diseases we work with are aniridia, congenital cataract, congenital glaucoma, retinitis pigmentosa, optic atrophy, microphthalmia, and albinism.
-------------------------------------------------------- The Neuroscience Centre
Multidisciplinary Pain CentreEpidemiology, non-cancer and cancerChronic non-cancer pain conditionsOpioidsPalliationDepartment of Clinical Neurophysiology
Physiology and pathophysiology in the peripheral neuromuscular system
Regeneration of nervous and muscular tissue
Physiology and pathophysiology of the central nervous system in normal subjects and in connection with multiple sclerosis
Motor control in connection with spasticity
Diagnosis and treatment of severe epilepsies
Biotechnology, particularly concerning signal analysis of muscle and nerve electrical signals
Department of Neuroanaesthesiology
Cerebrovascular function and cerebral metabolismNeuroprotection in critically ill patientsHigh altitude physiologyDepartment of NeurosurgeryThe dynamics of cerebro-spinal fluid and resorption resistanceMolecular biology in connection with aneurysms in InuitsBrain aquaporins in connection with brain oedema and glioblastomaBrain tumours and subarachnoid haemorrhageRadiosurgery in connection with tumours and vascular abnormalitiesFunctional surgery, e.g. Parkinson’s disease or epilepsyOperation methods in connection with herniated diskDepartment of NeurologyThe department of neurology contains the following research units:
Epilepsy Clinic, Memory Disorders Research Unit, Neurobiology Research Unit & Center for Integrated Molecular Brain Imaging (Cimbi), Neuromuscular Research Unit, The Danish Multiple Sclerosis Research Centre, Vascular and General NeurologyEpilepsy ClinicClinical experiments with new anticonvulsantsPharmacokinetics of newer anticonvulsantsEpilepsy surgeryFertility aspects of anticonvulsant treatmentReflex epilepsyLocal functional - anatomic changes in Juvenile Myoclonic Epilepsy (JME)Phenotyping of JME – sub-groups for genetic researchAutomatic signal and image editing of epileptic seizureThe Memory Disorders Research Group & the Danish Dementia Info Center
Clinical and neurogenetic research in Alzheimer's disease and other neurodegenerative disorders, including familial disorders and normal pressure hydrocephalus:
Early diagnosis, drug development and innovation in social intervention
Social and legal aspects
Neurobiology Research Unit & Center for Integrated Molecular Brain Imaging (Cimbi)Studies of the brain’s receptor and pathophysiology with SPECT (single photon emission computer tomography) and PET (positron emission tomography)The brain’s functional structure, studies with PET and fMRI (functional magnetic resonance imaging)Methods for data analysis of PET, MR and SPECT.Brain blood flow regulation and receptor conditionsCelullar and anatomical analysis on receptor regulation and binding
Genetic studies on receptor regulation
Neuromuscular Research UnitTreatment and diagnostics of muscle diseases and neuropathies
Basic physiological studies of myopathies
Mitochondrial biology: Role for aging and disease
Muscle regeneration in muscular dystrophies and treatment models
Phenotype-genotype relations in hereditary muscle diseases
Exercise physiology and treatments for metabolic myopathies
Danish Multiple Sclerosis Research Centre
(Including the Neuroimmunology Laboratory)
Investigator driven studies of new treatments of MS
Neuroimaging of MS: PET and MRI
Cognitive dysfunction in MS patients
Genetic risk factors of MS
Immune activation and treatment effect on leukocyte subgroups
Biomarkers of treatment response
Pathology of MS: demyelination and remyelination in progressive MS
Vascular and general neurology
Secondary stroke prevention
Department of Spinal Cord Injury
Evaluation of spasticitiy in individuals with spinal cord lesions
Pain and osteoporosis in individuals with spinal cord lesions
Development of neurorehabilitation techniques guided by investigations of the neuroplasticity (neuroimaging and electrophysiology)
Urological/microbiological projects related to individuals with spinal cord lesions
Respiratory Centre East
Home Mechanical Ventilation research
Tracheostomi adaptation programs and research
Long-term noninvasive ventilation research
Congenit Central Hypoventilation Syndrome research
State-of-the-art research on the development of novel antimicrobial materials and surface coatings to be used in respiratory medical devices
Part of CRAM international association (Centre for Research on Respiration and Antimicrobial Materials)
----------------------------------------------- The Nordic Cochrane Center
Systematic reviews and meta-analyses.
Methodologic research, particularly related to randomised trials, observational studies and meta-analyses.
Placebo, including the effect of nonspecific interventions.
Copenhagen Trial Unit (CTU) and Cochrane Hepato-Biliary Group (CHBG) Randomised clinical trials in prevention, treatment and care. Systematic reviews and meta-analyses.Methods and technology related to randomised clinical trials and meta-analyses. Cochrane Hepato-Biliary Group:Systematic reviews of interventions and registration of specialist literature within hepato-biliary diseases.-------------------------------------------------------- UCSF - University Hospitals Centre for Nursing and Care ResearchDevelopment of concepts and theoretical background within improved health, caring and nursingNear-patient clinical intervention research (cancer and intensive care area)Cancer rehabilitationResearch in networking among patient groupsEvidence-based nursing in theory and practice-------------------------------------------------------- CEKU - Centre for Clinical Education Competence evaluation of specialistsALS projectSimulation-based training in airway endoscopySimulation-based training in cardio-vascular study/treatmentInter-professional teachingCompetence assessment in education of junior doctors and internsEffect of systematic training in the medical conversationMandatory course in pedagogical practise for introductory doctors
Medical experts from Copenhagen University Hospital Rigshospitalet have in collaboration with international colleagues developed European guidelines on how to handle abnormal uterine bleeding during and after menopause aiming inter alia to reduce the number of unnecessary uterine Dilatation and Curettage (D&C) procedures.
One thing is to have state-of-the-art scanners; another thing is to decode the scan images. Rigshospitalet was one of the first hospitals in Europe to acquire an ultra-fast CT scanner. The hospital is now teaching physicians from all over the world to read scans of the heart.
Measurable effects of prioritised and focussed health and safety initiatives only come after implementation; transforming words into action in daily routines. This is what makes a winner and it is on this basis that Rigshospitalet received the European Good Practice Award in April 2013.